Hereditary isolated renal magnesium loss maps to chromosome 11q23

Dendritic cells (DC) expanded in the presence of GM-CSF from the bone marrow of C57BL/6 mice process Gram-negative bacteria expressing the model antigen Crl-OVA for peptide presentation on MHC class I molecules. Here we show that presentation of OVA(257-264) processed by DC co-incubated with E. coli expressing Crl-OVA, which contains the Kb-binding OVA(257-264) epitope, occurs by a cytosolic MHC-I presentation pathway. First, we demonstrate the requirement for the transporter associated with antigen processing (TAP) by showing that DC from TAP1-/- mice co-incubated with E. coli expressing Crl-OVA did not result in Kb presentation of OVA(257-264). Second, the proteasome inhibitor MG132 abrogated presentation of OVA(257-264) on Kb when C57BL/6 DC phagocytosed and processed E. coli expressing Crl-OVA. Third, inhibiting protein synthesis using cycloheximide or blocking exocytosis of newly synthesized proteins from the endoplasmic reticulum using brefeldin A abrogated presentation of OVA(257-264) processed from bacteria expressing Crl-OVA by C57BL/6 DC. Finally, peptide regurgitation and loading of OVA(257-264) on neighboring bystander Kb-expressing antigen-presenting cells after BALB/c (H-2d) DC phagocytosed E. coli expressing Crl-OVA could not be detected. Together, these data support a cytosolic MHC-I presentation pathway for OVA(257-264) processed from E. coli expressing Crl-OVA by bone marrow-derived DC.     

在手机屏幕上应用触控笔技术

触控笔的使用将使智能手机变得更加聪明。但目前触控笔在技术上仍然面临诸多挑战,本文将探讨在手机中运用触控笔所面临的各种技术障碍以及成功的触控笔所衍生的应用。     

飞思卡尔:半导体将成为许多解决方案的核心部分

半导体创新是产业的转折点。在以前的PC时代,人们关注的是处理器性能,功耗问题则是通过更大的机箱、添加冷却风扇或使用更大的电池来处理。我们正在进入互联智能时代,嵌入式处理性能需要与功效权衡考虑,系统功能将通过传感器、RF和模拟接口的智能集成来实现。连接性需求始     

一种基于神经网络的多层通孔最小化方法

在多层布线的线段－相交图模型基础上，利用Ｈｏｐｆｉｅｌｄ人工神经网络理论，通过反通孔数目这个优化目标与Ｈｏｐｆｉｅｌ网络能量函烽相联系的方法来解决多层布线通孔最小化问题。算法考虑了许多来自实际的约束。     

基于标准单元库的多级函数分解

本文提出在ASIC综合技术中基于标准单元库的多级逻辑函数分解技术。分解过程利用单元库函数真值矩阵及各分解部分用标准单元实现的难易程度、逻辑级数来评价、引导分解得到的多级逻辑易于用标准单元组合实现。使用的标准单元类型具有较大程度的相似性,有利于基于标准单元布局布线软件进一步减少芯片面积。     

埋空隙PSOI结构的耐压分析

提出了一种埋空隙PSOI (APSOI) RESURF器件结构,此结构利用空隙相对低的介电系数,在器件纵向突破了传统SiO2埋层的耐压关系,提高了击穿电压;硅窗口的存在缓解了有源区的自热效应;不同衬底的场调制作用进一步优化了表面电场分布. 在相同击穿电压条件下,此结构较一般PSOI结构只需1/4厚度的埋层,当漂移区厚度和埋层厚度均为2μm时可获得600V以上的击穿电压.     

为太阳能逆变器选择合适的电容器

选择太阳能逆变器中的能量缓冲器会涉及到元件行为特征的很多细节。因此,明智的做法是在设计阶段的早期就与经验丰富的供应商一起工作,确保所选择的技术能满足所需。太阳能逆变器是一种电源转换装置,主要功能是将蓄电池的直流电逆变成交流电。在其基本原理框图中,DC-DC转换器控制着太阳能电池板的工作点,使之达到最大的功率输出;DC-AC转换器把电能输送到电网,同时执行主电网运营商设立的各种管控规则;能量缓冲器会吸收掉两个转换器之间功率流的差值。选择能量缓冲器的依据如何选择能量缓冲器呢?需要考虑能量缓冲器的大小和时长等因素。能量缓冲器的大小是由需储存     

如何为视频监控应用选择合适的图像传感器

无论在极亮还是极暗条件下,监控摄像机都可清晰记录人的面孔,这有赖于图像传感器的高动态范围。采用高性能图像传感器将能够进一步提升视频监控系统的实用价值,达到理想的使用效果。     

Treatment of axillary bromhidrosis with superficial liposuction

Axillary bromhidrosis or osmidrosis is a distressing problem that causes a serious personal and social handicap, especially in an Asian society. Surgical excision of the subcutaneous tissue, with or without skin excision in the axillary hair-bearing area, has been the treatment of choice for several decades. However, the complications of partial necrosis of wound edges or hematoma, and the possibility of the obvious unsightly scars, are always problems. We report our method of treatment of modified superficial liposuction with subdermal scraping under local anesthesia with tumescent infiltration. By using two tiny stab wounds, these two steps of liposuction can be done in the two-directional crisscross pattern. From August of 1995 to May of 1997, 20 patients (16 women and 4 men) received this surgery for bilateral axillas on an outpatient basis. The follow-up period ranged from 6 months to 27 months, and the mean follow-up period was 14 months. Eighteen patients (90 percent) had excellent to good results. Complication included only one minor wound infection that was cured easily. Two patients experienced transient subdermal fibrotic bands in one side of the axilla, and one patient experienced axillary skin with marked induration and retraction. All of these symptoms disappeared after 1 month or so. This minimal incision operation has the advantages of a high success rate, low complication rate, tiny to invisible scars, no change of hair distribution pattern, minimal postoperative care with a short term of compressive dressing (less than 2 days), and rapid recovery for daily activity and exercise.