Subclavian venogram as a guide to lead implantation

Melatonin synthesis in retinal photoreceptors is stimulated at night by a circadian oscillator and suppressed acutely by light. To identify photoreceptor mechanisms involved in the acute suppression of melatonin synthesis, an action spectrum was measured for dark-adapted Xenopus laevis eyecups at night. Intensity-response curves at six wavelengths from 400 to 650 nm were parallel, suggesting that a single photopigment predominates in melatonin suppression. Half-saturating intensities at 400, 440, 480, and 533 nm were not significantly different from one another, at 1-2 x 10(8) quanta cm(-2) s(-1). Significantly higher intensities of 580- and 650-nm light were required for melatonin suppression. These results indicate a predominant role for the principal green-absorbing rods in acute regulation of retinal melatonin synthesis in response to light, and argue against an important role for the red-absorbing cones. Higher than expected sensitivity at short wavelengths suggests that photoreceptors sensitive to blue and/or violet light may also contribute to melatonin suppression.     

The questionable promise of social media for education: connective learning and the commercial imperative

Facebook and other social media have been hailed as delivering the promise of new, socially engaged educational experiences for students in undergraduate, self‐directed, and other educational sectors. A theoretical and historical analysis of these media in the light of earlier media transformations, however, helps to situate and qualify this promise. Specifically, the analysis of dominant social media presented here questions whether social media platforms satisfy a crucial component of learning – fostering the capacity for debate and disagreement. By using the analytical frame of media theorist Raymond Williams, with its emphasis on the influence of advertising in the content and form of television, we weigh the conditions of dominant social networking sites as constraints for debate and therefore learning. Accordingly, we propose an update to Williams' erudite work that is in keeping with our findings. Williams' critique focuses on the structural characteristics of sequence, rhythm, and flow of television as a cultural form. Our critique proposes the terms information design, architecture, and above all algorithm, as structural characteristics that similarly apply to the related but contemporary cultural form of social networking services. Illustrating the ongoing salience of media theory and history for research in e‐learning, the article updates Williams' work while leveraging it in a critical discussion of the suitability of commercial social media for education.     

A socio-technical approach to post-occupancy evaluation: interactive adaptability in domestic retrofit

Understanding the process of domestic retrofit is important for learning and innovation. This is particularly the case for low carbon retrofits such as those undertaken under the UK's Retrofit for the Future (RftF) programme, with its aim to achieve an overall 80% carbon reduction by 2050. Current post-occupancy evaluation (POE) research has both theoretical and methodological limitations with implications for technical and behavioural research in the built environment. Drawing on relevant ideas and concepts from social practice theory and science and technology studies, principally prefiguration (constraints/enablement), black-boxing, heating and cooling practices, this paper demonstrates how the relationship between buildings and people could be reconceptualized as mutually constitutive and co-evolving through a process of ‘interactive adaptation’. The concept of ‘interactive adaptation’ is explored through a novel approach to integrating physical and social data collected from a sample of dwellings selected from the RftF programme. Analysis yields insights into the influences and pathways of interactive adaptation resulting from retrofit technology and practices. The implications of these insights for policy-makers, the research community and practitioners are discussed: end-use energy demand policy needs to be informed by a socio-technical approach.     

Detection of Axial Cracks in Pipes Using Focused Guided Waves

The implementation of synthetic guided wave focusing to locate axially aligned defects in pipes has been investigated. Results from both finite element computer models and experiments on real pipes are presented and the data show good agreement. Focusing is necessary to improve the reflection coefficient from axially aligned defects, as the signals are very weak. The Common Source Method (CSM) of synthetic focusing has been applied which makes it possible to apply focusing via post processing to previously collected data. The dependence of reflection coefficient on crack length was measured for both through thickness and part depth axially aligned defects, at a range of frequencies, using the torsional guided wave family. The results show that the reflection coefficient is approximately doubled when focusing is employed, compared to the sensitivity for unfocused fundamental torsional waves. However the sensitivity is still very low, so in practise this approach could only be used to find severe defects.     

Digital business reporting standards: mapping the battle in France

Government agencies use information technology extensively to collect business data for regulatory purposes. Data communication standards form part of the infrastructure with which businesses must conform to survive. We examine the development of, and emerging competition between, two open business reporting data standards adopted by government bodies in France; Electronic Data Interchange for Administration, Commerce and Transport (EDIFACT) (incumbent) and eXtensible Business Reporting Language (XBRL) (challenger). The research explores whether an incumbent may be displaced in a setting in which the contest is unresolved. Latour's translation map is applied to trace the enrollments and detours in the battle. We find that regulators play an important role as allies in the development of the standards. The antecedent networks in which the standards are located embed strong beliefs that become barriers to collaboration and fuel the battle. One of the key differentiating attitudes is whether speed is more important than legitimacy. The failure of collaboration encourages competition. The newness of XBRL's technology just as regulators need to respond to an economic crisis and its adoption by French regulators not using EDIFACT create an opportunity for the challenger to make significant network gains over the longer term. ANT also highlights the importance of the preservation of key components of EDIFACT in ebXML.     

Uptake of energy efficiency interventions in English dwellings

Little detailed evidence has previously been available regarding the uptake rate or prevalence of energy efficiency interventions among specific household groups. This study uses the Home Energy Efficiency Database (HEED) to investigate both the combination of measures that have been installed, and in which dwellings, according to key neighbourhood socio-demographic variables, including income and tenure. Analysis of 2000–07 data indicates that approximately 40% (9.3 million) dwellings in England had approximately 23.7 million efficiency measures installed, with an average of 2.5 measures per dwelling. Building fabric-related measures were the most frequent (e.g. cavity wall insulation, loft insulation and glazing) with an average of 2.1 million installed each year. Dwellings with the highest number of fabric interventions (the top 20%) were more likely to be found in areas with low income, with more owner-occupied dwellings, experiencing lower winter temperatures, having a lower proportion of flats, and having a slightly higher proportion of older adults and children. Energy efficiency installations have tended to occur among specific types of households or parts of the building stock. These findings have implications for the design of future government programmes for targeting energy efficiency measures to specific household groups or dwelling types.     

