Ipriflavone: an important bone-building isoflavone

Ipriflavone, an isoflavone synthesized from the soy isoflavone daidzein, holds great promise in the prevention and treatment of osteoporosis and other metabolic bone diseases. It has been widely studied in humans and found effective for inhibiting bone resorption and enhancing bone formation, the net result being an increase in bone density and a decrease in fracture rates in osteoporotic women. While ipriflavone appears to enhance estrogen's effect, it does not possess intrinsic estrogenic activity, making it an attractive adjunct or alternative to conventional hormone replacement therapy. Preliminary studies have also found ipriflavone effective in preventing bone loss associated with chronic steroid use, immobility, ovariectomy, renal osteodystrophy, and gonadotrophin hormone-releasing hormone agonists. In addition, it holds promise for the treatment of other metabolic diseases affecting the bones, including Paget's disease of the bone, hyperparathyroidism, and tinnitus caused by otosclerosis.     

Southwest Oil Field Makes Breakthroughs in Natural Gas Exploration

Three structures in Northeast Sichuan 　　A series of breakthroughs have recently been made in natural gas exploration in the northeastern part of Sichuan basin. Dukouhe Gas Field, Luojiazhai gas-beating structure and Tieshan slope gasbearing structure are proven rich in natural gas resources. The main gas reservoir of those structuresFeixianguan oolitic shoal - is likely to become another largescale gas reservoir in Sichuan basin after Carboniferous.……     

Perceived interactivity leading to e-loyalty: Development of a model for cognitive–affective user responses

Novel applications of website interactivity are important to attract and retain online users. In this empirical study five designs for interactivity are examined using different web-poll interfaces. The goal of the investigation is to examine perceived interactivity in a model which includes most commonly tested cognitive elements such as efficiency and effectiveness, but augments this model with the inclusion of a cognitive–affective element for trust, and an affective element of enjoyment. More specifically, a model is created to validate the relationship of perceived interactivity (comprised of user control, user connectedness, and responsiveness of the web-poll application) to efficiency, effectiveness, trust and enjoyment, of the website. In turn, efficiency, effectiveness, trust, and enjoyment are tested for their influence on user behavioral intentions for e-loyalty. All relationships in the model are supported. In addition, exploratory evaluation of qualitative comments is conducted to investigate additional insights between the five web-poll treatments in this investigation. The research confirms the complexity of a model in which cognitive, cognitive–affective and affective elements are present, and advances knowledge on the consequences of perceived interactivity. In additional to theoretical advancements, the research has merit for web designers and online marketers regarding how to enhance interactive online web applications.     

压力容器用封头制造质量控制和专业化生产发展方向

中国法规首次对压力容器等特种设备用封头实施制造资格许可和强制的监督检验制度。本文根据法规标准的规定,对压力容器封头制造质量控制和专业化生产发展方向的要求作一系统的综述,以提高压力容器产品的整体质量,确保特种设备安全万无一失。     

减少离散大系统两级镇定控制的保守性

The aim of this paper is to propose a new algorithm for multilevel stabilization of large scale systems. In two-level stabilization method, a set of local stabilizers for the individual subsystems in a completely decentralized environment is designed. The solution of the control problem involves designing of a global controller on a higher hierarchical level that provides corrective signals to account for interconnections effect. The principle feature of this paper is to reduce conservativeness in global controller design. Here, the key point is to reduce the effect of interactions instead of neutralizing them. In fact, unlike prior methods, our idea does not ignore the possible beneficial aspects of the interactions and does not try to neutralize them.     

Double-Wiebe function: An approach for single-zone HCCI engine modeling

Single-zone Wiebe-function HCCI combustion models tend to over-predict the peak cylinder pressure. The over-prediction arises because it is not possible for the standard Wiebe function to fully match both the slower combustion (i.e. the large spread of autoignition times) that occurs in the cooler boundary regions adjacent to the walls and the faster combustion (small spread of autoignition times) in the hot core. The slower combustion by the wall is commonly modeled with a multi-zone approach. The aim of this work was to improve the ability of a single-zone model to predict cylinder pressure without introducing a separate wall zone. This was accomplished by using, within a single zone, a double-Wiebe function combustion model in which most of the fuel burns as usual but a minor fraction (typically 10–20%) burns at a reduced rate. In the present article, cylinder pressure traces predicted by using both standard and double-Wiebe functions are compared to experimental pressure traces obtained from a Ricardo Hydra HCCI engine. The best agreement with the experiments was obtained by using double-Wiebe function approach.     

