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51.
As many as 230 patients with disseminated sclerosis were examined in the Transcarpathian region. Sick male- and female populations were found out to be almost similar. There were more sick persons in the medium-range areas of the Carpathian Mountains, with a mean age being 35 +/- 5 years. It has been established that intake of spirulina makes for lengthening of remission in those patients with disseminated sclerosis. 相似文献
52.
AA Zargarov II Senin AM Alekseev SV Shul''ga-Morsko? PP Filippov VM Lipkin 《Canadian Metallurgical Quarterly》1996,22(7):483-488
Numerous data strongly suggest the involvement of cytokines and the matrix metalloproteinase collagenase (MMP-1) in the pathogenesis of periodontitis. Recently, we have demonstrated that, upon culturing under the influence of IL-1 alpha + EGF, a large amount of inactive procollagenase (MMP-1) is stored in the extracellular matrix of periosteal tissue. We now show that this endogenous reservoir of proenzyme can be operative after activation with plasmin and is able to induce a rapid and almost complete breakdown of the collagenous extracellular matrix. The level of collagen degradation following activation showed a strong correlation with the amount of proenzyme that was incorporated in the tissue. The highest level of degradation (70% of the total amount of collagenous proteins) was found with the IL-1 alpha + EGF-treated explants, followed by those treated with IL-1 alpha alone (35%). Explants cultured with EGF or in the absence of cytokines, containing only small amounts of procollagenase, showed little collagen breakdown following plasmin activation (7%). Inhibition of metalloproteinases by EDTA, or blockage of plasmin by PMSF, prevented the degradation in all explants irrespective of the amount of proenzyme present in the tissue. Our findings demonstrate that endogenous proenzyme stored in a native connective tissue matrix can be activated at a later time interval which results in a massive breakdown of the tissue. This study shows a possible pathway of collagenase-induced breakdown without recent de novo synthesis of the enzyme. Such a sequence may be operative in chronic inflammatory diseases, such as periodontitis, where production of procollagenase under the influence of cytokines spans a longer time period, whereas breakdown is often characterized by a cyclic behaviour. 相似文献
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The study was conducted in 55 patients with cardiac pains. Electrocardiography was used successively prior to, during and following physical exercises, followed by Seldinger selective coronary angiography, and electrocardiography prior to, during and following hyperventilation tests. In 2 of 55 patients the result of the exercise test was interpreted as false-positive, since the coronary angiography demonstrated intact vessels, and during hyperventilation ECG recorded a decreased ST segment. To avoid false-positive results in patients with suspected angina pectoris the physical exercises tests can be considered positive only in cases in which hyperventilation caused no ECG changes typical for angina pectoris. 相似文献
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Sizer T. II Kafka J. Duling I. III Gabel C. Mourou G. 《Quantum Electronics, IEEE Journal of》1983,19(4):506-511
In high-gain dye amplifiers, the effective storage time of the gain medium is only a few hundred picoseconds. Therefore, efficient amplification of ultrashort pulses places a stringent requirement on the synchronization between the pump pulse and the pulse to be amplified. We present a technique of short pulse generation using a dye laser synchronously pumped by a frequency-doubled CW mode locked Nd:YAG laser. Pulses as short as 70 fs are produced. The short optical pulses are subsequently amplified with two different synchronous amplification schemes using 100 ps pulses to establish the gain in the dye amplifier stages. Subpicosecond pulses with energies from a few hundred nanojoules at 500 Hz to a few hundred microjoules at 7 Hz can be obtained. 相似文献
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II Gitel'zon VP Nefedov VV Mezhevikin VA Samo?lov IuV Kotlovski? 《Canadian Metallurgical Quarterly》1977,84(7):23-24
Hypoxemia (45-minute) influence in vivo on erythropoietic activity of the kidney, liver, spleen, and sternum was studied by normoxemic perfusion of the isolated organs. The erythropoietic activity proved to increase after 6-hour perfusion of the liver; this confirmed the participation of this organ in the extrarenal secretion of the erythropoietic factor. 相似文献
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Josh A. Pihl Jennifer A. Lewis Todd J. Toops James E. Parks II 《Topics in Catalysis》2013,56(1-8):89-93
The primary technical barrier to deployment of fuel saving lean gasoline engines is NOx emissions control. We conducted automated flow reactor experiments on a commercial LNT catalyst to identify opportunities and challenges associated with the higher temperatures and higher NOx concentrations expected in lean gasoline applications. Overall NOx conversion was quite high at low to moderate temperatures, but dropped off at high temperatures. The decrease in NOx conversion with temperature was worse for higher inlet NOx concentrations. As expected from equilibrium considerations, the catalyst stored more NOx under higher gas phase NOx concentrations, but that NOx was rapidly released during the rich phase and slipped out of the catalyst before it could be converted to N2 by incoming reductant. This rich phase NOx release was the primary factor limiting performance of the catalyst at high temperatures, and resulted in significant spikes of NOx that would likely exceed any not-to-exceed regulated emissions levels. N2O production was also significant, and increased with NOx concentration. The catalyst made very little NH3 at high temperatures. NH3 yield was significant at the lowest operating temperature studied, but it decreased with increasing NOx concentration. 相似文献