Numerical prediction of turbulent flow and heat transfer in helically coiled pipes

Computational results were obtained for turbulent flow and heat transfer in curved pipes, representative of helically coiled heat exchangers. Following a grid refinement study, grid independent predictions from alternative turbulence models (k–?, SST k–ω and RSM–ω) were compared with DNS results and experimental pressure drop and heat transfer data. Using the SST k–ω and RSM–ω models, pressure drop results were in excellent agreement with literature data and the Ito correlation. For heat transfer, the literature is not comparably complete or accurate, but a satisfactory agreement was obtained in the range of available data. Unsatisfactory results, both for pressure drop and heat transfer, were given by the k–? model with wall functions. Following the validation study, the RSM–ω model was used to compute friction coefficients and Nusselt numbers in the range Re = 1.4·10⁴–8·10⁴, Pr = 0.7–5.6 and δ (coil curvature) = 3·10^?3–0.3. Power-law correlations were found unsuitable to fit the Re-, Pr- and δ-dependence of the Nusselt number, while the use of a properly formulated momentum-heat transfer analogy collapsed all results with high accuracy.     

Version control in project-based learning

This paper deals with the development of a generalized model for version control systems application as a support in a range of project-based learning methods. The model is given as UML sequence diagram and described in detail. The proposed model encompasses a wide range of different project-based learning approaches by assigning a supervisory role either to instructor or students in different project stages. Different strategies for supervisor role assignment are given. Project duration, project milestones, as well as a number of team members are discussed in respect to project-based learning method that the proposed model supports. Possible implementations of different project-based learning approaches on the proposed model are demonstrated by setting the model parameters. Version control server security issues are discussed in the manner of implementation aspects of the proposed model. One of possible model implementations is evaluated in respect of cooperation on the test group of 21 students. Implementation details are presented and compared with other approaches. Mentoring and monitoring students efforts during the development by implementing proposed model with specific model settings introduces controlled cooperation with high clarity in evaluation of individual students work. Using open source version control software on Linux platform, with web interface package, we implemented a low-cost support for project-based learning.     

Variation in fatty acid composition of ewes' milk during continuous transition from dry winter to natural pasture diet

The profile variations of approximately 70 fatty acids (FAs) in milk of ewes consuming total mixed rations (TMR) and grazing natural pasture were determined. Milk of ewes grazing pasture in May and September in the Slovak Republic contained 3-times more conjugated linoleic acid (CLA) (P < 0.001) and trans-vaccenic acid (TVA) (P < 0.001), and 2-times more α-linolenic acid (ALA) (P < 0.001) than that of ewes fed TMR. A doubling of the CLA and TVA contents of milk of ewes fed with TMR was achieved by changing to meadow hay containing a higher ALA content. Less availability of vegetation and lower ALA pasture content in summer (P < 0.001) caused a 2-fold decrease (P < 0.001) of CLA and TVA contents when compared with data obtained in May. With grass re-growth and an increase in pasture ALA content in September, the CLA and TVA contents rose to values similar to those obtained in May (P > 0.05). No significant differences in the FA composition in milk of ewes grazing on summer pasture at higher altitude were observed.     

Power,Responsibility, and Governance in Britain's New Urban Policy

Competition became a major feature of urban policy in Britain during the 1990s. The stimulus of competition was intended to improve regeneration policies, partly by galvanizing the collective resources of local actors. This article draws upon the findings of recent empirical studies of regeneration programs and partnerships to consider the implications of competitive urban policy for the theory and practice of governance. It is argued that promoting partnerships among local institutions and improving the quality of regeneration schemes through competition require positive support from central government. The responsibility for tackling difficult urban problems cannot simply be devolved to underfunded local initiatives.     

Ecological Adaptations of Gut Microbiota Members and Their Consequences for Use as a New Generation of Probiotics

In this review, we link ecological adaptations of different gut microbiota members with their potential for use as a new generation of probiotics. Gut microbiota members differ in their adaptations to survival in aerobic environments. Interestingly, there is an inverse relationship between aerobic survival and abundance or potential for prolonged colonization of the intestinal tract. Facultative anaerobes, aerotolerant Lactobacilli and endospore-forming Firmicutes exhibit high fluctuation, and if such bacteria are to be used as probiotics, they must be continuously administered to mimic their permanent supply from the environment. On the other hand, species not expressing any form of aerobic resistance, such as those from phylum Bacteroidetes, commonly represent host-adapted microbiota members characterized by vertical transmission from mothers to offspring, capable of long-term colonization following a single dose administration. To achieve maximal probiotic efficacy, the mode of their administration should thus reflect their natural ecology.     

