Zusammenhang zwischen der im instrumentierten Kerbschlagbiegeversuch ermittelten Bruchverformungsarbeit und der dynamischen Rißzähigkeit hochfester Stähle in Abhängigkeit von Temperatur und Kerbschärfe

An den Stählen St 52-3 und 35 NiCrMoV 12 5 wurden im instrumentierten Kerbschlagbiegeversuch bei einer Schlaggeschwindigkeit von 5 m/s die Bruchverformungsarbeit und die dynamische Rißzähigkeit bei unterschiedlicher Kerbschärfe und Prüftemperatur bestimmt. Es wurden die Einflüsse aufgezeigt, die bei der Bestimmung der wahren Bruchverformungsarbeit E_d gegenüber dem beim Kerbschlagbiegeversuch aufgenommenen Arbeitsverbrauch a_K berücksichtigt werden müssen. Die Versuchsergebnisse wurden verglichen und diskutiert, wobei auch die Gültigkeit einer Modellvorstellung von A. S. Tetelman zur Bestimmung der Rißzähigkeit an endlich gekerbten Proben überprüft wird.     

源于共同的机械、电气和自动化设计的薄板坯连铸连轧工艺开发

西马克德马格公司在冶金工业方面是一个领先的工业工厂解决方案提供商.统一设计的机械、电气和自动化方案使我们的用户无论是在产品质量、产量、生产的灵活性、工艺的稳定性以及易维护性方面,拥有了生产具有高性能的高级材料的技术.在薄板坯连铸连轧领域,这样的共同开发的例子如下①CSP薄板坯连铸.结晶器液面控制,液压结晶器振动,用于楔形和速度优化的自动导航,带有LCR3(液芯压下)的液压扇形段调整,动态二冷水和结晶器监视系统;②CSP轧机.用于带材板形、连续凸度、平直度控制和自由轧制,采用了特定的磨辊以及相配套的串辊策略的CVC+技术;③用于实现厚度小于1mm带钢高效热轧的"薄规格技术包",包括采用"张力差活套"或"张力计活套"以及快速液压机构配合相应的自动化模块,如自动调平控制,以活套测量为基础的平直度控制,尾部监控或以楔形测量为基础的调平预设定.不仅是机械和电气的共同设计,还有共同的项目执行都将使工厂的运营者受益.例如,对于现代化改造项目和新安装的工厂,通过在交货之前在实验室内的联合测试,项目的投产时间得以优化."工厂回路测试(PILT)"将仿真或甚至机械部件本身与真实的自动化系统(1级,2级和人机界面HMI)结合在一起.通过这样的共同解决方案,西马克德马格公司在电气和自动化领域已发展成"从电机轴一直到生产计划系统"的成套供货商和系统集成商,其目标就是致力于与其用户的长期伙伴关系,并与用户分享其所拥有的工艺经验.     

Design and characterization of the balloon-borne Michelson Interferometer for Passive Atmospheric Sounding (MIPAS-B2)

MIPAS-B2 is a balloon-borne limb-emission sounder for atmospheric research. The heart of the instrument is a Fourier spectrometer that covers the mid-infrared spectral range (4-14 microns) and operates at cryogenic temperatures. Essential for this application is the sophisticated line-of-sight stabilization system, which is based on an inertial navigation system and is supplemented with an additional star reference system. The major scientific benefit of the instrument is the simultaneous detection of complete trace gas families in the stratosphere without restrictions concerning the time of day and viewing directions. The specifications, the design considerations, the actual realization of the instrument, and the results of characterization measurements that have been performed are described.     

Epidemiological investigation on chronic copper toxicity to children exposed via the public drinking water supply

Copper in drinking water has been associated with Non-Indian Childhood Cirrhosis (NICC), a form of early childhood liver cirrhosis. This epidemiological study examines the exposition of infants to increased copper concentrations through drinking water from public water supplies in Berlin, Germany, and if this dietary copper intake can cause liver damage in early childhood. In total, water samples from 2944 households with infants were tested for copper. Mean copper concentrations in the two different types of collected composite samples were 0.44 and 0.56 mg/l, respectively. Families having a copper concentration at or above 0.8 mg/l in one or both of the composite samples (29.9% of all sampled households) and a defined minimum ingestion of tap water of their infant were recommended to undergo a paediatric examination. Nearly every of the 541 recommended infants were examined by a local paediatrician and of these 183 received a blood serum analysis, too. None of the infants had clear signs of a liver disease although a few serum parameters lay outside the accompanying reference range and abdominal ultrasound imaging gave slightly unusual results in five cases. Additionally, no signs of a negative health effect could be found in the statistical analysis of the serum parameters GOT, GPT, GGT, total bilirubin, serum copper, or ceruloplasmin in relation to estimated daily and total copper intakes of the infants from tap water. No dose relation of serum parameters and estimated copper intakes could be established. From the results of the study, no confirmed indication of a liver malfunction in infants whose food had been prepared using tap water with an elevated copper concentration could be found and, therefore, no indication of a hazard due to copper pipes connected to public water supplies could be detected.     

