Industrial Knowledge Bases as Drivers of Open Innovation?

The article presents an analysis of a large-scale survey with the aim of understanding differences in the open, interactive and distributed nature of external innovation relations amongst firms belonging to different industrial knowledge bases. The thesis is that the source of critical innovation relevant knowledge differs between industrial knowledge bases, making the character and the need of openness contingent on these specificities. Accordingly, we anticipate that we will observe systematic variations in how industries access and combine innovation-related external knowledge. In our analyses we attempt to address a gap in the literature by examining how industrial knowledge bases affect the recombination of knowledge by analysing the different extents, forms (formal and informal) and geography of inbound open innovation. The article illustrates that features and structures of inbound open innovation align, to a large extent, with the industries' knowledge bases and that there is a interplay between an industry's knowledge base, the internal organisation of innovation processes and the channels and geography of inbound open innovation.     

Deconvolution Combined with Digital Colocalization Analysis to Study the Spatial Distribution of Tight and Adherens Junction Proteins

The relative spatial distribution of proteins was investigated with immunofluorescent methods by confocal laser scanning microscopy and digital image restoration. For confocal data sets recorded with a voxel dimension of 50 × 50 × 150 nm noise and blur can be decreased and the resolution in the z-axis increased by applying the maximum likelihood estimation algorithm of the Huygens software. This approach was successfully applied to the study of tight and adherens junctions in relation to the actin cytoskeleton in Madin Darby Canine Kidney cells. Colocalization analysis was done for pairs of probes using a histogram-based method. F-actin, occludin, zonula occludens 1, and E-cadherin were included in the study. Double-labeled preparations were used. The combination of deconvolution with the colocalization of confocal data sets offers a powerful tool to investigate the spatial arrangement of proteins.     

A field survey of metal binding to metallothionein and other cytosolic ligands in liver of eels using an on-line isotope dilution method in combination with size exclusion (SE) high pressure liquid chromatography (HPLC) coupled to Inductively Coupled Plasma time-of-flight Mass Spectrometry (ICP-TOFMS)

The effect of metal exposure on the accumulation and cytosolic speciation of metals in livers of wild populations of European eel with special emphasis on metallothioneins (MT) was studied. Four sampling sites in Flanders showing different degrees of heavy metal contamination were selected for this purpose. An on-line isotope dilution method in combination with size exclusion (SE) high pressure liquid chromatography (HPLC) coupled to Inductively Coupled Plasma time-of-flight Mass Spectrometry (ICP-TOFMS) was used to study the cytosolic speciation of the metals. The distribution of the metals Cd, Cu, Ni, Pb and Zn among cytosolic fractions displayed strong differences. The cytosolic concentration of Cd, Ni and Pb increased proportionally with the total liver levels. However, the cytosolic concentrations of Cu and Zn only increased above a certain liver tissue threshold level. Cd, Cu and Zn, but not Pb and Ni, were largely associated with the MT pool in correspondence with the environmental exposure and liver tissue concentrations. Most of the Pb and Ni and a considerable fraction of Cu and Zn, but not Cd, were associated to High Molecular Weight (HMW) fractions. The relative importance of the Cu and Zn in the HMW fraction decreased with increasing contamination levels while the MT pool became progressively more important. The close relationship between the cytosolic metal load and the total MT levels or the metals bound on the MT pool indicates that the metals, rather than other stress factors, are the major factor determining MT induction.     

Emissions of DEHP‐free PVC flooring

Degrading 2‐ethylhexyl‐containing PVC floorings (eg DEHP‐PVC floorings) and adhesives emit 2‐ethylhexanol (2‐EH) in the indoor air. The danger of flooring degradation comes from exposing occupants to harmful phthalates plasticisers (eg DEHP), but not from 2‐EH as such. Since the EU banned the use of phthalates in sensitive applications, the market is shifting to use DEHP‐free and alternative types of plasticisers in PVC products. However, data on emissions from DEHP‐free PVC floorings are scarce. This study aimed at assessing the surface and bulk emissions of two DEHP‐free PVC floorings over three years. The floorings were glued on the screed layer of concrete casts at 75%, 85%, and 95% RH. The volatile organic compounds (VOCs) were actively sampled using FLEC (surface emissions) and micro‐chamber/thermal extractor (µ‐CTE, bulk emissions) onto Tenax TA adsorbents and analyzed with TD‐GC‐MS. 2‐EH, C9‐alcohols, and total volatile organic compound (TVOC) emissions are reported. Emissions at 75% and 85% RH were similar. As expected, the highest emissions occurred at 95% RH. 2‐EH emissions originated from the adhesive. Because the two DEHP‐free floorings tested emitted C9‐alcohols at all tested RH, it makes the detection of flooring degradation harder, particularly if the adhesive used does not emit 2‐EH.     

