GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness

Controlling the outer surface of nanometric metal–organic frameworks (nanoMOFs) and further understanding the in vivo effect of the coated material are crucial for the convenient biomedical applications of MOFs. However, in most studies, the surface modification protocol is often associated with significant toxicity and/or lack of selectivity. As an alternative, how the highly selective and general grafting GraftFast method leads, through a green and simple process, to the successful attachment of multifunctional biopolymers (polyethylene glycol (PEG) and hyaluronic acid) on the external surface of nanoMOFs is reported. In particular, effectively PEGylated iron trimesate MIL‐100(Fe) nanoparticles (NPs) exhibit suitable grafting stability and superior chemical and colloidal stability in different biofluids, while conserving full porosity and allowing the adsorption of bioactive molecules (cosmetic and antitumor agents). Furthermore, the nature of the MOF–PEG interaction is deeply investigated using high‐resolution soft X‐ray spectroscopy. Finally, a cell penetration study using the radio‐labeled antitumor agent gemcitabine monophosphate (³H‐GMP)‐loaded MIL‐100(Fe)@PEG NPs shows reduced macrophage phagocytosis, confirming a significant in vitro PEG furtiveness.     

The stochastic -hub center problem with service-level constraints

Small package delivery companies offer services where packages are guaranteed to be delivered within a given time-frame. With variability in travel time, the configuration on the hub-and-spoke delivery network is vital in ensuring a high probability of meeting the service-level guarantee. We present the stochastic p-hub center problem with chance constraints, which we use to model the service-level guarantees. We discuss analytical results, propose solution heuristics, and present the results from computational experiments.     

Finding the longest common nonsuperstring in linear time

String inclusion and non-inclusion problems have been vigorously studied in such diverse fields as molecular biology, data compression, and computer security. Among the well-known string inclusion or non-inclusion notions, we are interested in the longest common nonsuperstring. Given a set of strings, the longest common nonsuperstring problem is finding the longest string that is not a superstring of any string in the given set. It is known that the longest common nonsuperstring problem is solvable in polynomial time.In this paper, we propose an efficient algorithm for the longest common nonsuperstring problem. The running time of our algorithm is linear with respect to the sum of the lengths of the strings in the given set, using generalized suffix trees.     

On detecting faults for Boolean expressions

Fault based testing aims at detecting hypothesized faults based on specifications or program source. There are some fault based techniques for testing Boolean expressions which are commonly used to model conditions in specifications as well as logical decisions in program source. The MUMCUT strategy has been proposed to generate test cases from Boolean expressions. Moreover, it detects eight common types of hypothesized faults provided that the original expression is in irredundant disjunctive normal form, IDNF. Software practitioners are more likely to write the conditions and logical decisions in general form rather than IDNF. Hence, it is interesting to investigate the fault detecting capability of the MUMCUT strategy with respect to general form Boolean expressions. In this article, we perform empirical studies to investigate the fault detection capability of the MUMCUT strategy with respect to general form Boolean expressions as well as mutated expressions. A mutated expression can be obtained from the original given Boolean expression by making a syntactic change based on a particular type of fault.

Interactive smart battery storage for a PV and wind hybrid energy management control based on conservative power theory

This paper presents interactive smart battery-based storage (BBS) for wind generator (WG) and photovoltaic (PV) systems. The BBS is composed of an asymmetric cascaded H-bridge multilevel inverter (ACMI) with staircase modulation. The structure is parallel to the WG and PV systems, allowing the ACMI to have a reduction in power losses compared to the usual solution for storage connected at the DC-link of the converter for WG or PV systems. Moreover, the BBS is embedded with a decision algorithm running real-time energy costs, plus a battery state-of-charge manager and power quality capabilities, making the described system in this paper very interactive, smart and multifunctional. The paper describes how BBS interacts with the WG and PV and how its performance is improved. Experimental results are presented showing the efficacy of this BBS for renewable energy applications.     

An Experimental Investigation into the Effectiveness of OOA for Specifying Requirements

The application of object oriented concepts (OO) to the requirements phase of information systems (IS) and software development has been adopted by many proponents of IS and software development methodologies. Although many claims have been made about the effectiveness of OO techniques for improving requirements analysis, very few experimental studies have been done to substantiate these claims. This paper addresses this gap in the literature by conducting an experimental study that attempts to validate the effectiveness of object-oriented analysis (OOA) by comparing it to structured analysis (SA) for producing requirements. We argue that the quality of the requirements specification can be measured and that measurement can be used to compare the effectiveness of OOA and SA. We present an overview of the basic models and principles associated with OOA and SA, a discussion of quality in requirements definition, and a detailed discussion of the research methodology used. A review of relevant research is also presented and directions for further research are suggested. Our findings suggest that the OOA methodology does not necessarily produce better requirements statements.     

