Assessment of the severity of grave cranio-cerebral injury and its outcome according to the state of energy metabolism in the brain]

A dynamic study of the arteriovenous oxygen and lactic acid content difference, as well as a study of the CSF content of the lactic acid in patients with a severe craniocerebral trauma permitted to evaluate the severity of the pathological process and the results of its treatment. A growing production of lactic acid by the brain and its progressive accumulation in the CSF to a high level as 45-50 mg%, and a sharp dissociation between the increasing lactate level in the CSF and its growing concentration in the venous blood flowing from the brain is a prognostic sign of an unfavourable course and outcome of the disease.     

An analysis of the stability of the antigenic structure in productive strain 205 of the tick-borne encephalitis virus during prolonged passage

The stability of the antigenic structure of tick-borne encephalitis (TBE) virus strain 205 in the process of passage through the brain of BALB/c mice has been studied. Its relationships with other viruses of the TBE complex have been analyzed with the use of monoclonal antibodies to virus proteins E and NS3. The stability of the protein structure of the virus has been determined by the immunofluorescence test and the enzyme immunoassay.     

Rol' of the frontal lobe in synchronizing biopotentials in different regions of the dog brain

The role of the frontal cortex in formation of neocortical systemic processes has been studied by the method of sign correlation of the summate electrical activity. A distant EEG synchronization in the temporal and occipital zones sets in following strychninization of F2 zones (but not of Prc2 zones) in anaesthetized dogs or in cerveau isolé preparations. In dogs with elaborated conditioned reflexes a statistically significant distant synchronization of the neocortical EEG sets in during the delay period only in case of well expressed motivation (of hunger in case of food reinforcement, and of thirst in case of water reinforcement). No distant conditioned EEG synchronization was revealed in lobectomised dogs. The role of the frontal cortex in the intracerebral integration is discussed which is necessary for achievement of the forthcoming signal activity.     

Quality of life of relatives of mental patients

Usage of quality of life of psychiatric patients' relatives as the parameter of estimation of the quality of psychiatric care is considered. By means of standard questionnaire elaborated by the authors as well as by means of both individual and group conversations the quality of life was analyzed in 40 relatives which lived together with psychiatric patients. Different spheres of their life and difficulties (financial, social-psychologic, production) were examined in families with such patients. The defects of psychiatric care that had direct influence on the quality of life of the psychiatric patients' relatives are outlined.     

Current problems in organizing the donor system in the Armed Forces

In the work the factors, rendering essential influence on organization of donorship in modern army conditions are systematized. The organization of donorship should be connected to functioning of territorial system of medical maintenance of the Armed Forces of RF. It assumes presence of four organizational levels: central, district, zone and garrison. Perfecting the system of organization of donorship, we should be guided by the following conducting principles: maximum maintenance of safety of donorship; wide introduction of a method of plasmacytopheresis in work of establishments and subdivisions of blood supply service; organization of autodonorship and quota of the donors of an emergency reserve in each military-medical establishment; reliable maintenance of revealing of markers of hemotransmissible infections at inspection of the donors.     

The population genetic aspects of the intestinal microbiological phenotype in healthy humans

The principle of the formation of the microbiological phenotype in the intestine of healthy persons was studied by the method of the population-genetic analysis. The microbial composition of the intestinal flora of healthy members of 10 complete families (altogether 50 persons) was studied. The study revealed that practically in all cases the variability of the qualitative and quantitative characteristics of the phenotype under study on the levels of both genera and individual microbial species is formed mainly under the influence of environmental factors. The presence of indigenous bacteria in the intestinal microbiocenosis (including Escherichia coli with normal enzymatic properties) is strongly genetically determined.