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61.
G Zwadlo-Klarwasser M Vogts W Hamann K Belke J Baron W Schmutzler 《Canadian Metallurgical Quarterly》1998,47(11):434-439
OBJECTIVE AND DESIGN: This study was designed to establish the sites of formation and storage of histamine and histidine decarboxylase (HDC) in human monocytes and two of their subsets. MATERIALS AND METHODS: The experiments were carried out using monocytes from buffy coats of healthy blood donors. Histamine was quantitated by RIA, HDC activity by the formation of histamine. RESULTS: The monocyte subtype RM3/1 contained significantly more histamine than the subset 27E10 (0.041+/-0.025 vs. 0.005+/-0.004 pg/cell, p < 0.05) and also more HDC activity and HDC mRNA. After fractionation of monocyte homogenates in a discontinuous Percoll gradient or by differential centrifugation more than 80% of both, HDC activity and histamine, were recovered from the cytosolic fractions. About 50% of this histamine was found to be bound to proteins. CONCLUSIONS: In monocytes histamine and HDC are colocalized in the cytoplasm indicating a subcellular distribution different from mast cells or basophils. The data also show that histamine is synthesized by the monocytes themselves. 相似文献
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63.
Serum samples from 47 men with current condylomas, 32 men with a history of condylomas and from 205 men with no history of genital wart disease, who were attending sexually transmitted disease (STD) clinics at two different hospitals in Stockholm, were analyzed for the presence of immunoglobulin G (IgG) and A (IgA) antibodies to capsids of human papillomavirus types 6 and 11. IgG to HPV type 6 was found among 35% of patients with a history of condylomas compared to 10% of controls (p = 0.0003), but only among 27% of patients with current condylomas. Antibodies to HPV 6 and to HPV 11 showed a very limited correlation, suggesting that the antibodies are HPV-type restricted. The results strengthen conclusions from a previous serological study indicating that IgG antibodies against HPV 6 develop late during condylomatous disease and mostly reflect previous exposure to the virus. 相似文献
64.
Intensified insulin therapy of type I diabetics can now be rendered more patient-friendly through the use of rapid-action insulin. Thus, for example, the rapid absorption of the monomeric lispro insulin (Humalog) out of the subcutaneous fatty tissue obviates the need to observe a delay between injection and meal, and the changed kinetics of action reduce the danger of postprandial episodes of hypoglycemia. In addition to practice-relevant hints on the use of these new short-acting insulins in intensified insulin therapy, this short article reviews the current state of the development of a new long-acting insulin that is shortly to be tested in an international multi-center phase III study. 相似文献
65.
S. Williams M. Hecht M. Petersen R. Strelitz M. Maltrud J. Ahrens M. Hlawitschka B. Hamann 《Computer Graphics Forum》2011,30(3):991-1000
We present analysis and visualization of flow data from a high‐resolution simulation of the dynamical behavior of the global ocean. Of particular scientific interest are coherent vortical features called mesoscale eddies. We first extract high‐vorticity features using a metric from the oceanography community called the Okubo‐Weiss parameter. We then use a new circularity criterion to differentiate eddies from other non‐eddy features like meanders in strong background currents. From these data, we generate visualizations showing the three‐dimensional structure and distribution of ocean eddies. Additionally, the characteristics of each eddy are recorded to form an eddy census that can be used to investigate correlations among variables such as eddy thickness, depth, and location. From these analyses, we gain insight into the role eddies play in large‐scale ocean circulation. 相似文献
66.
Hamann C Woltmann R Hong IP Hauptmann N Karan S Berndt R 《The Review of scientific instruments》2011,82(3):033903
An electrospray apparatus for deposition of organic molecules on surfaces in ultrahigh vacuum is presented. The kinetic energy at the impact and mass to charge ratio of deposited ions can be controlled by an electrostatic quadrupole deflector and an in-line quadrupole mass spectrometer. With an ion funnel in the first two vacuum stages a high ion transmission is achieved. Experiments on porphyrin cations and deoxyribonucleic acid deposited on a Au(111) surface demonstrate the capabilities of the instrument. 相似文献
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68.
Apostolos Papanikolaou Rainer Hamann Byung Suk Lee Christian Mains Odd Olufsen Dracos Vassalos George Zaraphonitis 《Accident; analysis and prevention》2013
The new probabilistic damaged stability regulations for dry cargo and passenger ships (SOLAS 2009), which entered into force on January 1, 2009, represent a major step forward in achieving an improved safety standard through the rationalisation and harmonization of damaged stability requirements. There are, however, serious concerns regarding the adopted formulation for the calculation of the survival probability of passenger ships, particularly for ROPAX and large cruise vessels. The present paper outlines the objectives, the methodology of work and main results of the EU-funded FP7 project GOALDS (Goal Based Damaged Stability, 2009–2012), which aims to address the above shortcomings by state-of-the-art scientific methods and by formulating a rational, goal-based regulatory framework, properly accounting for the damage stability properties of passenger ships and the risk of people onboard. 相似文献
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70.
Yunhui Gong Kun Fu Shaomao Xu Jiaqi Dai Tanner R. Hamann Lei Zhang Gregory T. Hitz Zhezhen Fu Zhaohui Ma Dennis W. McOwen Xiaogang Han Liangbing Hu Eric D. Wachsman 《Materials Today》2018,21(6):594-601
Designing solid-state lithium metal batteries requires fast lithium-ion conductors, good electrochemical stability, and scalable processing approaches to device integration. In this work, we demonstrate a unique design for a flexible lithium-ion conducting ceramic textile with the above features for use in solid-state batteries. The ceramic textile was based on the garnet-type conductor Li7La3Zr2O12 and exhibited a range of desirable chemical and structural properties, including: lithium-ion conducting cubic structure, low density, multi-scale porosity, high surface area/volume ratio, and good flexibility. The solid garnet textile enabled reinforcement of a solid polymer electrolyte to achieve high lithium-ion conductivity and stable long-term Li cycling over 500?h without failure. The textile also provided an electrolyte framework when designing a 3D electrode to realize ultrahigh cathode loading (10.8?g/cm2 sulfur) for high-performance Li-metal batteries. 相似文献