Discriminant subspace analysis: a Fukunaga-Koontz approach

The Fisher Linear Discriminant (FLD) is commonly used in pattern recognition. It finds a linear subspace that maximally separates class patterns according to the Fisher Criterion. Several methods of computing the FLD have been proposed in the literature, most of which require the calculation of the so-called scatter matrices. In this paper, we bring a fresh perspective to FLD via the Fukunaga-Koontz Transform (FKT). We do this by decomposing the whole data space into four subspaces with different discriminability, as measured by eigenvalue ratios. By connecting the eigenvalue ratio with the generalized eigenvalue, we show where the Fisher Criterion is maximally satisfied. We prove the relationship between FLD and FKT analytically, and propose a unified framework to understanding some existing work. Furthermore, we extend our our theory to Multiple Discriminant Analysis (MDA). This is done by transforming the data into intra- and extra-class spaces, followed by maximizing the Bhattacharyya distance. Based on our FKT analysis, we identify the discriminant subspaces of MDA/FKT, and propose an efficient algorithm, which works even when the scatter matrices are singular, or too large to be formed. Our method is general and may be applied to different pattern recognition problems. We validate our method by experimenting on synthetic and real data.     

Bilattices and Reasoning in Artificial Intelligence: Concepts and Foundations

The past few decades have seen a resurgence ofreasoning techniques in artificial intelligenceinvolving both classical and non-classical logics. Inhis paper, ``Multi-valued Logics: A Uniform Approach toReasoning in Artificial Intelligence', Ginsberg hasshown that through the use of bilattices,several reasoning techniques can be unified under asingle framework. A bilattice is a structure that canbe viewed as a class of truth values that canaccommodate incomplete and inconsistent informationand in certain cases default information. Inbilattice theory, knowledge is ordered along twodimensions: truth/falsity and certainty/uncertainty. By defining the corresponding bilattices as truthspaces, Ginsberg has shown that the same theoremprover can be used to simulate reasoning in firstorder logic, default logic, prioritized default logicand assumption truth maintenance system. Although thisis a significant contribution, Ginsberg's paper waslengthy and involved. This paper summarizes some ofthe essential concepts and foundations of bilatticetheory. Furthermore, it discusses the connections ofbilattice theory and several other existingmulti-valued logics such as the various three-valuedlogics and Belnap's four-valued logic. It is notedthat the set of four truth values in Belnap's logicform a lattice structure that is isomorphic to thesimplest bilattice. Subsequently, Fitting proposed aconflation operation that can be used to selectsub-sets of truth values from this and otherbilattices. This method of selecting sub-sets oftruth values provides a means for identifyingsub-logic in a bilattice.     

Sodium metabisulfite and SO2 release: an under-recognized hazard among shrimp fishermen

Since the introduction of sodium metabisulfite as a food preservative, it has been associated with several idiosyncratic reactions (eg, bronchospasm, oculonasal symptoms, and urticaria/angioedema) in sulfite-sensitive individuals. The pathogenic mechanism of these reactions is not yet understood. We report the case of two crewmen on a shrimp trawler who were found dead in the ship's hold. Their deaths had occurred while they were applying dry sodium metabisulfite, referred to as "shrimp dip" in the shrimping industry. Postmortem examinations showed diffuse pulmonary edema consistent with death secondary to asphyxia. Associated findings were visceral congestion. Although it is possible to measure death from sodium metabisulfite with available records, its potential morbidity cannot be estimated. It is known that sodium metabisulfite can react with acids and water, releasing toxic sulfur dioxide (SO2) gas. In addition, SO2 gas reacts with respiratory tissue forming sulfureous acid, and inducing a pulmonary reaction causing hypoxemia. Furthermore, sodium metabisulfite, compared with sodium bisulfite, has a much greater propensity to release SO2 gas. We conclude that there is a need for improved education regarding the potential side effects of sodium metabisulfite, thus eliminating needless occupational morbidity and mortality.