ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes

Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesterol esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. Minor changes in subsequent structure were found to have a significant effect in optimization of the biological activity of this series of compounds.     

Frequent clones of p53-mutated keratinocytes in normal human skin

The multiple genetic hit model of cancer predicts that normal individuals should have stable populations of cancer-prone, but noncancerous, mutant cells awaiting further genetic hits. We report that whole-mount preparations of human skin contain clonal patches of p53-mutated keratinocytes, arising from the dermal-epidermal junction and from hair follicles. These clones, 60-3000 cells in size, are present at frequencies exceeding 40 cells per cm2 and together involve as much as 4% of the epidermis. In sun-exposed skin, clones are both more frequent and larger than in sun-shielded skin. We conclude that, in addition to being a tumorigenic mutagen, sunlight acts as a tumor promoter by favoring the clonal expansion of p53-mutated cells. These combined actions of sunlight result in normal individuals carrying a substantial burden of keratinocytes predisposed to cancer.     

More investigations of leakage and nonleakage conductor-backedcoplanar waveguide

Through rigorous full-wave analysis, the effective dielectric constant, normalized attenuation constant, characteristic impedance, and radiation pattern of two types of conductor-backed coplanar waveguides are obtained. The analytic results show that the leakage effect is not only controlled by the thickness and dielectric constant of the substrate but also by the slot width. The leakage power transforms to a radiation space wave and a surface wave, the transverse electric field diagrams in the substrate and the far-zone radiation pattern verify the leakage phenomenon. The first structure has the maximum radiation intensity in the endfire direction, while the second one which has more leaky waves radiates into the air, is better served as a radiating device. For both structures under the nonleakage condition, the characteristic impedance is sensitive to the change of the strip width but not the slot width. Using these properties, the nonleaky and leaky circuits can exist on the same circuit board by choosing appropriate circuit dimensions     

微量Ag对CP276合金性能和组织的影响

研究添加不同含量的Ａｇ对ＣＰ２７６合金的拉伸性能和时效组织的影响。对拉伸强度、延伸率测试及透射电镜观察表明：０．１１ｗｔ％加入可促进Ｔ１相析出，使合金强度值升高；０．３５ｗｔ％Ａｇ的加入可在时效前期生成富Ａｇ、Ｍｇ的稳定的ＧＰ区，从而降低合金中Ｃｕ的固溶度，阻碍Ｔ１相析出，时效后期，ＧＰ区分解，生成大量Ｔ１相，使合金强度值显著升高。     

美国西雅图先锋广场历史保护区的形成

考察美国西雅图先锋广场历史保护区形成的过程,可以看出城市历史文化遗存的保护是经济与历史文化合力作用的结果,公众参与在城市历史文化保护工作中发挥着重要的作用。我国城市经济高速发展,保护与发展的矛盾冲突还没得到很好解决,先锋广场的例子对我们具有一定的参考价值。     

Enhancement of power system data debugging using GSA-based data-mining technique

In this paper, a gap-statistic-algorithm (GSA)-based data-mining technique is applied to enhance the data debugging in power system operations. In the proposed approach, the GSA technique is embedded into a neural network frame in anticipation of improving the detection capability of bad data. Thanks to the clustering capability exhibited by GSA in which the number of clusters can be optimally determined, the proposed approach becomes highly effective to localize the group of abnormal data. This proposed approach has been tested through the data collected from different scenarios made on an IEEE 30-bus system and 118-bus systems. Test results reveal the feasibility of the method for the data diagnosis applications.     

Characterization of ultrashort optical pulses with third-harmonic-generation based triple autocorrelation

We present a method to obtain complete information of femtosecond pulses. By measuring triple-optical autocorrelation directly with third-harmonic generation, without spectral information, a temporal pulse shape can be obtained by analytical calculation without direction-of-time ambiguity. Combining the resulting optical pulse shape with its corresponding optical spectrum, the exact phase and color variations in time can all be recovered with a Gerchberg-Saxton algorithm through an iterative calculation with an O(n) complexity.     

科技期刊编辑专业化和学者化是保证期刊学术质量的关键

一般科技期刊刊载的论文内容都具有很强的专业性,这就要求科技期刊编辑必须具有丰富的专业知识和较高的学术水平才能胜任编辑工作.从编辑过程的选题组稿、论文初审、选择审稿专家和编辑加工四个方面对此进行了阐述,指出了提高科技期刊编辑的相关专业知识和学术水平的措施.     

An orthogonal basis for the hyperbolic hybrid polynomial space

Motivated by the wide usage of the Tchebyshev basis and Legendre basis in the algebra polynomial space, we construct an orthogonal basis with the properties of the H-Bézier basis in the hyperbolic hybrid polynomial space, which is similar to the Legendre basis and holds remarkable properties. Moreover, we derive the transformation matrices that map the H-Bézier basis and the orthogonal basis forms into each other. An example for approximating the degree reduction of the H- Bézier curves is sketched to illustrate the utility of the orthogonal basis.     

炼钢工序的变化与挑战——柳钢"十五"期间炼钢的进步与工艺特点

简述了炼钢工序在柳钢"十五"期间工艺和装备的变化及其特点.对工序变化进行了初步分析.