Providing adaptive QoS to layered video over wireless local area networks through real-time retry limit adaptation

Robust streaming of video over 802.11 wireless LANs (WLANs) poses many challenges, including coping with packets losses caused by network buffer overflow or link erasures. In this paper, we propose a novel error protection method that can provide adaptive quality-of-service (QoS) to layered coded video by utilizing priority queueing at the network layer and retry-limit adaptation at the link layer. The design of our method is motivated by the observation that the retry limit settings of the MAC layer can be optimized in such a way that the overall packet losses that are caused by either link erasure or buffer overflow are minimized. We developed a real-time retry limit adaptation algorithm to trace the optimal retry limit for both the single-queue (or single-layer) and multiqueue (or multilayer) cases. The video layers are unequally protected over the wireless link by the MAC with different retry limits. In our proposed transmission framework, these retry limits are dynamically adapted depending on the wireless channel conditions and traffic characteristics. Furthermore, the proposed priority queueing discipline is enhanced with packet filtering and purging functionalities that can significantly save bandwidth by discarding obsolete or un-decodable packets from the buffer. Simulations show that the proposed cross-layer protection mechanism can significantly improve the received video quality.     

Combination of variable frequency train stimulation and K/sup +/ channel blockade to augment skeletal muscle force

Several innovative approaches are being used to optimize the input-output relationship of muscle, including nonlinear stimulation paradigms and altering muscle membrane ion channel conductances. We tested the hypothesis that the combination of the K+ channel blocker, 3,4-diaminopyridine (DAP), and variable frequency train (VFT) stimulation improves muscle force to a greater extent than either modality alone. Studies were done in vitro on rat diaphragm muscle and contractions were quantified with respect to peak force, mean force, and force area. DAP increased all three force parameters by >50% during conventional 10-20-Hz stimulation, whereas VFT stimulation improved contractile performance for peak force only. When combined, DAP and VFT stimulation augmented peak force to a significantly greater extent than either modality alone. However, this came at a cost of a moderate decline in force area relative to DAP alone, although mean force was preserved. These force increases were generally well-maintained over the course of short-term repetitive stimulation. Thus, VFT stimulation and K+ channel blockade interact in a complex manner to modulate skeletal muscle force. The utility of the combined intervention for functional electrical stimulation may be greatest for mechanical tasks requiring high force levels early during the contraction.     

Differential automatic zero-adjusting amplifier

A method is described for building a low-voltage-drift differential dc amplifier featuring automatic zero adjustment, a high input impedance, and a bandwidth of 10 kHz. This is achieved by an asymmetric two-step process between the input signal and ground. Bandwidth can be extended by the use of a second amplifier during the ground-sampling time. The amplifier can be made with standard electronic components. A major advantage of this method is that an existing amplifier can easily be converted into a low-voltage-drift amplifier by adding the essential elements of the described automatic zero-adjusting amplifier to its input stage. To illustrate the method a practical example is constructed featuring a drift of 0.2 microV/ degrees C.     

Epilepsy or paroxysmal kinesigenic choreoathetosis?

A 71-year-old man was admitted due to brain infarction. An abnormal floating mass was found in the right atrium by echocardiography. The mass was assumed to be a thrombus. The patient was failed to be in danger of pulmonary embolism, so it was decided to remove surgically. The thrombus was removed under cardiopulmonary bypass including the atrial wall where it was attached, because it was difficult to rule out the possibility of cardiac tumor macroscopically. The tumor showed pathological findings of thrombus. Postoperative course was uneventful.     

Multilead ECG analysis

This paper describes the results of our recent research in computer-assisted ECG/VCG interpretation. It comprises new developments which were initiated by the advent of relatively inexpensive microcomputers. Our previous systems performed an off-line analysis of ECGs. Currently, there is a trend to move computer power near to the patient and to provide on-line analysis of ECGs. Besides the advantage of the direct availability of the ECG interpretation, quality control will reduce the number of uninterpretable ECGs and hence the number of repeated recordings. This paper describes the requirements that were established for a system for on-line ECG analysis. The system is based on our modular approach, just like our off-line system, Modular ECG ANalysis System (MEANS). Changes in the methods and software had to be made mainly because of the simultaneity of all ECG leads and the concurrency of the processing tasks. Other modifications and extensions of the algorithms necessary to meet the requirements of on-line ECG interpretation especially those related to processing speed, are discussed, and evaluation results are presented.     

