A General Structure for Rate-Compatible Concatenated Codes

In this letter, a general concatenated code structure is presented, encompassing both parallel and serially concatenated codes as special cases. The structure provides a unifying framework for the analysis of concatenated codes and offers new degrees of freedom for code design. Performance analysis based on error bounds in the error floor region and suggestions for suitable design criteria are provided, together with a design approach for the waterfall region. The proposed structure allows for constructing very high-rate codes with no penalty in the error floor region and good performance in the waterfall region     

Observer-Based Estimation of Stator-Winding Faults in Delta-Connected Induction Motors: A Linear Matrix Inequality Approach

This paper addresses the subject of interturn short circuit estimation in the stator of a delta-connected induction motor. In this paper, an adaptive observer scheme is proposed. The proposed observer is capable of simultaneously estimating the speed of the motor, the amount turns involved in the short circuit, and an expression of the current in the short circuit. Moreover, the states of the motor are estimated, meaning that the magnetizing currents are made available even though a fault has occurred in the motor. To be able to develop this observer, a model that is particularly suitable for the chosen observer design, is also derived. The efficiency of the proposed observer is demonstrated by tests performed on a test setup with a customized designed induction motor. With this motor it is possible to simulate interturn short-circuit faults.     

Analysis of Likert-scale data: A reinterpretation of Gregoire and Driver.

Most studies that have investigated the use of coarsely grained scales have indicated that the accuracy of statistics calculated on such scales is not compromised as long as the scales have about 5 or more points. Gregoire and Driver (1987), however, found serious perturbances of the Type I and Type II error rates using a 5-point scale. They carried out three computer simulation experiments in which continuous data were transformed to Likert-scale values. Two of the three experiments are shown to be flawed because the authors incorrectly specified the population mean in their simulation. This article corrects the flaw and demonstrates that the Type I and Type II error rates are not seriously compromised by the use of ordinal-scale data. Furthermore, Gregoire and Driver's results are reinterpreted to show that in most cases, the parametric test of location equality shows a power superiority to the nonparametric tests. Only in their most nonnormal simulation does a nonparametric test show a power superiority. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Progressive systemic sclerosis: intrathecal pain management

PURPOSE: To determine if lucanthone crossed the blood-brain barrier in experimental animals; and to determine accelerated tumor regression of human brain metastases treated jointly with lucanthone and whole brain radiation. METHODS AND MATERIALS: The organ distribution of 3H lucanthone in mice and 125I lucanthone in rats was determined to learn if lucanthone crossed the blood-brain barrier. Size determinations were made of patients' brain metastases from magnetic resonance images or by computed tomography before and after treatment with 30 Gy whole brain radiation alone or with lucanthone. RESULTS: The time course of lucanthone's distribution in brain was identical to that in muscle and heart after intraperitoneal or intravenous administration in experimental animals. Lucanthone, therefore, readily crossed the blood-brain barrier in experimental animals. CONCLUSION: Compared with radiation alone, the tumor regression in patients with brain metastases treated with lucanthone and radiation was accelerated, approaching significance using a permutation test at p = 0.0536.     

Structure-based design of inhibitors specific for bacterial thymidylate synthase

Thymidylate synthase is an attractive target for antiproliferative drug design because of its key role in the synthesis of DNA. As such, the enzyme has been widely targeted for anticancer applications. In principle, TS should also be a good target for drugs used to fight infectious disease. In practice, TS is highly conserved across species, and it has proven to be difficult to develop inhibitors that are selective for microbial TS enzymes over the human enzyme. Using the structure of TS from Lactobacillus casei in complex with the nonsubstrate analogue phenolphthalein, inhibitors were designed to take advantage of features of the bacterial enzyme that differ from those of the human enzyme. Upon synthesis and testing, these inhibitors were found to be up to 40-fold selective for the bacterial enzyme over the human enzyme. The crystal structures of two of these inhibitors in complex with TS suggested the design of further compounds. Subsequent synthesis and testing showed that these second-round compounds inhibit the bacterial enzyme at sub-micromolar concentrations, while the human enzyme was not inhibited at detectable levels (selectivities of 100-1000-fold or greater). Although these inhibitors share chemical similarities, X-ray crystal structures reveal that the analogues bind to the enzyme in substantially different orientations. Site-directed mutagenesis experiments suggest that the individual inhibitors may adopt multiple configurations in their complexes with TS.     

Parental reports of coparenting and observed coparenting behavior during the toddler period.

Fifty-two married partners played with their 30-mo-olds in both dyadic (parent–child) and whole family contexts and reported on their own coparenting activities (family integrity-promoting behavior, conflict, disparagement, and reprimand). Coparenting behavior observed in the whole family context was evaluated for antagonism, warmth and cooperation, child–adult centeredness, balance of positive involvement, and management of toddler behavior. Parallel balance and management scores were also formed using dyadic session data. Men's reported family integrity-promoting activities and women's reported conflict and reprimand activities were reliable correlates of family group process in both bivariate and discriminant analyses, with links enduring even after controlling for marital quality. Whole family- and dyad-based estimates of coparenting were altogether unrelated, and reported coparenting was tied only to behavior in family context, not to family measures created from dyad-based data. (PsycINFO Database Record (c) 2010 APA, all rights reserved)