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161.
(1) As a step towards specifying the spatial selectivity characteristics of complex cells with spatially periodic substructures, we have studied single cell responses to narrow slits of variable length moved across the receptive field in the preferred direction. In general, the length-response curves were linear over a considerable and sometimes full range until an optimal slit length was reached. (2) In those cells in which the rate of rise of the slit length-response functions decreased before the optimal length was reached, at least 3 factors contribute to the shape of the curve. First, the receptive field shapes of some complex cells are more ovoid or rounded than rectangular, and the summation of responses from excitatory zones of varying optimal lengths itself results in a nonlinear slit length-response function at long slit lengths. Second, central regions may contribute more to cell response than do more lateral regions along the length dimension. Third, a nonlinearity in the slit length-response curve may occur in the upper range of slit lengths as a saturation effect because discharge rates may reach 600/sec, which appears to be close to a limiting firing rate. (3) Some cells believed to be complex during preliminary receptive field testing showed weak inhibitory regions beyond the region of the optimal slit length. Many of these cells also displayed periodic average response histograms to moving slits. The extent and magnitude of the inhibition were variable from cell to cell. In terms of receptive field properties, these cells and 'regular' complex cells seem part of a continuum.  相似文献   
162.
163.
Technical Physics Letters - In this paper, we describe the main processes occurring during the generation of vacancies in aluminum in the presence of hydrogen by ab initio methods using the SCAN...  相似文献   
164.
Acetylation of histones bound to rat rRNA genes has been studied relative to their organization in chromatin, either as canonical nucleosomes, containing the inactive copies, or as anucleosomal nonrepeating structures, corresponding to the transcribed genes (Conconi, A., Widmer, R. M., Koller, T., and Sogo, J. M. (1989) Cell 57, 753-761). Nuclei from butyrate-treated rat tumor cells were irradiated with a UV laser to cross-link proteins to DNA, and the purified covalent complexes were immunofractionated by an antibody that specifically recognized the acetylated histones. Upon probing with sequences coding for mature rat 28 S RNA, DNA of the antibody-bound complexes was 5-20-fold enriched relative to the total rat DNA. Since the laser cross-links histones to DNA in both active and inactive genes, one cannot distinguish which one of them, or both, are bound to acetylated histones. Alternatively, purified mononucleosomes were immunofractionated, but DNA from the antibody-bound monosomes was not enriched in coding rDNA. Taken together, these results suggest that nucleosome-organized rRNA genes are bound to nonmodified histones and that the acetylated histones are associated with the active, anucleosomal gene copies.  相似文献   
165.
The coexistence of a parasystolic focus, tachycardia dependent right bundle branch aberrancy, and an AV accessory pathway is reported here. This condition was present in a 40-year-old man, which led to an incessant AV reciprocating tachycardia. Further electrophysiological study revealed that the parasystolic focus was located somewhere in the His bundle; endocardial mapping disclosed a right posterior accessory pathway. Radiofrequency current was delivered at the atrial level of the right posterolateral AV groove and successfully ablated the accessory pathway, leading to a dramatic improvement in cardiac function. In conclusion, the recognition of the electrophysiological mechanism of incessant supraventricular tachycardia was of crucial importance for the therapy decision. A definitive intervention using radiofrequency catheter ablation should be considered early and not postponed in patients with tachycardia-induced cardiomyopathy.  相似文献   
166.
    
The Svx proteins are virulence factors of phytopathogenic bacteria of the Pectobacterium genus. The specific functions of these proteins are unknown. Here we show that most of the phytopathogenic species of Pectobacterium, Dickeya, and Xanthomonas genera have genes encoding Svx proteins, as well as some plant-non-associated species of different bacterial genera. As such, the Svx-like proteins of phytopathogenic species form a distinct clade, pointing to the directed evolution of these proteins to provide effective interactions with plants. To get a better insight into the structure and functions of the Svx proteins, we analyzed the Svx of Pectobacterium atrosepticum (Pba)—an extracellular virulence factor secreted into the host plant cell wall (PCW). Using in silico analyses and by obtaining and analyzing the recombinant Pba Svx and its mutant forms, we showed that this protein was a gluzincin metallopeptidase. The 3D structure model of the Pba Svx was built and benchmarked against the experimental overall secondary structure content. Structure-based substrate specificity analysis using molecular docking revealed that the Pba Svx substrate-binding pocket might accept α-glycosylated proteins represented in the PCW by extensins—proteins that strengthen the PCW. Thus, these results elucidate the way in which the Pba Svx may contribute to the Pba virulence.  相似文献   
167.
168.
This paper considers the coordination state of boron and aluminum ions in barium aluminoborate glass with a constant ratio of BaO: B2O3 = 0.5 and a variable ratio of Al2O3: BaO = 0–3. The dependence of the concentrations of boron and aluminum atoms with a variable coordination number on the Al2O3 content was estimated by IR, 11B and 27Al NMR spectroscopy. The nonlinear nature of the obtained dependences was attributed to variations in the aluminum oxide properties. At a content of less than 30 mol % Al2O3 serves primarily as a network former, while an increase in the Al2O3 concentration results in its higher modifying role in the studied glass.  相似文献   
169.
A procedure and findings of investigations of the dynamic characteristics and the wear of fuel elements in the framework of the development of a perspective design of fuel elements without fastening in a lower support grid are presented. At the first phase of the work, natural vibration frequencies and the dynamic rigidity of fuel elements are determined in various design variants of lower spans. Resonance frequencies of spans of fuel elements are revealed by minimums of the dynamic rigidity. At the second phase, investigations of vibrational wear within contact of fuel elements with cells of spacer grids are performed on models of a lower part of a fuel assembly. Four embodiments of the lower part of the fuel assembly are investigated. As a result of the application of high vibrational loads, the wear of fuel element cans and grid cells is observed in more than a half of contact assembles of fuel elements with spacer grids. The most and least wear-resistant designs of the lower part of the fuel assembly are determined by results of tests.  相似文献   
170.
The local structure of glasses and melts in the Na2O-B2O3 system in the composition range 10–30 mol % Na2O is investigated by high-temperature Raman spectroscopy in the temperature range 20–1150°C. The recorded spectra are analyzed by simulating the experimental spectra in the form of a superposition of the set of Gaussian lines. The results of the simulation are used to determine the concentrations of the main structural units of borates as a function of the composition and temperature. The dynamic equilibrium of the interaction between the structural units in melts has the form
$B_{4/2}^ - \rightleftarrows B_{2/2} O^ - $
and shifts toward the right, i.e., toward the formation of BØ2O? metaborate triangles (where Ø is a bridging oxygen atom), with an increase in temperature. The enthalpy of the disproportionation process depends on the melt composition and increases with an increase in the oxide modifier concentration.
  相似文献   
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