Genetic Elements Orchestrating Lactobacillus crispatus Glycogen Metabolism in the Vagina

Glycogen in the female lower reproductive tract is a major carbon source for colonization and acidification by common vaginal Lactobacillus species, such as Lactobacillus crispatus. Previously, we identified the amylopullulanase encoding gene pulA of Lactobacillus crispatus to correlate with the ability to autonomously utilize glycogen for growth. Here, we further characterize genetic variation and differential regulation of pulA affecting the presence of its gene product on the outer surface layer. We show that alpha-glucan degrading activity dissipates when Lactobacillus crispatus is grown on glucose, maltose and maltotriose, in agreement with carbon catabolite repression elements flanking the pulA gene. Proteome analysis of the S-layer confirmed that the amylopullulanase protein is highly abundant in an S-layer enriched fraction, but not in a strain with a defective amylopullulanase variant or in an amylopullulanase-sufficient strain grown on glucose. In addition, we provide evidence that Lactobacillus crispatus pulA mutants are relevant in vivo, as they are commonly observed in metagenome datasets of human vaginal microbial communities. Analysis of the largest publicly available dataset of 1507 human vaginal metagenomes indicates that among the 270 samples that contain a Lactobacillus crispatus pulA gene, 62 samples (23%) had a defective variant of this gene. Taken together, these results demonstrate that both environmental, as well as genetic factors explain the variation of Lactobacillus crispatus alpha-glucosidases in the vaginal environment.     

Exciton storage by Mn(2+) in colloidal Mn(2+)-doped CdSe quantum dots

Colloidal Mn (2+)-doped CdSe quantum dots showing long excitonic photoluminescence decay times of up to tau exc = 15 mus at temperatures over 100 K are described. These decay times exceed those of undoped CdSe quantum dots by approximately 10 (3) and are shown to arise from the creation of excitons by back energy transfer from excited Mn (2+) dopant ions. A kinetic model describing thermal equilibrium between Mn (2+ 4)T 1 and CdSe excitonic excited states reproduces the experimental observations and reveals that, for some quantum dots, excitons can emit with near unity probability despite being approximately 100 meV above the Mn (2+ 4)T 1 state. The effect of Mn (2+) doping on CdSe quantum dot luminescence at high temperatures is thus completely opposite from that at low temperatures described previously.     

Could SGLT2 Inhibitors Improve Exercise Intolerance in Chronic Heart Failure?

Despite the constant improvement of therapeutical options, heart failure (HF) remains associated with high mortality and morbidity. While new developments in guideline-recommended therapies can prolong survival and postpone HF hospitalizations, impaired exercise capacity remains one of the most debilitating symptoms of HF. Exercise intolerance in HF is multifactorial in origin, as the underlying cardiovascular pathology and reactive changes in skeletal muscle composition and metabolism both contribute. Recently, sodium-related glucose transporter 2 (SGLT2) inhibitors were found to improve cardiovascular outcomes significantly. Whilst much effort has been devoted to untangling the mechanisms responsible for these cardiovascular benefits of SGLT2 inhibitors, little is known about the effect of SGLT2 inhibitors on exercise performance in HF. This review provides an overview of the pathophysiological mechanisms that are responsible for exercise intolerance in HF, elaborates on the potential SGLT2-inhibitor-mediated effects on these phenomena, and provides an up-to-date overview of existing studies on the effect of SGLT2 inhibitors on clinical outcome parameters that are relevant to the assessment of exercise capacity. Finally, current gaps in the evidence and potential future perspectives on the effects of SGLT2 inhibitors on exercise intolerance in chronic HF are discussed.