Software-Defined Fog Network Architecture for IoT

Rapid increase in number and diversity of Internet-connected devices raises many challenges for the traditional network architecture, which is not designed to support a high level of scalability, real-time data delivery and mobility. To address these issues, in this paper we present a new model of Internet of Things architecture which combines benefits of two emerging technologies: software-defined networking and Fog computing. Software-defined networking implies a logically centralized network control plane, which allows implementation of sophisticated mechanisms for traffic control and resource management. On the other hand, Fog computing enables some data to be analysed and managed at the network edge, thus providing support for applications that require very low and predictable latency. In the paper, we give detailed insight into the system structure and functionality of its main components. We also discuss the benefits of the proposed architecture and its potential services.     

Hot-cracking of high-alloyed steels evaluated by wedge rolling test

We present a new methodology of determination of hot-cracking of metallic materials, which is based on laboratory application of the wedge rolling test and computer processing of the results obtained. The experiment was made with selected new types of high-alloyed free-cutting (ferritic and austenitic) steels. The initial specimens underwent an additional modification enabling easier development of cracks which consisted in milling out of the defined V-shaped notches on a side wall of a specimen. After taking specimens from the rolled material, we performed the metallographic analysis of microstructures by means of optical microscopy as well as a SEM analysis of the cracks. The resulting microstructure in the propagating crack vicinity was markedly influenced by this fracture. In the crack vicinity, a noticeable refinement of grains was observed due to the stress-induced recrystallization and occurrence of deformation zones that were pronounced by the rolled-out and stretched sulphides. As a rule, fractures were created by the ductile failure with visible pits, caused by tearing of sulphides from the material. Susceptibility of the studied steels to hot-cracking was evaluated and compared. __________ Translated from Problemy Prochnosti, No. 1, pp. 60–63, January–February, 2008.     

Intercomparison of a correlated-photon-based method to measure detector quantum efficiency

We report on the absolute calibration of photodetector quantum efficiency by using correlated photon sources, performed independently at two laboratories, the National Institute of Standards and Technology and the Istituto Elettrotecnico Nazionale (IEN). The goal is to use an interlaboratory comparison to demonstrate the inherent absoluteness of the photon correlation technique by showing its independence from the particular experimental setup. We find that detector nonuniformity limited this comparison rather than uncertainty inherent in the method itself. The ultimate goal of these investigations is development of a robust measurement protocol that allows the uncertainties of individual measurements to be determined experimentally and verified operationally. Furthermore, to demonstrate the generality of the procedure, the IEN measurement setup was also used to calibrate a fiber-coupled avalanche photodiode module. Uncertainties are evaluated for the detector both with and without fiber coupling and differences are discussed. The current IEN setup using a thinner and higher transmittance nonlinear crystal for the generation of correlated photons shows a significant improvement in overall accuracy with respect to previously reported results from IEN [Metrologia 32, 501-503 (1996)].     

Ka/Q band GaAs IMPATT amplifier technology

GaAs IMPATT diodes are capable of generating 2 to 3 W simultaneously with 18–22% efficiency in the 33 GHz to 46 GHz frequency band. The design of the amplifier circuits which utilize these devices is discussed. The circuit design is based on a 3-step closed form algorithm. The first step is a passive circuit characterization with an automatic network analyzer. In the second step, a computer is used to generate diode device lines. The third step is load line synthesis for predictable operation. The resulting performance is described. 2 W over a 2GHz bandwidth was achieved simultaneously with a minimum gain of 12 dB.     

Tumour blood flow and partition coefficients: correlation with grade of cerebral gliomas using xenon-enhanced computed tomography

It is possible to underestimate the grade of nonenhancing cerebral tumours on conventional contrast-enhanced MRI or CT. Differentiation of high- and low-grade gliomas by measurement of the brain-blood partition coefficient lambda (T lambda) with Xe-enhanced CT (XeCT) has been reported. We assessed the practical applications of XeCT in suspected low-grade astrocytomas. We examined 15 patients with tumours which showed no contrast enhancement on conventional MRI and CT, using XeCT. Tumour blood flow (TBF) and T lambda were calculated. Fourteen patients underwent surgery, one patient had a biopsy. We recognized three histological groups. While T lambda differed significantly between them, TBF did not. Group 1 contained grade II-III astrocytomas and T lambda was 0.77; group 2 contained grade I-II astrocytomas with T lambda 1.14, and group 3 four oligodendrogliomas in which a T lambda of 1.50 was found.     

