Engineering a pharmacologically superior form of leptin for the treatment of obesity

Leptin plays a central role in the homeostasis of body weight through its regulatory effects on appetite and energy expenditure, yet in trials as a therapeutic agent for the treatment of obesity in humans it has been disappointing. The poor clinical efficacy of leptin results from its short circulating half-life, low potency and poor solubility, necessitating large and frequent doses to obtain even modest clinical benefit. Engineered Fc-leptin immunofusins, consisting of the Fc fragment of an immunoglobulin gamma chain followed by leptin, exhibit improved pharmacological properties with very consistent and potent biological activities. Furthermore, in extending the circulating half-life of the protein in vivo from a few minutes for leptin to many hours for Fc-leptin, these proteins have the potential to reduce drastically the dosage and frequency of administration required to obtain clinical benefit. The results of this study show that the engineered leptin immunofusins described here have significantly enhanced pharmacological properties in comparison with the recombinant leptin that was used in clinical trials. As such, they could represent an important step towards a therapeutically superior form of leptin if the disappointing performance of leptin in early clinical trials was due to its poor pharmacological properties rather than any conceptual weakness in the strategy of using leptin for the treatment of obesity and its related disorders.     

甲醇/正己烷的渗透汽化分离的研究 Ⅰ.渗透汽化膜的研制

本文研制了从甲醇／正己烷体系中分离甲醇的渗透汽化复合膜ＣＡ／ＰＡＮ（ＰＥＳ）、ＰＶＡ／ＰＡＮ（ＰＥＳ）。实验证明膜对该体系有较高的选择分离性和良好的渗透性，当进料甲醇浓度为３％时，渗透通量Ｊ≈０．６００ｋｇ／ｈ·ｍ２，分离因子α→∝。本文还考察了不同操作条件对膜分离性能的影响及膜的稳定性和均匀性。     

Morphologic study of electrochemically formed lead dioxide

Various electrochemical methods with different conditions were used to prepare lead dioxide (PbO₂). The observation revealed that the morphology of deposited PbO₂ could be controlled by simply changing deposition parameters. Under the condition of oxygen evolution, which dominates the electrode process, uniformly distributed high porous structured PbO₂ was formed. The results indicated that large current density or high potential polarization should be one of the most important and necessary factors for forming high surface area PbO₂ deposit. Only β-PbO₂ was identified by X-ray diffraction measurement for the deposit prepared by present methods and solution. One potential application of this method is to prepare nanoscaled PbO₂ parallel lines.     

QH-2型扁环填料的流体力学和传质性能研究

在内径60 0填料塔中 ,用空气 富氧水系统对3 8和5 0QH 2型扁环填料的流体力学和传质性能进行了研究 ,得出计算其压降、液泛气速和传质单元高度的关联式。并与3 8鲍尔环、5 0鲍尔环和3 8环矩鞍填料进行了比较 ,结果表明 ,QH 2型扁环具有优良的流体力学和传质特性。     

毛细管动态挤出下聚合物熔体非线性流变行为的研究

采用毛细管动态流变仪,选用PELD、PP、PS和PA等典型物料,研究了毛细管动态挤出下各聚合物熔体的非线性流变行为。结果表明,不同物料的流变行为对振动力场的响应特性有较大差异,只有在一定的振幅和频率下振动力场才能有效降低熔体的黏度。实验首次发现,PP、PS和PA存在窄的振动参数区域,在此区域内,熔体的动态表观黏度值大于相应的稳态值,出现“加振变黏”现象。这一新的发现表明,并非“只要引入振动就一定有利于聚合物材料的成型加工”,必须考虑不同分子结构的聚合物材料对振动的不同响应规律。     

木塑复合材料的研究开发进展

近年来，木塑材料以其优越的性能越来越得到广泛的应用，本文对木塑材料在国内外研究现状，木塑材料的种类和加工助剂、加工条件、机械等方面进行了简单的介绍。     

计算机网络联结的一种新参考模型

斐波纳契余图CFn是n维立方体(n≥2)顶点坐标中具有两个或以上“1”相邻的顶点所导出的子图,它具有哈密顿通路,其半径为n-2,当n≥4时直径为n,CF3n 1是哈密顿图(n≥1)。     

Gd3（1-x）Al5O12：RE3X分立材料芯片制备及发光性能研究

将组合材料芯片技术中四元组合法应用于新型发光材料Gd3（1-x）Al5O12：RE3X的RE激活剂和敏化剂种类优选.由Gd3Al5O12基体材料芯片获得如下的研究结果：1）在紫外激发下（254 nm）Gd3（1-x）Al5O3：Eu3x材料具有红色荧光性能;2）Pr（n（Pr）：n（Eu）＜1：10）、Ce（n（Ce）：n（Eu）＜1：10）共掺杂时会降低发光强度.光谱分析表明：Pr、Ce能级嵌入,使得激活剂和敏化剂发生共振能量传递,是Gd3Al5O12：Eu（简称为GAG：Eu）发光效率降低的主要原因.筛选结果得到柠檬酸盐硝酸盐溶胶凝胶法制备粉体筛选实验结果验证.实验结果表明组合法在发光材料开发上具有高效性.     

Virsual Basic 6.0在三档或三档以上回转窑设计中的应用

众所周知，三档或三档以上水泥回转窑属于静不定结构，采用手算相当麻烦，少则一周多则一个月，而且精确度难以保证，为此我院80年代利用Basic语言在DOS操作系统下开发出了电算程序(以下简称老程序)，计算效率比较高。但随着计算机技术的小断发展，老程序的计算范围和操作系统无法满足水泥回转窑设计的要求，目前我们采用流行的Visual Basic 6．0对回转窑计算程序进行了重新编程(以下简称新程序)，以满足回转窑设计要求。     

NBR/Zn(MAA)2/蒙脱土纳米复合材料的研究

研究NBR／基丙烯酸锌[Zn(MAA)2]／蒙脱土纳米复合材料的性能。结果表明，Zn(MAA)2可以通过原位聚合反应在与NBR发生接枝交联的同时，实现对蒙脱土的插层，用该方法制备的NBR／Zn(MAA)2／蒙脱土纳米复合材料的物理性能优异，含有有机改性蒙脱土HMMT和USM的复合材料性能更为突出，且具有一定的透明性。