Cyclosporine A inhibits lymphocyte migration into ovine peripheral nerve allografts

Lymphocyte migration into nerve allografts was measured to estimate the cyclosporine A (CsA) dose required to suppress rejection. Twelve outbred sheep received daily subcutaneous CsA at 0, 5, 10, or 15 mg/kg/day for 2 weeks prior to implantation of multiple heterotopic subcutaneous nerve grafts. Lymphocyte migration was determined after 7 days by an intravenous pulse of autologous 111indium-labeled lymphocytes and subsequent quantitation of gamma radioactivity in nerve tissue (CPM/g, mean +/- SEM). Measurement by radioimmunoassay revealed a dose-dependent increase in blood cyclosporine levels. Lymphocyte migration into autografts (404+/-44) was significantly less than migration into allografts (16,554+/-2,049), in control animals (P < 0.01). A dose-dependent inhibition of lymphocyte migration into nerve allografts was observed with counts of 7,662+/-1,692, 4,083+/-1,112, and 1,561+/-232 in sheep receiving 5, 10, or 15 mg/kg/day of CsA, respectively. Daily CsA administration produced effective blood levels and immunosuppression sufficient to inhibit lymphocyte migration into nerve allografts.     

Diabetes mellitus in pregnancy

Physiologic changes that occur during pregnancy are diabetogenic. If diabetes does not exist before pregnancy, it may become evident, and if diabetes pre-exists, it becomes aggravated. The changing insulin requirements and propensity for ketoacidosis require weekly visits and careful urine testing on a daily basis by the mother. In addition, microvascular complications of diabetes must be carefully monitored. Delivery is planned progressively early in the pregnancy according to diabetic class. Hospitalization is necessary one week before anticipated delivery. Urinary estriol tests, OCT, amniocentesis, and ultrasound are all helpful in managing the pregnancy. Delivery of the fetus and placenta results in a profound fall in the insulin requirement. The neonate should be carefully observed during the first few days of life because of the increased frequency of complications.     

Personalisation and Web Communities

Even in Web communities where the primary aim is to share information and networks with members of similar interests, personalised information management services are highly desirable. Applications that tailor services to the individual improve personal productivity and increase the value of the underlying eCommunity beyond a social or networking instrument. Thus, software systems designed to support Web communities should satisfy dual and somewhat conflicting objectives of maximising member interaction and information sharing, while providing personalised services and protecting individual privacy. One collaborative effort described in this paper has, we believe, achieved those objectives, via a balance between, on the one hand, promoting aggregation and sharing of information resources, and, on the other hand, reserving profile management and privacy settings for the individual user. The successful integration of expertise in personal software agents, resource management middleware, and eCommunity platforms has culminated in a commercial product, through the joint efforts of BTexact Technologies, Fujitsu Laboratories, and Teamware Group Ltd.     

The role of antisociality in the psychopathy construct: Comment on Skeem and Cooke (2010).

J. Skeem and D. J. Cooke (2010) asserted that Hare and Neumann consider criminality to be an essential component of the psychopathy construct. The assertion, presented in the guise of a debate on the nature of psychopathy, is neither accurate nor consistent with the clinical and empirical literature on psychopathy to which Hare and Neumann have contributed. Broadly defined antisociality, not criminality per se, is considered to be part of the psychopathy construct. Skeem and Cooke also expressed concerns that the popularity of the Psychopathy Checklist—Revised (R. D. Hare, 2003) inhibits the development and use of other instruments, that it has become the construct it measures, that it deviates from its clinical roots, and that it conflates criminality with personality. These and related issues are addressed, and it is suggested that the arguments proffered by Skeem and Cooke are not convincing, nor do they provide clear directions for theory and research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Silicon nano-particles in SiO2 sol–gel film for nano-crystal memory device applications

A novel 2-bit nano-silicon based non-volatile memory is proposed to double memory density. The thin film structure exhibits two conduction states (ON and OFF) at different voltages and has a cost-effective structure. The structure utilizes the good electrical properties of fluorinated SiO₂ thin films, together with the bi-stable properties conferred by the nano-silicon particles therein embedded. A polymeric layer of 8-hydroxyquinoline aluminum salt (Alq3) further deposited on the top of the nano-particle layer through chemical evaporation and a silver paste contact determines the final structure. The positive 0–15 V scan reveals two discontinuities with an ON/OFF ratio of 10⁴–10⁵ (2–4 V) and OFF/ON of 10³ (12.5–13.0 V). The reverse scan displays again two distinct thresholds, range of 10.5–11.0 V (ON/OFF ratio 10⁻³), respectively, 0.5 V (OFF/ON ratio 10⁻⁵–10⁻⁴).     

Intergenerational transmission of aggression in romantic relationships: The moderating role of attachment security.

This prospective study used longitudinal, multi-reporter data to examine the influence of parents’ marital relationship functioning on subsequent adolescent romantic relationships. Consistent with Bryant and Conger’s (2002) model for the Development of Early Adult Romantic Relationships (DEARR), we found that interactional styles, more specifically paternal aggression and satisfaction, exhibited in parents’ marital relationship when their adolescents were age 13 were predictive of qualities of the adolescent’s romantic relationships 5 years later. Continuities were domain specific: paternal satisfaction predicted adolescent satisfaction and paternal aggression predicted adolescent aggression. Attachment security moderated the link between paternal aggression and subsequent adolescent aggression, with continuities between negative conflictual styles across relationships reduced for secure adolescents. Results are interpreted as suggesting that attachment may help attenuated the transmission of destructive conflict strategies across generations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Understanding Paul Moxnes (1999).

P. Moxnes's (see record 1999-13879-001) model of deep roles is contrasted with alternative taxonomies of roles, including ones developed by F. Redl (1942), R. F. Bales (e.g., T. Parsons, R. F. Bales, & E. A. Shils, 1953), G. Polti (1977), and A. P. Hare (see record 1994-98134-000 and 1995-05269-001). Moxnes's analysis has implications for the development of roles in groups over time, but questions can be raised about the emphasis on individual roles (rather than their combination) and the automaticity of evaluation. As a new perspective on roles, Moxnes's work provides an opportunity to reassess past work to see how much variance has been left unaccounted for by studies of roles. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Neomycin,but Not Neamine,Blocks Angiogenic Factor Induced Nitric Oxide Release through Inhibition of Akt Phosphorylation

Angiogenesis, the growth of new blood vessels, is a critical factor of carcinogenesis. Neomycin and neamine, two drugs blocking the nuclear translocation of angiogenin (ANG), have been proven to inhibit tumour growth in vivo. However, the high toxicity of neomycin prevents its therapeutic use, thus indicating that the less toxic neamine may be a better candidate. Endothelial cells were cultured on a biocompatible multiple microelectrode array (MMA). The release of NO evoked by ANG or vascular endothelial growth factor (VEGF) was detected electrochemically. The effects of neomycin and neamine on ANG- and VEGF-induced NO releases have been investigated. Neomycin totally blocks NO release for concentrations down to the pM range, probably through the inhibition of the Akt kinase phosphorylation, as revealed by confocal microscopy. On the other hand, both ANG- and VEGF-induced NO releases were not significantly hindered by the presence of high concentrations of neamine. The inhibition of the Akt pathway and NO release are expected to lead to a severe decrease in tissue growth and repair, thus indicating a possible cause for the toxicity of neomycin. Furthermore, the data presented here show that ANG- and VEGF-induced NO releases are not dependent on the nuclear translocation of angiogenin, as these events were not abolished by the presence of neamine.