IFN-gamma inhibits the production of latent transforming growth factor-beta1 by mouse inflammatory macrophages

Transforming growth factor (TGF)-beta is a multifunctional cytokine, which in mammals exists in three isoforms (TGF-beta1, 2 and 3). It is synthesized by a variety of cells including macrophages, and exerts potent immunoregulatory effects such as the inhibition of Th1 development and the suppression or reversal of IFN-gamma-induced macrophage activation. In this study we analyzed the effect of IFN-gamma on the production of TGF-beta1 by thioglycolate-elicited mouse peritoneal macrophages under serum-free conditions. Untreated macrophages released TGF-beta1 in its latent form, which became detectable in a capture ELISA specific for active TGF-beta1 after acid activation of the culture supernatants. Treatment with IFN-gamma reduced the amount of latent TGF-beta1 in the culture supernatants in a dose-dependent fashion. The effect of IFN-gamma was confirmed by a newly developed Western blot system for the detection of mouse TGF-beta1 protein. IFN-gamma only weakly (16-24 %) reduced the levels TGF-beta1 mRNA at early and late time points of stimulation, and no evidence was obtained that IFN-gamma suppresses the secretion of latent TGF-beta1. Thus, inhibition of TGF-beta1 production by IFN-gamma is most likely due to decreased synthesis and/or stability of the TGF-beta1 protein, and might be important for the generation of fully activated macrophages and a Th1 response.     

Associations between lung function and estimated average exposure to NO2 in eight areas of Switzerland. The SAPALDIA Team. Swiss Study of Air Pollution and Lung Diseases in Adults

Ample experimental evidence indicates that acute beta-amyloid infusion into the nucleus basalis of rats elicits abrupt degeneration of the magnocellular cholinergic neurons projecting to the cerebral cortex. In fact, involvement of a permanent Ca2+ overload, partially via N-methyl-D-aspartate (NMDA) receptors, was proposed as a pivotal mechanism in beta-amyloid-induced neurodegeneration. A definite measure of NMDA receptor-mediated processes and subsequent Ca2+ entry is the induction of Ca2+/calmodulin-activated neuronal nitric oxide synthase (nNOS) in nerve cells. In the present account we therefore assessed activation of nNOS in correlation with cholinergic decline after beta-amyloid(1-42) or beta-amyloid(25-35) infusion into the rat nucleus basalis. The results demonstrate the beta-amyloid conformation-dependent enhancement of cortical nitric oxide synthase (NOS) activity. Furthermore, chronic application of the polyamine site NMDA receptor blocker ifenprodil effectively attenuated beta-amyloid neurotoxicity. We propose that nNOS activation reflects the degree of beta-amyloid-induced excitotoxic injury in a proportional manner. Moreover, Ca2+-mediated processes via NMDA receptors, or direct binding of beta-amyloid to this receptor may be a critical step in the neurotoxic mechanisms in vivo.     

Endometriosis: clinical, histological and morphometric findings before and after Gn-RH agonist therapy

After bioptical diagnosis of endometriosis, 81 patients were treated with GnRH-agonists buserelin or leuprolide for six months. Biopsies before and after treatment were used to test a semiquantitative score-system, regarding atrophy of glands and stroma cells. Furthermore glandular diameter, circumference and area of nuclei were examined morphometrically using a microscopic semiautomatical measuring system. Morphometrical and histological alterations during therapy were evaluated. Additionally, data suitable for predicting a possible therapeutic success were described. After therapy 40 patients still showed endometriotic implants (partial responder) in contrast to 41 cases without foci (total responder). Therapeutic effect of GnRH-agonists was proved in every respect: clinical complaints decreased markedly during GnRH-agonists therapy. Both buserelin and leuprolide treated groups revealed increase of atrophy and reduction of extension of stroma. Correspondingly morphometrical analysed parameters such as diameter, circumference and area of glands decreased during therapy as well as area of cytoplasm and nuclei. Except the diameter of glands, the leuprolide treated partial responder group (residual foci after GnRH-therapy) revealed a stronger therapeutic effect than the buserelin treated partial responder group. Obviously this effect seems to be produced by the stronger estradiol suppression of leuprolide. Pretherapeutic comparison of measured values pointed out a minor distinct endometriosis in the total responder group. Success or failure of therapy seems to depend more on the pretherapeutic degree of expression of endometriosis. Obviously the kind of applicated GnRH-agonist plays a minor distinct role. Morphometrical data of endometriotic foci appear to be appropriate to predict a possible therapeutic success of GnRH-agonist therapy. But because of many exceptions only a roughly estimated prediction is possible.     

Effects of morphine, ethylketocyclazocine, and N-allylnormetazocine on classical conditioning of the rabbit nictitating membrane response.

The nictitating membrane response of 120 New Zealand albino rabbits was classically conditioned to tone and light conditioned stimuli (CSs) presented for 800 msec before delivery of a 100-msec unconditioned shock stimulus. Both the mu receptor agonist morphine (5 mg/kg) and the kappa receptor agonist ethylketocyclazocine (1 mg/kg) significantly retarded the acquisition of conditioned responses (CRs). The retardant effects of both morphine and ethylketocyclazocine on CR acquisition could still be detected when the Ss were tested 5 days after cessation of drug injections. The sigma receptor agonist N-allylnormetazocine (5 mg/kg) had no effect on acquisition. The retardant effects of morphine and ethylketocyclazocine on acquisition were significantly antagonized by both naloxone (1 mg/kg) and N-allylnormetazocine. It is suggested that mu and possibly kappa receptors are involved in the retardant effects of opiates on CR acquisition. (14 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)