Determination of DNA damage in F344 rats induced by geometric isomers of tamoxifen and analogues

The transformation of Trypanosoma cruzi epimastigotes to mammal-infective metacyclic trypomastigotes (metacyclogenesis) can be performed in vitro under chemically defined conditions (TAU 3AAG medium). During this process, changes in the nature of cell surface sugar composition and sugar distribution was evaluated using FITC and gold-labeled lectins and observed by flow cytometry and transmission electron microscopy. The pattern of labeling with the lectins from Triticum vulgaris (WGA), Arachis hypogaea (PNA), Limax flavus (LFA), Canavalia ensiformis (Con-A), and Ricinus communis (RCA-I) significantly changed during the metacyclogenic process. The results obtained are discussed in relation to the role played by T. cruzi cell surface carbohydrate residues on the process of parasite-host cell interaction.     

FPGA在超声气体温度测量中的应用

现场可编程门阵列FPGA(Field Programmable Gate Array)是新一代可编程ASIC器件,它综合了分立器件和大规模集成芯片的优点,在数字电路设计中应用极其广泛.在超声温度测量系统中,应用数字移相技术,结合现场可编程门阵列器件(FPGA)设计了一个高速计数器,实现燃烧气体温度的快速、准确测量.     

Mathematical Modeling of Mutually Influencing Elements by the Fundamental Parameter Method for X-Ray Fluorescence Analysis of High-Entropy AlCrFeCoNiCu Alloy

Powder Metallurgy and Metal Ceramics - A mathematical model and a software program (FLUOR81) were developed to implement the fundamental parameter method for X-ray fluorescence analysis of new...     

The efficacy of recombinant vaccines against hepatitis B and the results of their use in a schedule for pediatric prophylactic inoculations

The results of field clinical trials of Russian and American yeast vaccines against hepatitis B are presented. The study revealed that both vaccines were faintly reactogenic, safe and exhibited high immunological activity. After the full course of immunization following the schedule 0-1-2 months 92.5% and 97.5% of patients receiving, respectively. Russian vaccine "Combiotech" and American vaccine "H-B-Vax II" were found to have specific antibodies. The maximum effect was registered when the vaccines were introduced according to the schedule 0-1-6 months. Seroconversions were observed in 97.5% and 100% of the vaccinees receiving the Russian and American vaccines respectively, in the latter case the highest antibody level being observed. The use of the vaccines within the prophylactic immunization schedule showed that antibodies to hepatitis B appeared in immunized children in 93-100% of cases. Seroconversion indices and the levels of antibodies to diphtheria, tetanus, poliomyelitis and measles were statistically significant and were the same in children receiving only the vaccines according to the immunization schedule and in children immunized, in addition to these vaccines, against hepatitis B.     

Spontaneous Emission and Lasing of a Two-Wavelength Quantum-Cascade Laser

Semiconductors - The results of experiments on the fabrication (by molecular-beam epitaxy) and investigation of the heterostructures of a two-frequency quantum-cascade laser produced on the basis...     

Spectral Shift of Quantum-Cascade Laser Emission under the Action of Control Voltage

Technical Physics Letters - Spectral redistribution of the intensity of short- and long-wavelength emission components within gain bandwidth of a 7- to 8-μm quantum-cascade laser under the...     

Nucleotide variation in the triosephosphate isomerase (Tpi) locus of Drosophila melanogaster and Drosophila simulans

DNA sequence variation in a 1.1-kb region including the coding portion of the Tpi locus was examined in 25 homozygous third-chromosome lines of Drosophila melanogaster, nine lines of Drosophila simulans, and one line of Drosophila yakuba. Our data show that the widespread allozyme polymorphism observed in cosmopolitan D. melanogaster is due to a glutamic acid substitution occurring in a phylogenetically conserved lysine that has been identified as part of the "hinged-lid" active site of the enzyme. This observation suggests that the replacement polymorphism may have important functional consequences. One replacement polymorphism was also observed in D. simulans, although its functional relevance is more difficult to assess, since it affects a site that is not strongly conserved. This amino acid change in D. simulans is associated with a single lineage possessing seven unique silent substitutions, which may be indicative of balancing selection or population subdivision. The absence of fixed amino acid differences between D. melanogaster and D. simulans and only a single difference with D. yakuba suggests that triose phosphate isomerase is under strong functional constraint. Silent variation is slightly higher for D. melanogaster than for D. simulans. Finally, we outline the general lack of evidence for old balanced polymorphisms at allozyme loci in D. melanogaster.     

FREE VIBRATION ANALYSIS OF KIRCHHOFF PLATES RESTING ON ELASTIC FOUNDATION BY MIXED FINITE ELEMENT FORMULATION BASED ON GÂTEAUX DIFFERENTIAL

The main objective of the present work is to give the systematic way for derivation of Kirchhoff plate-elastic foundation interaction by mixed-type formulation using the Gâteaux differential instead of well-known variational principles of Hellinger–Reissner and Hu–Washizu. Foundation is a Pasternak foundation, and as a special case if shear layer is neglected, it converges to Winkler foundation in the formulation. Uniform variation of the thickness of the plate is also included into the mixed finite element formulation of the plate element PLTVE4 which is an isoparametric C⁰ class conforming element discretization. In the dynamic analysis, the problem reduces to solution of the standard eigenvalue problem and the mixed element is based upon a consistent mass matrix formulation. The element has four nodes and at each node transverse displacement two bending and one torsional moment is the basic unknowns. Proper geometric and dynamic boundary conditions corresponding to the plate and the foundation is given by the functional. Performance of the element for bending and free vibration analysis is verified with a good accuracy on the numerical examples and analytical solutions present in the literature. © 1997 by John Wiley & Sons, Ltd.     

基于PLC的碱回收蒸发工段控制系统的设计

根据某造纸厂碱回收蒸发工段的工艺流程和控制要求,从系统硬件组态和软件设计两方面探讨了Simatic S7-300在碱回收蒸发过程中的应用;针对蒸发工段的出效浓黑液浓度难以控制的特点,提出了黑液浓度基于串级控制策略;利用WinCC组态软件实现上位机监控,模拟现场画面,显示所需监控的现场设备.经过运行表明,该系统调节准确,稳定了黑液浓度,降低了能耗,同时节约了设备投资.