全文获取类型
收费全文 | 2442篇 |
免费 | 2篇 |
专业分类
电工技术 | 1篇 |
综合类 | 2篇 |
化学工业 | 6篇 |
机械仪表 | 3篇 |
轻工业 | 1篇 |
石油天然气 | 1篇 |
一般工业技术 | 3篇 |
冶金工业 | 2422篇 |
原子能技术 | 2篇 |
自动化技术 | 3篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 1篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2016年 | 1篇 |
2012年 | 1篇 |
2011年 | 1篇 |
2009年 | 1篇 |
2007年 | 1篇 |
2003年 | 3篇 |
2000年 | 1篇 |
1999年 | 70篇 |
1998年 | 742篇 |
1997年 | 415篇 |
1996年 | 298篇 |
1995年 | 148篇 |
1994年 | 128篇 |
1993年 | 143篇 |
1992年 | 13篇 |
1991年 | 24篇 |
1990年 | 25篇 |
1989年 | 21篇 |
1988年 | 22篇 |
1987年 | 21篇 |
1986年 | 16篇 |
1985年 | 13篇 |
1984年 | 3篇 |
1983年 | 7篇 |
1982年 | 14篇 |
1981年 | 14篇 |
1980年 | 23篇 |
1979年 | 3篇 |
1978年 | 9篇 |
1977年 | 61篇 |
1976年 | 179篇 |
1975年 | 4篇 |
1973年 | 2篇 |
1965年 | 1篇 |
1964年 | 3篇 |
1963年 | 1篇 |
1960年 | 1篇 |
1955年 | 3篇 |
1929年 | 1篇 |
排序方式: 共有2444条查询结果,搜索用时 15 毫秒
131.
R Hajdu R Thompson JG Sundelof BA Pelak FA Bouffard JF Dropinski H Kropp 《Canadian Metallurgical Quarterly》1997,41(11):2339-2344
MK-0991 (L-743,872) is a potent antifungal agent featuring long half-life pharmacokinetics. The pharmacokinetics of MK-0991 administered intravenously to mice, rats, rhesus monkeys, and chimpanzees is presented. Unique to MK-0991 is its consistent cross-species performance. The range of values for the pharmacokinetic parameters were as follows: clearance, 0.26 to 0.51 ml/min/kg; half-life, 5.2 to 7.6 h; and distributive volume, 0.11 to 0.27 liters/kg. The level of protein binding of MK-0991 was determined to be 96% in mouse and human serum. The compound exhibited high affinities for human serum albumin and at least two lipid components. The rationale for the selection of MK-0991 as a drug development candidate was based on its two- to threefold superior pharmacokinetic performance in chimpanzees over the performance of an otherwise equivalent analog, L-733,560. Once-daily dosing for MK-0991 is indicated by a graphical comparison of levels in the circulations of chimpanzees and mice. In a study of the pharmacokinetics of MK-0991 in mouse tissue, the organs were assayed following intraperitoneal administration. The area under the concentration-versus-time curves (AUC) segregated the tissues into three exposure categories relative to plasma. The tissues with greater exposure than that for plasma were liver (16 times), kidney (3 times), and large intestine (2 times). The exposure for small intestine, lung, and spleen were equivalent to that for plasma. Organs with lower levels of exposure were the heart (0.3 times that for plasma), thigh (0.2 times), and brain (0.06 times). Kinetically, drug was cleared more slowly from all tissues than from plasma, indicating that terminal-phase equilibrium had not been achieved by 24 h. Thus, some measure of accumulation is predicted for all tissues. Single daily doses of MK-0991 should provide adequate systemic levels of fungicidal activity as a result of its long half-life pharmacokinetics, wide distribution, and slowly accumulating concentrations in tissue. 相似文献
132.
133.
134.
135.
DW Hunt H Jiang DJ Granville AH Chan S Leong JG Levy 《Canadian Metallurgical Quarterly》1999,41(1):31-44
Silencing of the cryptic mating-type loci HMR and HML requires the recognition of DNA sequence elements called silencers by the Sir1p, one of four proteins dedicated to the assembly of silenced chromatin in Saccharomyces cerevisiae. The Sir1p is thought to recognize silencers indirectly through interactions with proteins that bind the silencer DNA directly, such as the origin recognition complex (ORC). Eight recessive alleles of SIR1 were discovered that encode mutant Sir1 proteins specifically defective in their ability to recognize the HMR-E silencer. The eight missense mutations all map within a 17-amino-acid segment of Sir1p, and this segment was also required for Sir1p's interaction with Orc1p. The mutant Sir1 proteins could function in silencing if tethered to a silencer directly through a heterologous DNA-binding domain. Thus the amino acids identified are required for Sir1 protein's recognition of the HMR-E silencer and interaction with Orc1p, but not for its ability to function in silencing per se. The approach used to find these mutations may be applicable to defining interaction surfaces on proteins involved in other processes that require the assembly of macromolecular complexes. 相似文献
136.
Three new triterpene lactones, lancilactones A (1), B (2), and C (3), together with the known kadsulactone A (4), were isolated from the stems and roots of Kadsura lancilimba. Their structures and stereochemistries were determined primarily from mass and NMR spectral data. Compound 3 inhibited HIV replication with an EC50 value of 1.4 microg/mL and a therapeutic index of greater than 71.4. 相似文献
137.
A study was made of the infectivity of Hypoderaeum conoideum miracidia to a range of laboratory-reared specimens of freshwater snail species (Lymnaea peregra, L. corvus, Physella acuta, and Gyraulus chinensis) that coexist with the parasite in the same natural habitat. L. peregra and L. corvus were found to be equally susceptible to the parasite when specimens of each snail species were singly exposed to miracidia. However, when miracidia could choose either lymnaeid species, they showed a high degree of specificity toward L. peregra. The results obtained suggest that H. conoideum miracidia are capable of distinguishing among these lymnaeids in their orientation to the host. This indicates that miracidia might achieve specificity before actually contacting the snail host and suggests that during the host-snail orientation process they respond to signals different from those generated upon snail contact and invasion. The specificity toward L. peregra observed in H. conoideum miracidia seems to indicate adaptation to the snail community in their natural habitat, resulting in enhancement of their transmission. 相似文献
138.
R Halse JJ Rochford JG McCormack JR Vandenheede BA Hemmings SJ Yeaman 《Canadian Metallurgical Quarterly》1999,274(2):776-780
The regulation of glycogen synthesis and associated enzymes was studied in human myoblasts and myotubes maintained in culture. Both epidermal growth factor (EGF) and insulin stimulated glycogen synthesis approximately 2-fold, this stimulation being accompanied by a rapid and stable activation of the controlling enzyme glycogen synthase (GS). EGF also caused inhibition of glycogen synthase kinase 3 (GSK-3) and activation of the alpha isoform of protein kinase B (PKB) with the time-course and magnitude of its effects being similar to those induced by insulin. An inhibitor of the mitogen-activated protein (MAP) kinase pathway did not prevent stimulation of GS by EGF, suggesting that this pathway is not essential for the effect. A partial decrease in the fold activation of GS was, however, observed when p70(S6k) activation was blocked with rapamycin, suggesting a contribution of this pathway to the control of GS by either hormone. Wortmannin, a selective inhibitor of phosphatidylinositol 3'-kinase (PI-3 kinase) completely blocked the effects of both EGF and insulin in these cells. These results demonstrate that EGF, like insulin, activates glycogen synthesis in muscle, acting principally via the PKB/GSK-3 pathway but with a contribution from a rapamycin-sensitive component that lies downstream of PI-3 kinase. 相似文献
139.
140.