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A chronic 90-day inhalation of polyethylsiloxane fluid at a concentration of 10 and 2 mg/m3 produced local irritation and general toxic effect on rats. Local irritation induced catarrhal-desqueamative tracheitis that was accompanied by a microfocal interstitial process in the lungs. The general toxic effect gave rise to interstitial myocarditis that was followed by focal cardiosclerosis and dystrophic lesions of vascular walls and areas of liver parenchyma. Changes in the thymus-lymph system and adrenal structure suggested prolonged protective tension of the animal body. A chronic 90-day inhalation of polyethylsiloxane at a concentration of 0.2 mg/m3 brought about no pathological lesions in the microstructure of animal organs. 相似文献
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IuP Kolesnikov 《Canadian Metallurgical Quarterly》1976,117(8):78-80
A method of graphic registration of the length and diameter of vessels of basis cerebri is suggested. The registration is carried out on special cards--punch cards with due account of the structure of the circle of Willis, with subsequent collation of these indices with focal changes in the brain. The method is graphically clear and may be used in research work, as well as in the practice of a pathoanatomist in documentation of an autopsy report and for demonstrations in clinico-anatomical conferences. 相似文献
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IuP Solodovnikov IN Lytkina NN Filatov AV Ivanenko BE Za?tsev 《Canadian Metallurgical Quarterly》1997,40(1):31-35
Herpes simplex virus-1 (HSV-1) glycoprotein E (gE) is a multifunctional protein capable of both binding the Fc portion of IgG and mediating cell-to-cell spread of HSV-1. Here we report that the domain on gE involved in IgG binding is distinct from the domain involved in mediating cell-to-cell spread. To do this we have used five mutants of the HSV-1 strain NS: NS-gE(null), a gE deletion virus; rNS-gE(null), a gE rescued virus; NS-gE339, a gE mutant virus with a four amino acid insert at position 339; rNS-gE339, a gE rescue of NS-gE339; and NS-gE406, a gE mutant virus with the same four amino acids inserted at position 406. Using IgG coated sheep red blood cells in rosetting assays, we show that the NS-gE339 does not bind IgG, yet retains the ability to mediate normal cell-to-cell spread. These results demonstrate that the gE domain involved in IgG binding differs from the domain involved in cell-to-cell spread. 相似文献
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IuP Pereponov EK Taktarov EK Pereponova VV Ferkovich ET Lil'in 《Canadian Metallurgical Quarterly》1998,70(5):62-64
AIM: The study of somatic health in patients with locomotor defects (infantile cerebral paralysis, meningoencephalocele, myodystrophy) to reveal abnormalities in function of the principal systems and organs of these patients. MATERIALS AND METHODS: The examination covered 93 students of Moscow institute for invalids suffering from locomotor defects (mean age 18.2 +/- 0.1 years). Clinical, laboratory, instrumental tests, ultrasound investigation of the viscera and heart, gynecological functional tests were made. RESULTS: Defects were found almost in all the essential systems of the body in the majority of the invalids. The changes revealed were both functional and organic. Relevant correction was needed. Affection of the somatic organs impaired adaptation, resulted in still worse conditions for learning. Attendant somatic diseases aggravated the underlying disease. CONCLUSION: Visceral affections in patients with locomotor defects aggravate the underlying disease and provoke more severe disability. Poor rehabilitation results lead to defective social adaptation. The authors propose introduction of special therapeutic programs for primary and secondary prophylaxis of somatic lesions in invalids with locomotor affections. Further study of somatic status of invalids is thought valid. 相似文献
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