Defining and meeting the carbon constraints of the 21st century

The magnitude and implications for the construction industry of reductions in carbon dioxide emissions that will ultimately be required globally and in industrialized countries are critically examined. As a result of the problem of climate change, these reductions are found to be in the region of 80–90% by 2050- much larger than those presently under discussion in national and global political fora. The technological feasibility of buildings with low energy requirements and low carbon emissions suggests that existing technology is capable of delivering reductions in this range. Unfortunately, the progress that is being made at the cutting edge is, with very few exceptions, not carried over into building stocks as a whole. Regulatory, fiscal and market-based policy and strategy mechanisms for improving the performance both of new build and the existing stock are critically examined. The achievement of meaningful reductions will require a coordinated and strategic approach, which makes use of the complementarity between these mechanisms. Regulation alone, in the absence of clear and consistent price signals provided through mechanisms such as carbon taxation, is unlikely to deliver the reductions in carbon emissions that will be needed to stabilize the global atmosphere and climate.

L'ampleur et les implications pour l'industrie de construction des réductions des émissions de dioxyde de carbone qui seront généralement exigées en fin de compte font l'objet d'un examen critque dans les pays industrialisés. Suite au problème des changements de climat, on a trouvé qu'en 2050 ces réductions d'émissions devraient se situer dans une zone de 80 à 90 % - c'est à dire, beaucoup plus grands que celle qu'on trouve dans les discussions et symposiums politiques nationaux et mondiaux. La faisabilité technologique de constructions nécessitant peu d'énergie et à faible émission de carbone suggére que la technologie actuelle est capable d'apporter des solutions à ces réductions. Malheureusement, à de rares exceptions prés, les progrés qui sont faits dans ces domaines de pointe ne sont pas appliqués dans leur totalité au secteur du bâtiment. La politique coordinatrice et fiscale, basée sur le marché ainsi que les mécanismes stratégiques visant à améliorer les performances concernant aussi bien les nouvelles constructions que celles existantes, sont examinés d'une façon critique. L'obtention de réductions significatives exigera une approche coordonnée et stratégique mettant en oeuvre ces deux mécanismes complémentaires. La seule réglementation, en l'absence d'arguments de prix clairs et cohérents comme par exemple la taxation sur l'oxyde de carbone, ne va vraisemblablement pas entrâner les réductions d'émissions de gaz carbonique qui seraient nécessaires afin de stabilizer l'atmosphère et le climat au niveau mondial.     

达芬奇效应:简便的数字视频

数字视频将引发人们与电子产品交互方式的变革。实现数字视频不但复杂,而且费时费钱。而这一切难题在达芬奇技术面前全部烟消云散。     

The nucleophilic, phosphine-catalyzed thiol-ene click reaction and convergent star synthesis with RAFT-prepared homopolymers

The synthesis of 3-arm star polymers from reversible addition-fragmentation chain transfer (RAFT)-prepared precursor homopolymers in combination with thiol-ene click chemistry is described. Homopolymers of n-butyl acrylate and N,N-diethylacrylamide were prepared with 1-cyano-1-methylethyl dithiobenzoate and 2,2′-azobis(2-methylpropionitrile) yielding materials with polydispersity indices (M_w/M_n) ≤ 1.18 and controlled molecular weights as determined by a combination of NMR spectroscopy, size exclusion chromatography (SEC), and matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Subsequent one-pot reaction of homopolymer, hexylamine (HexAM), dimethylphenylphosphine (DMPP), and trimethylolpropane triacrylate (TMPTA) results in cleavage of the thiocarbonylthiol end-group (by HexAM) of the homopolymer yielding a macromolecular thiol that undergoes DMPP-initiated thiol-Michael addition to TMPTA yielding 3-arm star polymers. The presence of DMPP is demonstrated to serve an important second role in effectively suppressing the presence of any polymeric disulfide as determined by SEC. Such phosphine-mediated thiol-ene reactions are shown to be extremely rapid, as verified by a combination of FTIR and NMR spectroscopies, with complete consumption of the CC bonds occurring in a matter of min. MALDI-TOF MS and SEC were used to verify the formation of 3-arm stars. A broadening in the molecular weight distribution (M_w/M_n ∼ 1.35) was observed by SEC that was attributed to the presence of residual homopolymer and possibly 2-arm stars formed from trimethylolpropane diacrylate impurity. Interestingly, the MALDI analysis also indicated the presence of 1- and 2-arm species most likely formed from the fragmentation of the parent 3-arm star during analysis. Finally, a control experiment verified that the consumption of CC bonds does not occur via a radical pathway.     

REVLD: A coarse-grained model for polymers

A new model for polymers is presented. REVLD (Rigid, Excluded Volume, Langevin Dynamics) is similar to the coarse-grained, bead spring model for linear chains except that the inter-bead distance is rigidly constrained instead of using an inter-bead potential to encapsulate the connectivity. Static and dynamic results support that REVLD accurately reproduces the single-chain behavior of real polymers known from experiment, theory, and published data from existing models. Additionally, a time step can be used that is at least comparable to simulations using a FENE potential without introducing any computational overhead for accessing longer time scale modes. REVLD, and more simply the idea of using constraints in Cartesian coordinates for large simulations, was made computationally viable through the recent development of the algorithm MILC SHAKE. We expect it to improve established techniques and aid in the development of new models of import to large scale simulations that were not practicable before.