Immunogestosis: a new etiologic concept of "essential" EPH gestosis, with special consideration of the primigravid patient; preliminary report of a clinical study

Evidence for immunologic processes taking part in the pathogenesis of what until now has been called the "essential" form of EPH gestosis is cited. The name of immunogestosis (IG) is introduced. The data of this preliminary study suggest that regular "inoculation" of the female genital tract with allogeneic spermatozoal histocompatibility antigens reduces the incidence of IG. Information about preconceptional sexual habits and contraceptive measures was obtained from 83 selected primigravid patients. Twenty-eight women had mild to moderate IG (Group B);55 did not (Group A). Women in Group B had had less contact with spermatozoa of partners than did women in Group A. Oral contraceptive consumption was less in Group B than in Group A. Women in Group B were younger than women in Group A. All these differences were statistically significant. A new immunoetiologic hypothesis referring to IG, as well as the theoretic and clinical implications arising from it, are discussed. This hypothesis is based on the assumption that spermatozoal histocompatibility antigens can either induce immunologic tolerance or be responsible for the phenomenon of immunologic enhancement in the maternal immunosystem. As the fetus inherits paternal histocompatibility antigens, it is concluded that pre-existing tolerance (or enhancement) exerts an IG-preventive function in a subsequent pregnancy.     

Neural basis for the genesis and control of digitalis arrhythmias

The author discussed the increase in the frequency of traumatic paralyses of the ocular muscles, and reported 6 cases of inferior oblique muscle paresis caused by local blunt or sharp traumas (haematoma, contusion, rupture, incarceration) and one case of traumatic Brownian pseudo-paralysis. The localisation of the injuries in 3 cases was on the inferior temporal part and in the other 3 cases on the superior part of the bulbar conjunctiva. Atypical horizontal deviation and characteristic vertical deviation, torsion and torticollis were observed in the majority of cases. One patient recovered spontaneously. 3 patients became asymptomatic after correction by prisms and one after recession of contralateral superior rectus muscle. The symptoms remained unchanged in the case of a "blow out" fracture (in spite of operation) and a Brown's syndrome (without treatment).     

Selective isolation of reversible cold sensitive variants from Chinese hamster ovary cell cultures

The fine structure and cellular associations of the large pigment cells (LPC's) of the compound eye of the house fly were studied with high voltage and conventional electron microscopy. Depending on the sector of the compound eye, the facets are either rectangular or hexagonal. The underside of each facet has indentations exactly aligned with those on top into which inserts an angulated sleeve of LPC's. Under the rectangular lens facet 6 or 8 small compact (in cross section) LPC's join four elongate LPC's. Clusters of compact cells alternate in this ring with elongate ones. Compact cells compress together and become quadrangular (in cross section) several microns below their insertion into the lens and form "building block" corners while elongate cells form "side rails" for the rectangular type of distal pseudocone enclosure. Beneath hexagonal facets all LPC's are rather elongate with out corner cells. In both facet types LPC's enclose the pseudocone for a longitudinal distance of 4 mum and then are displaced as bordering cells by a sleeve of two corneal pigment cells (CPC's), each of which encloses half of the proximal pseudocone. For the following 6 mum of longitudinal distance these concentric sleeves of CPC's and LPC's form a double layer around the pseudocone. At about 10 mum below lens base the two sleeves separate; LPC's become attenuated and extend cable-like to the basement membrane and CPC's enclose the proximal pseudocone, Semper cells and distal retinula. The junction between lens and LPC's has critical structural value in that (1) this is the sole anchorage to the lens by the lengthy remainder of the ommatidium, and (2) LPC's enclose the semiliquid pseudocone in the most distal portion of the pseudocone. In addition to vertical support, the LPC's send out numerous lateral processes that make structural contact among themselves, with the corneal pigment cells and the photoreceptor cells. The structural features of this array are discussed relative to possible physiological roles.     

Search for high-performance probe-fed stacked patches using optimization

High-performance circular probe-fed stacked patch antenna designs are explored through the use of numerical optimization. New trends are sought to aid understanding and to suggest novel solutions. We describe the optimization technique, present a new design trend relating efficiency and bandwidth to the choice of substrate dielectric, and propose and demonstrate a novel, optimized antenna achieving 33% bandwidth whilst maintaining greater than 80% surface wave efficiency.     

NMR investigation of experimental chemical induced brain tumors in rats, potential of a superparamagnetic contrast agent (MD3) to improve diagnosis