Some aspects of twist drill design

A mathematical approach to the flute disposal capacity based on the diameter of the circle which could be inscribed in the flute space is presented. It is important to know what order of drill rigidity is required for good performance when drilling various work materials. The main features of the cross-section profile which could affect the stiffness of a twist drill are the cross-sectional area and the second moment of area. The relationship between the various drill parameters and these features is one aspect to be investigated in this paper. Empirical equations based on the results obtained from this investigation are presented.     

Using global positioning system for bus priority in London: traffic signals close to bus stops

London's bus network is one of the largest and most comprehensive urban transport systems in the world. The contribution of buses is recognised by implementing a series of initiatives including bus priority at traffic signals. London has a long history of the implementation of bus priority at traffic signals. It has kept pace with the development of new technologies by updating its bus priority system. Now, London is moving towards a bus management system based on global positioning system (GPS), which will also be used to provide bus priority at traffic signals. The authors describe theoretical work carried out by TRG on behalf of Transport for London Bus Priority Team to tackle the challenge posed by locational error associated with GPS where a traffic signal is close to a bus stop     

Effect of rilmenidine on the cadiovascular responses to stress in the conscious rabbit

The acetoacetyl-CoA reductase and the polyhydroxyalkanoate (PHA) synthase from Ralstonia eutropha (formerly Alcaligenes eutrophus) were expressed in Escherichia coli, Klebsiella aerogenes, and PHA-negative mutants of R. eutropha and Pseudomonas putida. While expression in E. coli strains resulted in the accumulation of poly(3-hydroxybutyrate) [PHB], strains of R. eutropha, P. putida and K. aerogenes accumulated poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [poly(3HB-co-3HHx)] when even chain fatty acids were provided as carbon source, and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [poly(3HB-co-3HV)] when odd chain fatty acids were provided as carbon source. This suggests that fatty acid degradation can be directly accessed employing only the acetoacetyl-CoA reductase and the PHA synthase. This is also the first proof that the PHA synthase from R. eutropha can incorporate 3-hydroxyhexanoate (3HHx) into PHA and has, therefore, a broader substrate specificity than previously described.     

Thrombospondin-1 expression in human myometrium before and during pregnancy, before and during labor, and in human myometrial cells in culture

The activation of latent transforming growth factor beta (L-TGFbeta) is essential for the action of TGFbeta, which, in turn, is involved in the regulation of expression of some progesterone-responsive genes. One mechanism by which TGFbeta is activated involves thrombospondin (TSP), a protein that binds extracellular proteins. Immunoreactive TSP (irTSP) protein and TSP-1 mRNA in myometrial tissues of ovulatory and pregnant women were localized by immunohistochemistry and in situ hybridization. IrTSP and TSP-1 mRNA were randomly distributed in myometrial smooth muscle cells of some, but not all, tissues of pregnant women at term before labor; but in some areas of most of these tissues, irTSP was intense and commonly localized extracellularly. Intense irTSP and TSP-1 mRNA in myocytes were more common in myometrium during labor. In myometrium from ovulatory women (n = 26), irTSP was localized primarily in vascular smooth muscle cells and was detected occasionally in scattered myocytes. Little TSP-1 mRNA was demonstrable by in situ hybridization in vessels or myocytes of myometrial tissue from ovulatory women (n = 7). By Northern analysis of total RNA, TSP-1 mRNA was detected in myometrial tissue of pregnant women and in human myometrial smooth muscle cells in culture. The levels of TSP-1 mRNA in myometrial tissues of pregnant women during labor (n = 18) were greater than those in myometrium at > 37 wk gestation before labor began (n = 25, p < 0.001). The ratios of TSP-1 to glyceraldehyde 3-phosphate dehydrogenase mRNAs in 3 myometrial tissues during oxytocin-induced labor were not statistically different from those in myometrium during spontaneous labor but were greater than those in myometrium before labor (p < 0.05). The level of TSP-1 mRNA in confluent human myometrial cells in culture was relatively high, was increased by treatment with fetal bovine serum, and was decreased by treatment with platelet-derived growth factor or activators of adenylyl cyclase or protein kinase C. Myometrial cells in culture constitute a useful model for studying the regulation of TSP-1 gene expression in human myometrium.