Counting clicks and beeps: Exploring numerosity based haptic and audio PIN entry

Haptic and audio cues now appear commonly in computer interfaces, partially due to inherent advantages such as their support for eyes-free interaction. Their invisible, unobservable nature also makes them ideal candidates for security interfaces in which users have to enter secret information such as passwords. In particular, researchers have explored this idea through the design of PIN entry authentication systems based on multi-modal combinations of visual and non-visual content or on the recognition of small sets of unimodal haptic or audio stimuli. This paper highlights the benefits and performance limitations of these approaches and introduces an alternative based on unimodal audio or haptic temporal numerosity – the ability to accurately and rapidly determine the number of cues presented in rapid temporal succession. In essence, in a numerosity interface, rather than recognizing distinct cues, users must count the number of times that a single cue occurs. In an iterative process of design and evaluation, three prototypes implementing this concept are presented and studies of their use reported. The results show the fastest PIN entry times and lowest error rates to be 8 s and 2%, figures that improve substantially on previous research. These results are attained while maintaining low levels of workload and substantial resistance to observation attack (as determined via camera attack security studies). In sum, this paper argues that unimodal audio and haptic numerosity is a valuable and relatively unexplored metaphor for non-visual input and demonstrates the validity of this claim in the demanding task of unobservable authentication systems.     

Comparative Optimism About Health and Nonhealth Events in 8- and 9-Year-Old Children.

Comparative optimism has been studied extensively in adults and is a significant component of social- cognitive models about health. In contrast, little is known about comparative optimism in children or about the wider social- cognitive processes that underpin their health-related behavior. This study investigated comparative optimism for health- and nonhealth-related topics in 101 children 8 or 9 years of age, the youngest ages that have been investigated so far. Children were shown to be unrealistically optimistic for health and nonhealth events. The implications of these findings for understanding comparative optimism in children are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Towards quality requirements via animated formal specifications

Assuring a high quality requirements specification document involves both an early validation process and an increased level of participation. An approach and its supporting environment which combines the benefits of a formal system specification and its subsequent execution via a rapid prototype is reported. The environment assists in the construction, clarification, validation and visualisation of a formal specification. An illustrative case study demonstrates the consequences of assertions about system properties at this early stage of software development. Our approach involves the pragmatic combination of technical benefits of formal systems engineering based techniques with the context‐sensitive notions of increased participation of both developer and user stakeholders to move us closer towards a quality requirements specification document.     

Modelling and solving English Peg Solitaire

Peg Solitaire is a well known puzzle, which can prove difficult despite its simple rules. Pegs are arranged on a board such that at least one ‘hole’ remains. By making draughts/checkers-like moves, pegs are gradually removed until no further moves are possible or some goal configuration is achieved. This paper considers the English variant, consisting of a board in a cross shape with 33 holes. Modelling Peg Solitaire via constraint or integer programming techniques presents a considerable challenge and is examined in detail. The merits of the resulting models are discussed and they are compared empirically. The sequential nature of the puzzle naturally conforms to a planning problem, hence we also present an experimental comparison with several leading AI planning systems. Other variants of the puzzle, such as ‘Fool's Solitaire’ and ‘Long-hop’ Solitaire are also considered.     

Velocity Distribution in the Roughness Layer of Rough-Bed Flows

Several models for the vertical distribution of the double-averaged (in time and in the plane parallel to the mean bed) longitudinal velocity in the flow region between roughness troughs and roughness tops are suggested. We found that the same model for velocity distribution may be applicable to a range of flow conditions and roughness types, which share some common features. The suggested models for velocity distribution in the near-bed region are: (1) Constant velocity; (2) exponential velocity distribution; and (3) linear velocity distribution. The measured velocity distributions may be approximated by a single model or by a combination of models depending on roughness geometry and flow conditions. The validity of these models for velocity distribution is supported by laboratory data.     