Regulatory Noncoding and Predicted Pathogenic Coding Variants of CCR5 Predispose to Severe COVID-19

Genome-wide association studies (GWAS) found locus 3p21.31 associated with severe COVID-19. CCR5 resides at the same locus and, given its known biological role in other infection diseases, we investigated if common noncoding and rare coding variants, affecting CCR5, can predispose to severe COVID-19. We combined single nucleotide polymorphisms (SNPs) that met the suggestive significance level (P ≤ 1 × 10⁻⁵) at the 3p21.31 locus in public GWAS datasets (6406 COVID-19 hospitalized patients and 902,088 controls) with gene expression data from 208 lung tissues, Hi-C, and Chip-seq data. Through whole exome sequencing (WES), we explored rare coding variants in 147 severe COVID-19 patients. We identified three SNPs (rs9845542, rs12639314, and rs35951367) associated with severe COVID-19 whose risk alleles correlated with low CCR5 expression in lung tissues. The rs35951367 resided in a CTFC binding site that interacts with CCR5 gene in lung tissues and was confirmed to be associated with severe COVID-19 in two independent datasets. We also identified a rare coding variant (rs34418657) associated with the risk of developing severe COVID-19. Our results suggest a biological role of CCR5 in the progression of COVID-19 as common and rare genetic variants can increase the risk of developing severe COVID-19 by affecting the functions of CCR5.     

Simulation of a LHP-based thermal control system under orbital environment

In this paper, a thermal control system, using loop heat pipe as basic heat transfer elements, was designed for Alpha Magnetic Spectrometer. A system level model, which is integrated with the International Space Station model, was built, optimized and used to analyze several typical cases representing the orbital environment, to understand the operation of the LHP-based thermal control system during the mission time. The LHP system was proved to be able to maintain the Cryocooler within the required temperature range in most cases, while under some worst cold environments, the bypass valve needs to be activated.     

Effect of dopants on alumina grain boundary sliding: implications for creep inhibition

We investigate by means of periodic density functional theory the mechanism of grain boundary sliding along the α-alumina Σ11 tilt grain boundary. We identify minimum and maximum energy structures along a preferential sliding pathway for the pure grain boundary, as well as for grain boundaries doped with a series of early transition metals, as well as barium, gadolinium, and neodymium. We predict that the segregation of those dopants results in a considerable increase in the grain boundary sliding barrier. Grain boundary sliding occurs by a series of bond breaking and forming across the grain boundary. Our results suggest that the presence of large cations inhibits the regeneration of bonds during sliding, which results in a decrease in total number of bonds across the grain boundary interface, thereby raising the barrier to sliding. Trends in predicted grain boundary sliding energies are in good agreement with recently measured creep activation energies in polycrystalline alumina, lending further credence to the notion that grain boundary sliding plays a dominant role in alumina creep.     

The Influence of Disorder on Thermotropic Nematic Liquid Crystals Phase Behavior

We review the theoretical research on the influence of disorder on structure and phase behavior of condensed matter system exhibiting continuous symmetry breaking focusing on liquid crystal phase transitions. We discuss the main properties of liquid crystals as adequate systems in which several open questions with respect to the impact of disorder on universal phase and structural behavior could be explored. Main advantages of liquid crystalline materials and different experimental realizations of random field-type disorder imposed on liquid crystal phases are described.     

The impact of drying and steaming processes on surface color changes of tension and normal beech wood

Abstract

Beech wood has a high frequency of defects such as red heartwood, reaction wood (tension wood). For the experimental measurements four logs without visible defects like red heartwood, which can noticeably affects the measurements' results were qualified. The drying medium temperature in the first phase of the process before the moisture content of the specimens fell below the FSP was maintained at 45?°C. Then, the temperature was gradually increased to the maximum value 65?°C. The results showed that different initial wood moisture content does not affect to final value of tension and normal wood. The colorimetric parameter L* was much higher for tension wood. After steaming, there were greater differences in the colorimetric parameters, respectively, a* and b*. After drying the difference of all colorimetric parameters between tension and normal wood was significantly less. The color changes were only noticed in the surface layers of specimens. Differences were small, and thus, the impact of the tension wood on the color changes was not confirmed. However, since the lightness of tension wood plays a key role for its visual detection, it may be adequate to only measure the lightness parameter (L*).