Run-to-run control of blood glucose concentrations for people with Type 1 diabetes mellitus

Run-to-run control has been applied to several traditional batch processes in the chemical industry. The 24-h cycle of eating meals, measuring blood glucose concentrations, and delivering the correct insulin bolus, with the goal of achieving the optimal blood glucose profile, can be viewed in the same spirit as traditional batch processes such as emulsion polymerization. In this paper, we aim to exploit the "repetitive" nature of the insulin therapy of people with Type 1 diabetes. A run-to-run algorithm is used on a virtual diabetic patient model to control blood glucose concentrations. The insulin input is parameterized into the timing and amount of the dose while the glucose output is parameterized into the maximum and minimum glucose concentrations. Robustness of the algorithm to variations in the meal amount, meal timing, and insulin sensitivity parameter is addressed. In general, the algorithm is able to converge when the meal timing is varied within +/- 40 min. If the meal size is underestimated by approximately 10 grams (g), the algorithm is able to converge within a reasonable time frame for breakfast, lunch, and dinner. If the meal size is overestimated by 20-25 g, the algorithm is able to converge. When random variations in the meal timing and the meal amount are introduced, the variation on the output variables, Gmax and Gmin, scales according to the amount of variation allowed. Along with this, the insulin sensitivity of the virtual patient model is varied. The algorithm is robust for differences in insulin sensitivity less than +/- 50% of the nominal value.     

A novel deposit/spin waveguide interconnection (DSWI) for semiconductor integrated optics

We propose an efficient and simple optical interconnection between active semiconductor components by deposition and spin coating. Details of the waveguide design, the fabrication technique, and a promising material combination are given. Experimental results with an integrated laser-polyimide/SiOx(x sim 2) waveguide combination demonstrate low-threshold (2.0 kA/cm²) laser operation and a low-loss waveguide interconnection (81 percent coupling efficiency) on a GaInAsP/InP chip.     

Novel deposit/spin waveguide interconnection (DSWI) technique for semiconductor integrated optics

We propose an efficient and simple optical interconnection between active semiconductor components by deposition and spin coating. The demonstration shows a low-threshold (2.0 kA/cm2) and high-coupling (81%) operation of a laser-polyimide/SiO2 slab waveguide integrated on a GaInAsP/InP chip.     

'Polymorph Method' Determination of Monoclinic Zirconia in Partially Stabilized Zirconia Ceramics

The polymorph method, which provides phase analysis from a small number of integrated intensities in a powder diffraction scan, is adapted for the determination of monoclinic zirconia in a mixture with cubic, tetragonal. and orthorhombic zirconias and the γ-phase (Mg₂Zr₅O₁₂). Such a mixture is representative of Mg-PSZ after subeutectoid aging. The quantitative determination of the monoclinic depends in principle on a knowledge of the relative amounts of the other phases present in the mixture. It is demonstrated, however, that without this knowledge, even in complex mixtures, the traditional polymorph method analysis gives an acceptable estimate of the monoclinic fraction in the sample.     

Interlevel dielectric via etch process monitoring by atomic forcemicroscopy

The use of AFM for in-line monitoring of an interlevel dielectric via plasma etching step is reported. By comparing etch depths, to via types contacting both Au- and W-based metals, the AFM can non-destructively determine whether micrometre-sized vias have been cleared. Owing to the etch selectivity of the SF₆/O₂ plasma, the Au-based ohmic metal acts as an etch stop whereas the W-based refractory gate contact continues to etch     

Use of three-dimensional Gaussian interpolation in the projector/backprojector pair of iterative reconstruction for compensation of known rigid-body motion in SPECT

Due to the extended imaging times employed in single photon emission computed tomography (SPECT) and positron emission tomography (PET), patient motion during imaging is a common clinical occurrence. The fast and accurate correction of the three-dimensional (3-D) translational and rotational patient motion in iterative reconstruction is thus necessary to address this important cause of artifacts. We propose a method of incorporating 3-D Gaussian interpolation in the projector/backprojector pair to facilitate compensation for rigid-body motion in addition to attenuation and distance-dependent blurring. The method works as the interpolation step for moving the current emission voxel estimates and attenuation maps in the global coordinate system to the new patient location in the rotating coordinate system when calculating the expected projection. It also is employed for moving back the backprojection of the ratio of the measured projection to the expected projection and backprojection of the unit value (sensitivity factor) to the original location. MCAT simulations with known six-degree-of-freedom (6DOF) motion were employed to evaluate the accuracy of our method of motion compensation. We also tested the method with acquisitions of the data spectrum anthropomorphic phantom where motion during SPECT acquisition was measured using the Polaris IR motion tracking system. No motion artifacts were seen on the reconstructions with the motion compensation.     

Quantum mechanical aspects of transport in nanoelectronics

The authors discuss some of the effects quantum mechanics has on the performance of nanometer-scale devices. At low temperature, the confinement and the coherence of the electronic motion on the scale of the electron wavelength give rise to gross deviations from classical charge transport that describes the resistance found in large conventional devices. The authors examine three examples of the quantum mechanical nature of the resistance of a split-gate MODFET, that are not accounted for in conventional classical models of a FET, and yet may influence device speed, noise performance and device isolation. The authors consider the temperature and electric field ranges where quantum mechanical effects are manifested in the charge transport, and speculate about the conditions in which parasitic quantum mechanical effects might be found in a conventional device     

Soft-bit decoding of regular low-density parity-check codes

A novel representation, using soft-bit messages, of the belief propagation (BP) decoding algorithm for low-density parity-check codes is derived as an alternative to the log-likelihood-ratio (LLR)-based BP and min-sum decoding algorithms. A simple approximation is also presented. Simulation results demonstrate the functionality of the soft-bit decoding algorithm. Floating-point soft-bit and LLR BP decoding show equivalent performance; the approximation incurs 0.5-dB loss, comparable to min-sum performance loss over BP. Fixed-point results show similar performance to LLR BP decoding; the approximation converges to floating-point results with one less bit of precision.