Nanoparticle-functionalized porous polymer monolith detection elements for surface-enhanced Raman scattering

The use of porous polymer monoliths functionalized with silver nanoparticles is introduced in this work for high-sensitivity surface-enhanced Raman scattering (SERS) detection. Preparation of the SERS detection elements is a simple process comprising the synthesis of a discrete polymer monolith section within a silica capillary, followed by physically trapping silver nanoparticle aggregates within the monolith matrix. A SERS detection limit of 220 fmol for Rhodamine 6G is demonstrated, with excellent signal stability over a 24 h period. The capability of the SERS-active monolith for label-free detection of biomolecules was demonstrated by measurements of bradykinin and cytochrome c. The SERS-active monoliths can be readily integrated into miniaturized micrototal-analysis systems for online and label-free detection for a variety of biosensing, bioanalytical, and biomedical applications.     

MicroRNA-Based Diagnosis and Therapy

MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene expression. Alteration in miRNA expression results in changes in the profile of genes involving a range of biological processes, contributing to numerous human disorders. With high stability in human fluids, miRNAs in the circulation are considered as promising biomarkers for diagnosis, as well as prognosis of disease. In addition, the translation of miRNA-based therapy from a research setting to clinical application has huge potential. The aim of the current review is to: (i) discuss how miRNAs traffic intracellularly and extracellularly; (ii) emphasize the role of circulating miRNAs as attractive potential biomarkers for diagnosis and prognosis; (iii) describe how circulating microRNA can be measured, emphasizing technical problems that may influence their relative levels; (iv) highlight some of the circulating miRNA panels available for clinical use; (v) discuss how miRNAs could be utilized as novel therapeutics, and finally (v) update those miRNA-based therapeutics clinical trials that could potentially lead to a breakthrough in the treatment of different human pathologies.     

ICOSL Stimulation by ICOS-Fc Accelerates Cutaneous Wound Healing In Vivo

Background: ICOS and its ligand ICOSL are immune receptors whose interaction triggers bidirectional signals that modulate the immune response and tissue repair. Aim: The aim of this study was to assess the in vivo effects of ICOSL triggering by ICOS-Fc, a recombinant soluble form of ICOS, on skin wound healing. Methods: The effect of human ICOS-Fc on wound healing was assessed, in vitro, and, in vivo, by skin wound healing assay using ICOS^−/− and ICOSL^−/− knockout (KO) mice and NOD-SCID-IL2R null (NSG) mice. Results: We show that, in wild type mice, treatment with ICOS-Fc improves wound healing, promotes angiogenesis, preceded by upregulation of IL-6 and VEGF expression; increases the number of fibroblasts and T cells, whereas it reduces that of neutrophils; and increases the number of M2 vs. M1 macrophages. Fittingly, ICOS-Fc enhanced M2 macrophage migration, while it hampered that of M1 macrophages. ICOS^−/− and ICOSL^−/− KO, and NSG mice showed delayed wound healing, and treatment with ICOS-Fc improved wound closure in ICOS^−/− and NSG mice. Conclusion: These data show that the ICOS/ICOSL network cooperates in tissue repair, and that triggering of ICOSL by ICOS-Fc improves cutaneous wound healing by increasing angiogenesis and recruitment of reparative macrophages.     

Metabolic Pathways for Observed Impacts of Crop Load on Floral Induction in Apple

The triggers of biennial bearing are thought to coincide with embryonic development in apple and occurs within the first 70 days after full bloom (DAFB). Strong evidence suggests hormonal signals are perceived by vegetative apple spur buds to induce flowering. The hormonal response is typically referred to as the floral induction (FI) phase in bud meristem development. To determine the metabolic pathways activated in FI, young trees of the biennial bearing cultivar ‘Nicoter’ and the less susceptible cultivar ‘Rosy Glow’ were forced into an alternate cropping cycle over five years and an inverse relationship of crop load and return bloom was established. Buds were collected over a four-week duration within 70 DAFB from trees that had maintained a four-year biennial bearing cycle. Metabolomics profiling was undertaken to determine the differentially expressed pathways and key signalling molecules associated with biennial bearing. Marked metabolic differences were observed in trees with high and low crop load treatments. Significant effects were detected in members of the phenylpropanoid pathway comprising hydroxycinnamates, salicylates, salicylic acid biosynthetic pathway intermediates and flavanols. This study identifies plant hormones associated with FI in apples using functional metabolomics analysis.