Possiblity of using immobilized urease for degradation of urea in blood plasma

As revealed the velocities of urea decomposition in the citrate donor plasma with soluble urease and urease immobilized by addition to carboxymethyl ester of cellulose, 2-(3'-amino-4'-methoxyphenyl)-sulphonylethyl ester of cellulose, diethylaminoester of cellulose, stained with dichlortriazine stain, or graft copolymere of cellulose and polyglycidylmetacrylate were sufficiently close to one another. Preparations of immobilized urease can be repeatedly used for urea decomposition in the citrate donor blood. Periodical treatment of the mentioned preparations with cystein solution led to a lesser decrease of enzymatic activity of the immobilized urease after repeated use.     

Venous blood return to the heart in focal myocardial ishemia and its effect on the degree of ischemic injury and the size of the ischemic area

It was established in experiments on 14 dogs that the acute character of ischemic damage to the myocardium and the size of the zone of ischemia in occlusion of the coronary artery diminish against the background of reduced venous return to the heart. The reduction in the ischemic area occurs for the most part because of a decrease of the border-line and neutral zones.     

Characteristics of the effect of nitroglycerin on hemodynamics

An examination was conducted of 45 healthy individuals 23 to 28 years of age who received nitroglycerine sublingually in a dose of 0.5 mg (15 persons) and by intravenous drip for one hour in doses of 3, 10, and 20 mg (groups of ten persons). It was shown that the drug had no essential effect on the rate of cardiac contractions and the diastolic arterial pressure. The systolic arterial pressure decreased with the increase of the nitroglycerine dose. The trend and the severity of changes in central hemodynamics were, in most cases, inversely dependent on the volume of cardiac ejection and did not depend on the dose and route of administration of the drug. With a cardiac index of 3 to 5.5 1/min/m2, this index in 71% of individuals reduced by 26% on the average. With an initial cardiac index of 2 to 2.9 1/min/m2, in 63% of individuals this index increased by 27% on the average. The authors distinguish three types of the reaction of hemodynamics to the administration of nitroglycerine: hypo-, hyper-, and eucardiac.     

Role of artificial pulmonary ventilation in mechanisms of development of generalized activity of limbic origin in postresuscitative states

It was shown in experiments on 25 dogs that the generalized a-like limbic activity is recorded on ECoG in the post-resuscitation period after 12-minute cardiac arrest largely in the cases of forced spontaneous breathing. The use of large tidal volumes of artificial lung ventilation during resuscitation significantly diminished frequency of the appearance on ECcG of the activity in question because of hypccapnia and resultant suppression of the respiratory centre. The forced work of the respiratory centre is conducive to the development of this activity by irradiating the excitaticn to the higher brain structures.     

Pathogenesis of nervous system lesions in epidemic parotitis in children

The authors studied antibodies to the nervous tissue in the blood (pair serum with an interval of 10 days) and in the CSF in 155 patients with epidemic parotitis and signs of neurotoxicosis, parotit meningitis and meningoencephalitis. Depending upon the intensivity of antibody elaboration 3 groups were distinguished. The first group (40 cases), with a high content of antibodies to the nervous tissue, was characterized by a prevalence of encephalitic forms (in 30 of the 40 cases). In the second group (32 cases) with a less antibody content there was a prevalence of meningitis, while meningoencephalitis was seen only in 3 cases. The third group (83 cases) with a low concentration or absence of antibodies was characterized by a mild course of the disease. This group included as well patients with neurotoxicosis. These data may indicate involvement of allergic mechanisms of a retarded type in the pathogenesis of remote lesions of the nervous system in epidemic parotitis.     

Vestibular vertigo in patients with autonomic crises

Responding to demands that nursing leaders conduct business in creative proactive ways, the authors of this department share the work of The Robert Wood Johnson Foundation's national program, Colleagues in Caring: Regional Collaboratives for Nursing Work Force Development. The purpose of this initiative is to enhance regional and state collaborative planning and implement actions and policies to address the rapid changes occurring in the United States nursing labor market. This department, edited by Mary Fry Rapson, PhD, RN, CS, National Program Director and Rebecca B. Rice, EdD, RN, National Deputy Director, presents the ongoing work of the program, highlighting the work of the 20 individual collaboratives. Regional approaches to the expected program outcomes and specific challenges and opportunities that are unique to each region's environment are included.     

Radiation-surgical treatment of certain forms of malignant tumors

The altitude resistance of albino rats was studied via measurements of their altitude threshold on the 3rd, 7, 15, 30, 45th days of their step-by-step acclimatization to highlands (Tuya-Ashu pass at an altitude of 3200 m), on the 3rd, 7, 15, 30, 45th days of their nonstep-by-step acclimatization at the Tuya-Ashu pass and on the 3rd, 7, 15, 30, 45th days of their altitude chamber training. The step-by-step acclimatization of animals included their 15-day exposure to an altitude of 2200 m and subsequent stay in lowlands where their altitude threshold was recorded on the 3rd, 10, 20 30, 40, 60, 80th days. The data obtained indicate that step-by-step acclimatization to highlands results in a more significant increase of the altitude resistance of the animal body and a longer maintenance of the resistance on return to lowlands.