Biological tissue characterization by magnetic induction spectroscopy (MIS): requirements and limitations

Magnetic induction spectroscopy (MIS) aims at the contactless measurement of the passive electrical properties (PEP) sigma, epsilon, and mu of biological tissues via magnetic fields at multiple frequencies. Whereas previous publications focus on either the conductive or the magnetic aspect of inductive measurements, this article provides a synthesis of both concepts by discussing two different applications with the same measurement system: 1) monitoring of brain edema and 2) the estimation of hepatic iron stores in certain pathologies. We derived the equations to estimate the sensitivity of MIS as a function of the PEP of biological objects. The system requirements and possible systematic errors are analyzed for a MIS-channel using a planar gradiometer (PGRAD) as detector. We studied 4 important error sources: 1) moving conductors near the PGRAD; 2) thermal drifts of the PGRAD-parameters; 3) lateral displacements of the PGRAD; and 4) phase drifts in the receiver. All errors were compared with the desirable resolution. All errors affect the detected imaginary part (mainly related to sigma) of the measured complex field much less than the real part (mainly related to epsilon and mu). Hence, the presented technique renders possible the resolution of (patho-) physiological changes of the electrical conductivity when applying highly resolving hardware and elaborate signal processing. Changes of the magnetic permeability and permittivity in biological tissues are more complicated to deal with and may require chopping techniques, e.g., periodic movement of the object.     

Prion diseases: from molecular biology to intervention strategies

Prion diseases are fatal neurodegenerative infectious disorders for which no therapeutic or prophylactic regimens exist. Understanding the molecular process of conformational conversion of the cellular prion protein (PrP(c)) into its pathological isoform (PrP(Sc)) will be necessary to devise effective antiprion strategies. In recent years, new findings in the cell biology of PrP(c), in the molecular pathogenesis of PrP(Sc), and in the cellular quality control mechanisms involved in these scenarios have accumulated. A function of the prion protein in signalling, the possible impact of the proteasome, and aggresomes as intracellular waste deposits have been described. Here, important pathogenetic similarities with the more frequent neurodegenerative disorders are evident. The need for therapeutic, postexposure, and prophylactic possibilities was drastically illustrated by the emergence of variant Creutzfeldt-Jakob disease (vCJD), a new human prion disease caused by bovine spongiform encephalopathy (BSE) derived prions. Although prion infectivity in humans is usually restricted to the central nervous system, in vCJD patients prions are present in the lympho-reticular system, posing a theoretical risk of accidental human-to-human transmission. A variety of chemical antiprion substances have been reported in in vitro and cell culture based assays or in animal studies. Occasionally, they have also made their way into the first human trials. In addition, various promising interference strategies have been devised in transgenic models, although they are usually hard to transfer into nontransgenic in vivo situations. New findings in the fields of peripheral prion pathogenesis and immune system involvement fuelled the search for antiprion strategies formerly considered to be entirely impossible. This opened the door towards classical immunological interference techniques. Remarkably, passive and even active vaccination approaches now seem to be realistic goals.     

Genetic evaluation of Holstein sires and maternal grandsires in the United States for perinatal survival

Stillbirth, defined as a calf that dies just prior to, during, or within 48 h of parturition, represents a reoccurring concern among breeders of dairy cattle in the United States. About 11% of parturitions of primiparous Holstein cows result in the death of a calf; 5.7% in multiparous cows. Genetic evaluations can be reported as perinatal survival to 48 h to emphasize the positive information about the trait. The purpose of this research was to: 1) estimate genetic parameters by restricted maximum likelihood for perinatal survival rates; 2) characterize the genetic evaluation of sires for the perinatal survival of their progeny and maternal grandsires for the perinatal survival of their daughters progeny; and 3) estimate genetic trends from 1984 to 1994. Data (n = 666,339) were from the National Association of Animal Breeders calving ease database. Over 600 new young sires were available each year. The binomial response variable, 1 = alive, 0 = stillborn within 48 h of parturition was analyzed by using a sire-maternal grandsire linear mixed model. The model included fixed effects for sex of calf, dystocia, and season of birth, and gestation length as a covariate; correlated random effects of sire and maternal grandsire; and uncorrelated random effects of herd-years. Parturitions of primiparous and multiparous cows were analyzed separately. In primiparous cows, heritability estimates were 1.1 and 2.2% for sire of the calf and maternal grandsire, respectively. The genetic correlation between sire and maternal grandsire predicted transmitting ability (PTA) for perinatal survival, was 0.31; simple product moment correlations among sire-MGS PTA were 0.43 and 0.46 for primiparous and multiparous cows, respectively. The PTA for sire of the calf ranged from -2.9 (lower survival) to 2.8% (higher survival). Mean PTA from 1984 to 1994 was quite variable from year to year. Evidence showed a slightly negative, but nonsignificant, genetic trend in perinatal survival (-0.04% per year for sires and -0.02% per year for maternal grandsires). Estimates of genetic parameters and genetic trends for data from multiparous cows are also reported. Correlations among PTA for perinatal survival, milk yield, and calving ease are given.     

Variability, covariation, and invariance with respect to coordinate systems in motor control: Reply to Smeets and Louw (2007).

In their comment on the tolerance-noise covariation (TNC) method for decomposing variability by H. Müller and D. Sternad (2003, 2004b), J. B. J. Smeets and S. Louw (see record 2007-01135-017) show that covariation (C), as defined within the TNC method, is not invariant with respect to coordinate transformations and contend that it is, therefore, meaningless. Although the observation is correct, their interpretation is misleading in the following ways: (a) They equate covariation C with the known statistical quantity covariance and noise (N) with standard deviations. The two quantities C and N are conceptually different statistical measures. (b) Dependency on the reference frame is not only a feature of C but of all 3 components. However, such dependency is ubiquitous in motor control. (c) As the frame of reference in biological systems is poorly understood, the TNC method may afford evaluation of different coordinates for control. (PsycINFO Database Record (c) 2010 APA, all rights reserved)