Anticancer Activity of Reconstituted Ribonuclease S-Decorated Artificial Viral Capsid

Ribonuclease S (RNase S) is an enzyme that exhibits anticancer activity by degrading RNAs within cancer cells; however, the cellular uptake efficiency is low due to its small molecular size. Here we generated RNase S-decorated artificial viral capsids with a size of 70–170 nm by self-assembly of the β-annulus-S-peptide followed by reconstitution with S-protein at neutral pH. The RNase S-decorated artificial viral capsids are efficiently taken up by HepG2 cells and exhibit higher RNA degradation activity in cells compared with RNase S alone. Cell viability assays revealed that RNase S-decorated capsids have high anticancer activity comparable to that of standard anticancer drugs.     

End effects of Halbach field magnet-type linear motor

A linear motor that uses a finite length Halbach array as its magnetic field causes a thrust force ripple owing to end effects. In this paper, the theoretical and numerical analysis methods of the Halbach array are investigated. The results of the electromagnetic field analysis are compared to confirm the validity of the theoretical and numerical solutions. Moreover, we focus on the magnetic pole period and coil arrangement of the finite length Halbach field type linear motor to eliminate the influence of the end effects, and report the relationship with the end effects.