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31.
32.
Identification of Comprehensive Metabotypes Associated with Cardiometabolic Diseases in the Population‐Based KORA Study 下载免费PDF全文
33.
Lohner K Schnäbele K Daniel H Oesterle D Rechkemmer G Göttlicher M Wenzel U 《Molecular nutrition & food research》2007,51(3):293-300
Flavonoids are secondary plant metabolites included in our diet but are also provided in a growing number of supplements. They are suggested to interact with intestinal transport systems including phospho-glycoprotein (P-gp) which mediates the efflux of a variety of xenobiotics back into the gut lumen. In human intestinal Caco-2 cells, we tested the effects of 14 different flavonoids on P-gp expression in vitro. Protein expression levels were quantified by Western blotting, flow cytometry, and real-time PCR. Except apigenin, all flavonoids at concentrations of 10 microM increased P-gp expression in Western blotting experiments when cells were exposed to the compounds over 4 wk. Flavone was one of the most effective P-gp inducers in Caco-2 cells and its effects were, therefore, also assessed for changes in P-gp in vivo in the gastrointestinal tract of C57BL/6 mice. P-gp expression was significantly increased by flavone (400 mg/kg body weight x day over 4 wk) in the small intestine but not in the colon which displayed intrinsically the highest expression level. In conclusion, the increase in P-gp expression caused by flavonoids in intestinal epithelial cells in vitro and also in vivo may serve as an adaptation and defense mechanism limiting the entry of lipophilic xenobiotics into the organism. 相似文献
34.
Arthur H. Schmidt Michael Petri Monika Fuchs Hannelore Endres Susanne Kortmann 《Advanced Synthesis \u0026amp; Catalysis》1994,336(3):211-217
Oxocarbons and Related Compounds. 20. By Thiophenols Mediated Conversion of Semisquaric Hydrazides to Squaric-1,2-Diamides In the presence of thiophenols semisquaric hydrazides ( 4 ) are converted into squaric-1,2-diamides ( 6 ) upon heating in alcoholic solution. Proof is given that thiosquaric-S-ester-amides ( 8 ) are intermediates in this process. 相似文献
35.
The catalytic properties of Pt, Rh and Co supported on mesoporous molecular sieves with MCM-41-type structure consisting of
SiO2 and Al2O3 were studied for the reduction of NO with propene. Pt supported on siliceous MCM-41 was the most active catalyst, however,
significant quantities of undesirable N2O were formed during the reaction. Pt supported on mesoporous Al2O3 and Rh supported on both mesoporous oxides showed a lower activity, but an improved selectivity towards N2 formation. Co supported on MCM-41-type materials had only a low level of activity for the reduction of NO with propene. For
Pt supported on MCM-41-type materials only a minor decrease in the activity was observed when water vapor was added into the
reactant gas mixture, while on Rh- and Co-containing catalysts the activity strongly decreased.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
36.
The Synthesis of α-Pyridones from Ketones and Urea By acid-catalyzed reaction of ketones with urea, the condensed α-pyridones 2, 8, 9, 10, 12a–d are formed. 相似文献
37.
Christian Bischoff Hannelore Herma Edith Schrder 《Advanced Synthesis \u0026amp; Catalysis》1977,319(2):230-234
The Synthesis of Pyrimidine-2,4-diones from Ketones and Urea By reaction of urea with 2-alkylcyclohexanones or with 2-alkylcyclohexanonecarboxamides 8-alkyl-5,6,7,8-tetrahydrobenzo-[1,2-d]pyrimidine(1H,3H)-2,4-diones ( 5a–i ) are formed. Cyclohexanone or cyclohexanone-2-carboxamide with urea form 5,6,7,8-tetrahydro-benzo-[1,2-d]pyrimidine(1H,3H)-2,4-dione ( 3 ). Menthone, 2,6-dimethylcyclohexanone, 3,5-diphenylcyclohexanone, cyclooctanone and cyclododecanone with urea yield pyrimidinediones 9, 10, 11, 12a and 12b . 相似文献
38.
Abera Belay Gulelat Desse Haki Marc Birringer Hannelore Borck Young-Chul Lee Chang-Won Cho 《International Journal of Food Properties》2017,20(11):2855-2866
Three hundred twenty honey samples were collected from Ethiopia, and categorized into nine monofloral honeys using melissopalynology. Theses monofloral honeys were investigated for their sugar profile, physicochemical properties, and quality of honeys. Sugars (fructose, glucose, sucrose, maltose, turanose, and isomaltose) were identified using high-performance liquid chromatography and physicochemical properties (moisture, water activity, pH, acidity, ash, minerals, conductivity, colour) using the Harmonized Method of the International Honey Commission. Moisture and water activity showed a strong regression coefficient (r2 = 0.92). Moisture content alone did not sufficiently describe the quality of honey during storage and processing. 相似文献
39.
Milne CJ Van der Veen RM Pham VT Lima FA Rittmann-Frank H Reinhard M van Mourik F Karlsson S Penfold TJ Chergui M 《Chimia》2011,65(5):303-307
We review our recent studies of excited state structures and dynamics of chemical and biological systems with pico- and femtosecond X-ray absorption spectroscopy in the liquid phase. 相似文献
40.
Medium‐chain dicarboxylic acylcarnitines as markers of n‐3 PUFA‐induced peroxisomal oxidation of fatty acids 下载免费PDF全文