The different steps of development of chemically induced brain tumors were investigated in rats by MRI using a superparamagnetic contrast agent, magnetite-dextran nanoparticles (MD3). Sprague-Dawley strain pregnant female rats were injected intravenously with ethynitrosourea solution at the end of pregnancy. Offspring whelped by the inoculated mother were followed. MRI examinations were performed at 0.5 T. MD3 nanoparticles were injected intravenously at a dose of 5 mg Fe kg^-1 body weight 30 min before rat sacrifice. After sacrifice, histological slices were stained with hematoxylin-eosin. Relaxation times were measured at 40 MHz and 37°. MD3 nanoparticles act differently according to the step of the tumor development. Before tumor appearance, at a step characterized by the presence of abnormal cell clusters, relaxation time T2 increased significantly. The T2-weighted image showed a small increase in signal intensity in the lesion. Image contrast was improved by MD3 nanoparticles injection because of the decrease in healthy tissue signal intensity. The Tl-weighted image did not provide any additional information. In presence of a minute tumor, relaxation times decreased in tumor but increased in surrounding tissue. The Tl-weighted image showed a hypersignal on the border of an hyposignal. T2-weighted image showed a hypersignal in the same area. Signal intensity was not modified after MD3 nanoparticles injection. When new vascular capillaries developed in the tumor, MD3 nanoparticles cross into the cerebral parenchyma. Transmission electron microscopy showed magnetite crystals in this specific area on cytoplasm vesicles of glial cells and in tumor-specific membrane arrangements. On T2-weighted image, the hypersignal consisted of a well defined part and a second more fuzzy part, its signal being extinguished after MD3 nanoparticles injection. Necrotic areas and edema can be discriminated. The use of such a superparamagnetic contrast agent would be helpful in early detection of tumor development and in improving distinction of tumor mass from its vascular environment in patients. © 1998 Elsevier Science B.V. All rights reserved.     

Analysis of Circular Cavity With Cylindrical Objects

This paper presents the analysis of electromagnetic wave scattering by cylindrical objects located arbitrarily in a circular cavity. The exact full-wave theory based on the mode-matching method is applied to analyze the structures. The resonance frequencies of the investigated resonators are accurately determined. The validity and accuracy of the approach are verified by comparing the results with those obtained from alternative numerical methods and the authors' experiment.     

Modern development methods and tools for embedded reconfigurable systems: A survey

Heterogeneous reconfigurable systems provide drastically higher performance and lower power consumption than traditional CPU-centric systems. Moreover, they do it at much lower costs and shorter times to market than non-reconfigurable hardware solutions. They also provide the flexibility that is often required for the engineering of modern robust and adaptive systems. Due to their heterogeneity, flexibility and potential for highly optimized application-specific instantiation, reconfigurable systems are adequate for a very broad class of applications across different industry sectors. What prevents the reconfigurable system paradigm from a broad proliferation is the lack of adequate development methodologies and electronics design tools for this kind of systems. The ideal would be a seamless compilation of a high-level computation process specification into an optimized mixture of machine code executed on traditional CPU-centric processors and on the application-specific decentralized parallel data-flow-dominated reconfigurable processors and hardware accelerators. Although much research and development in this direction was recently performed, the adequate methodologies and tools necessary to implement this compilation process as an effective and efficient hardware/software co-synthesis flow are unfortunately not yet in place. This paper focuses on the recent developments and development trends in the design methods and synthesis tools for reconfigurable systems. Reconfigurable system synthesis performs two basic tasks: system structure construction and application process mapping on the structure. It is thus more complex than standard (multi-)processor-based system synthesis for software-programmable systems that only involves application mapping. The system structure construction may involve the macro-architecture synthesis, the micro-architecture synthesis, and the actual hardware synthesis. Also, the application process mapping can be more complicated and dynamic in reconfigurable systems. This paper reviews the recent methods and tools for the macro- and micro-architecture synthesis, and for the application mapping of reconfigurable systems. It puts much attention to the relevant and currently hot topic of (re-)configurable application-specific instruction set processors (ASIP) synthesis, and specifically, ASIP instruction set extension. It also discusses the methods and tools for reconfigurable systems involving CPU-centric processors collaborating with reconfigurable hardware sub-systems, for which the main problem is to decide which computation processes should be implemented in software and which in hardware, but the hardware/software partitioning has to account for the hardware sharing by different computation processes and for the reconfiguration processes. The reconfigurable system area is a very promising, but quite a new field, with many open research and development topics. The paper reviews some of the future trends in the reconfigurable system development methods and tools. Finally, the discussion of the paper is summarized and concluded.     

Propagation in rectangular waveguides periodically loaded with cylindrical posts

The analysis of propagation in periodically loaded waveguide structures is conducted. The eigenvalue equation is derived to determine the propagation constants of the Floquet modes. Theoretical and experimental investigations of semi-periodic structures and their scattering matrices are performed. The existence of passbands and stopbands, which are characteristic for periodic structures, is shown.     

Acoustic emission for detecting deterioration of capacitors under aging

There is continuous pressure on production cost reduction of foil-based capacitors, widely used in domestic appliance. Therefore, investigation of the deterioration mechanisms within capacitors is important to reduce their production costs at maintained reliability. These mechanisms were observed in two capacitors batches of classes Y2 (27 nF) and X2 (470 nF). An acoustic emission signal was observed when the capacitors were polarized by excessive voltage. This signal is induced by partial discharges that can lead to capacitor destruction. Next, the capacitors were aged at elevated temperature and also in presence of excessive polarization. We conclude that the acoustic emission signal can predict deterioration of dielectric insulation resistance in capacitors of class Y2. The observed destruction of capacitor of class X2 is caused mainly by detachment of the sprayed metalized contacts that is induced by overheating during partial discharges sparking.