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61.
R Hui JR Ball RD Macmillan FS Kenny OW Prall DH Campbell AL Cornish RA McClelland RJ Daly JF Forbes RW Blamey EA Musgrove JF Robertson RI Nicholson RL Sutherland 《Canadian Metallurgical Quarterly》1998,17(8):1053-1059
The EMS1 and CCND1 genes at chromosome 11q13 are amplified in about 15% of primary breast cancers but appear to confer different phenotypes in ER positive and ER negative tumours. Since there are no published data on EMS1 expression in large series of breast cancers we examined the relationship of EMS1 expression with EMS1 gene copy number and expression of mRNAs for cyclin D1 and ER. In a subset of 129 patients, where matched tumour RNA and DNA was available, EMS1 mRNA overexpression was associated predominantly with gene amplification (P = 0.0061), whereas cyclin D1 mRNA overexpression was not (P = 0.3142). In a more extensive series of 351 breast cancers, there was no correlation between cyclin D1 and EMS1 expression in the EMS1 and cyclin D1 overexpressors (P = 0.3503). Although an association between EMS1 mRNA expression and ER positivity was evident (P = 0.0232), when the samples were divided into quartiles of EMS1 or cyclin D1 mRNA expression, the increase in the proportion of ER positive tumours in the ascending EMS1 mRNA quartiles was not statistically significant (P = 0.0951). In marked contrast there was a significant stepwise increase in ER positivity in ascending quartiles of cyclin D1 mRNA (P = 0.030). A potential explanation for this difference was provided by the observation that in ER positive breast cancer cells oestradiol treatment resulted in increased cyclin D1 gene expression but was without effect on EMS1. The relationship between EMS1 expression and clinical outcome was examined in a subset of 234 patients with median follow-up of 74 months. High EMS1 expression was associated with age > 50 years (P = 0.0001), postmenopausal status (P = 0.0008), lymph node negativity (P = 0.019) and an apparent trend for worse prognosis in the ER negative subgroup. These data demonstrate that overexpression of EMS1 mRNA is largely due to EMS1 gene amplification, is independent of cyclin D1 and ER expression and, in contrast to cyclin D1, is not regulated by oestrogen. Independent overexpression of these genes may confer different phenotypes and disease outcomes in breast cancer as has been inferred from recent studies of EMS1 and CCND1 gene amplification. 相似文献
62.
Salvatore A. Bruno Donald K. Swanson Ian Burn 《Journal of the American Ceramic Society》1993,76(5):1233-1241
Advantages of chemically prepared powders for electronic ceramics have been demonstrated for a number of multilayer capacitor (MLC) dielectrics. A cost-efficient precipitation process was developed to produce undoped or doped crystalline barium titanate powder with a narrow particle size distribution close to 0.5 μm. More complex compositions, e.g., barium-neodymium titanate, were amorphous as precipitated but could be crystallized by calcination below 1000°C. Additional compositional modifications, to adjust electrical properties or to lower sintering temperature, were accomplished by doping the surface of the powder particles using a solution coating process. Exceptional fired densities and electrical performance were obtained. 相似文献
63.
The synthesis and realization of an analog-phase shifter, delay line, attenuator, and group delay synthesizer-are presented. These variable control devices are all implemented using the same generic single stage reflection topology. The optimum conditions of operation have been determined and the corresponding group delay behaviors have been investigated to produce simple design equations. As proof-of-concepts, monolithic technology has been used to realize an X-band, phase shifter, delay line, and attenuator. Hybrid technology has been used to realize an L-band, group-delay synthesizer. Because of the high levels of performance measured, these control devices are ideally suited for use as general building blocks in adaptive signal processing applications, including large phased array applications 相似文献
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MM Clark BT Santamaria RK Robertson BG Galef 《Canadian Metallurgical Quarterly》1998,112(4):1026-1029
When assuming a species-typical tripodal posture, female Mongolian gerbils most often rest on their left forepaws and hold their right forelimbs aloft; male gerbils most often do the reverse. This experiment examined effects of gonadectomy, both in infancy and in adulthood, on the sexually dimorphic asymmetry in forelimb use by Mongolian gerbils when maintaining a tripodal stance. In adulthood, both male and female gerbils that had been gonadectomized at birth reversed their forelimb use while in a tripodal stance: Gonadectomized males used their forelimbs as did sham-operated females, and gonadectomized females used their forelimbs as did sham-operated males. Gonadectomy in adulthood abolished the sexual dimorphism in forelimb use seen in sham-operated subjects. It was concluded that gonadal hormones have organizational as well as possible activational effects on adult patterns of forelimb use by gerbils. 相似文献
66.
Hongjie Li Arthur E. Morris David G. C. Robertson 《Metallurgical and Materials Transactions B》1998,29(6):1181-1191
The thermodynamics of MnO-containing slags was reviewed, and the properties of such slags were correlated by application of
the cell model. This model, together with a previously developed unified interaction parameter model for the metal phase,
was used to simulate the gas-slag-metal conditions in the hearth of a ferromanganese submerged arc furnace. The calculated
slag and metal compositions and distribution of Mn, Si, and K between slag, metal, and fume were compared with plant data
and satisfactory agreement was obtained. A steady recirculation of potassium inside the furnace was also predicted. For a
potassium percentage in the raw materials of 0.63 pct, the amount of the recirculating potassium was about 160 kg per metric
ton of ferromanganese. Due to the recirculation, the average potassium content in the solid mix coming down to the hearth
could be as high as 7 pct. 相似文献
67.
The magnetomechanical effect for a quenched and tempered alloy steel has been studied. In most published work it has been found that stress causes the magnetization to move toward the anhysteretic magnetization. However, in the present work it was found that under special conditions the magnetization moves away from the anhysteretic when a cyclic stress is applied. This behavior is tentatively explained by applying the Preisach model of ferromagnetic hysteresis 相似文献
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Jarvis Tyler Clough Jordan Cox Jane Petersen Konnor Sailsbery Mitchell Robertson Connor Moncur Tyler Palmer Katie Lund Darren 《Water Resources Management》2021,35(2):745-756
Water Resources Management - A traditional cost-benefit analysis of potential water interventions in a given locality is a laborious and time-intensive process. To help decision makers identify... 相似文献