Comparing in situ particle monitoring to microscopic counts of plankton in a drinking water reservoir

In a one-year study, the multispecies assemblages of phytoplankton (picoplankton to microplankton) within a drinking water reservoir were counted, determined and evaluated in their size fractions using microscope enumeration (MC). The manual counts were compared with the size evaluation obtained by a light obscuring particle counter (PC) in order to evaluate its use for the monitoring practice of a drinking water reservoir. With this multispecies comparison we present a novel approach for the evaluation of automated counting systems.The picoplankton clearly remained uncounted by the PC even though its lower size limits imply an adequate match. The highest and most consistent count numbers of plankton (nano- and microplankton) and particles were obtained during the spring mass development. However, from the middle of the year onwards, the measured particle concentration surpassed the counted plankton abundances by two- to threefold indicating the rise of seston within the water column. This fraction would be missed if counted solely by MC. Further, the PC consistently undersized the biological counts, but not the minerogenic fraction represented by the manganese oxidising bacteria. Consequently, the rise and decline of Metallogenium bacteria was reliably monitored with the PC.The PC provides additional size information compared to other bulk optical sensors (turbidity, chlorophyll-a). The correlation of particles with probe measurement always exceeded the plankton coefficient, but all combinations of plankton, particle and probe measurement revealed significant linear regressions. However, the redundancy of the chlorophyll-a probes was also shown in order to explain plankton abundances.Our results indicate that background knowledge of the monitored system and cautious interpretation of data is required to allocate and understand automated particle counts. Therefore, only in combination with MC, the PC enables phytoplankton or minerogenic particle counts under frequent real-time monitoring conditions. As such it may serve as a helpful tool for example in critical situations in the management of drinking water reservoirs.     

The relationship of peritraumatic dissociation and posttraumatic stress: Findings in female Vietnam theater veterans.

This study examined the relationship of dissociation at the time of trauma, as assessed by the Peritraumatic Dissociation Experiences Questionnaire, Rater Version (PDEQ-RV; C. R. Marmar, D. S. Weiss, & T. J. Metzler, in press), and posttraumatic stress symptoms in a group of 77 female Vietnam theater veterans. PDEQ-RV ratings were found to be associated strongly with posttraumatic stress symptomatology, as measured by the Impact of Event Scale (M. J. Horowitz, N. Wilner, & W. Alvarez; see record 1980-26834-001), and also positively associated with level of stress exposure and general dissociative tendencies, measured by the Dissociative Experiences Scale. The PDEQ-RV was unassociated with general psychiatric symptomatology, as assessed by the clinical scales of the Minnesota Multiphasic Personality Inventory-2 (J. N. Butcher, W. G. Dahlstrom, J. R. Graham, A. Tellegen, & B. Kaemmer, 1989). The PDEQ-RV was predictive of posttraumatic stress symptoms beyond the contributions of level of stress exposure and general dissociative tendencies. The findings provide further support for the reliability and validity of the PDEQ-RV as a measure of peritraumatic dissociation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Social constraints, intrusive thoughts, and depressive symptoms among bereaved mothers.

The study examined how social constraints on discussion of a traumatic experience can interfere with cognitive processing of and recovery from loss. Bereaved mothers were interviewed at 3 weeks (Tl ), 3 months (T2), and 18 months (T3) after their infants' death. Intrusive thoughts at Tl, conceptualized as a marker of cognitive processing, were negatively associated with talking about infant's death at T2 and T3 among socially constrained mothers. The reverse associations were found among unconstrained mothers. Controlling for initial level of distress, there was a positive relation between T1 intrusive thoughts and depressive symptoms over time among socially constrained mothers. However, higher levels of T1 intrusive thoughts were associated with a decrease in T3 depressive symptoms among mothers with unconstrained social relationships. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Acculturation, sexual risk taking, and HIV health promotion among Latinas.

Latinas are nearly 3 times more likely to acquire AIDS than other women in the United States. It is critical to understand this vulnerability and to identify predictors of risk. Structural equation models were used to test predictors, mediators (including components of the health belief model), and sex-related outcomes and behavior. Interview data were collected from a random, cross-sectional community sample of 227 sexually active Latinas (M age?=?32 years). Acculturation was associated with higher HIV-related risks within primary relationships. Older Latinas were less likely than younger Latinas to make behavior changes or use barrier methods of contraception to prevent HIV, and they had higher rates of unintended pregnancies. Marriage was related to greater relationship risk and less behavior change. Theoretical models must account for ethnicity, race, and culture to understand better unwanted sexual outcomes for Latinas, including HIV risks. Strategies are needed that specifically address these issues in HIV prevention and counseling programs. (PsycINFO Database Record (c) 2010 APA, all rights reserved)