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41.
SA Afanas''ev IuB Lishmanov TV Lasukova AV Naumova 《Canadian Metallurgical Quarterly》1997,123(5):514-517
This study was performed to investigate the capability of iontophoretic delivery of prostaglandin E1 (PGE1) and the effect of this treatment on the viability of skin flaps on the rat dorsum model as described by Hammond and Ronald in 1993. The PGE1 level in the tissue sample under the electrode was assessed with radioimmunoassay. The iontophoretic treatment (for 20 minutes at 4 mA) with PGE1 solution (20 micrograms PGE1 in 2 ml saline) showed a significant increase of PGE1 in the flap tissue under the negative electrode (p < 0.05). Very little increase was observed after the iontophoresis of saline alone. This was not statistically significant. Iontophoretic treatment was given for 5 consecutive days following flap elevation. The survival area on the seventh postoperative day was significantly greater in the PGE1-treated flaps than that of either the control or saline-treated flaps. These results confirm the beneficial effect of iontophoretic treatment with PGE1 on the augmentation of skin flap viability. 相似文献
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The species composition of microflora was determined and the etiological role of S. epidermidis was shown in some purulent inflammatory diseases (maxillary sinusitis, urethritis). The role of the complex of S. epidermidis persistence factors in the chronization of the infectious process and the formation of the resident carrier state was established. 相似文献
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ESh Ismailov DG Khachirov GE Ismailova IuB Kudriashov 《Canadian Metallurgical Quarterly》1998,38(6):920-923
According to our and other investigators theoretical and experimental dates biophysical effects of microwaves are defined by thermal and specific biological action. Specific influence are realized by more delicate and precise ways and mechanisms of absorption and molecular relaxation of microwave energy, energy-informative interaction of radio-emission with biosystem. It include three mechanisms: synchronisation of oscillatory processes (oscillators) of irradiated object in acting electromagnetic field; selective influence of microwaves on the biomembranes, on nervous and other highly-organized systems of living organism, on the complex formation processes and fermentative activity; resonance phenomena. These mechanisms connected with parameters of acting electromagnetic field and with electrical, magnetic and other properties of biological systems. 相似文献
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Classical neurotransmitters acetylcholine and biogenic monoamines act as multifunctional substances throughout the metazoan ontogenesis. A suggested cyclic scheme describes developmental changes of neurotransmitter functions from the oocyte maturation to neuron formation. 相似文献
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ED Min'kov GB Niu-Tian-de LV Shkhvatsabaia IuB Bagdasarov TI Za?tseva AA Odzharova 《Canadian Metallurgical Quarterly》1994,66(10):64-66
Twenty females with disseminated breast cancer received courses of polychemotherapy with 21-day intervals. The regimen comprised adriamycin (ADM), cyclophosphamide and 5-fluorouracil in the dose 50, 500 mg/m2, respectively. 30 minutes prior to the treatment the patients were given the cardioprotector cardioxan (1000 mg/m2). Cardiological control (ECG, EF according to echo-CG and radionuclide ventriculography, PP/EP M1/M2, T1/T2 according to echo-polycardiography and Doppler cardiography) was performed before the treatment and at ADM total dose 200-300 mg/m2 followed by measurements at each dose increase by 100 mg/m2. The findings showed no evidence of ADM-related cardiac damage up to ADM dose 900-1000 mg/m2 in the case of cardioxan protection, though there was a tendency to M1/M2 increase which needs further studies as it suggests worsening of left ventricular diastolic contractility. 相似文献
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S M Kolomina T M Kalishevskaia Iu S Chentsov B A Kudriashov N Iu Repina 《Eksperimental?nai?a onkologii?a》1984,6(5):69-72
The strong depressive effect of vinblastine on the rat sarcoma 45 growth and intensification of this effect by the combination of vinblastine treatment with the activation of the blood anticoagulating system (BAS) were found. Vinblastine had no negative effect on the BAS activation process and induced no persistent changes in the qualitative content of leucocytes in the peripheral blood. 相似文献
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SN Proshin VIu Kravtsov MG Ol''nev MG Iaklov IuB Vakhtin 《Canadian Metallurgical Quarterly》1998,34(1):61-64
Important advances continue to occur in both our understanding and management of gestational trophoblastic disease. Complete molar pregnancy is being diagnosed earlier in pregnancy which affects its clinical and pathological presentation. The use of chemotherapy in persistent gestational trophoblastic tumors continues to be refined and our understanding of the immunobiology of these tumors has substantially advanced. 相似文献