Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study

Normal women produce small amounts of active androgens. When androgen levels are elevated, such as for example in the polycystic ovary syndrome, this is followed by the development of male physical characteristics and muscle mass, structure and function as well as android adipose tissue distribution and function. Psychological features and stress reactions also seem similar to those of men. Such women have an increased risk of developing hypertension, non-insulin-dependent diabetes mellitus and cardiovascular disease. Recent data have shown that these physical, and psychological characteristics, as well as risk of ill health, are also found in the population of women selected at random. Women in the lowest quintiles of levels of sex-hormone-binding globulin--an indicator inversely related to active androgens--are at risk of developing hypertension, non-insulin-dependent diabetes mellitus and cardiovascular mortality. The mechanism probably includes muscular insulin resistance, following a relative androgen excess. It is thus apparent that androgens, even within the highest levels of the nonselected population of women, are powerful predictors of serious disease development. The population at risk might be as large as about 20% of middle-aged women. This is an area of female disease risk which requires more attention in screening and intervention procedures.     

Photocurable shape-memory polyether-polythioether/graphene nanocomposites and the study of their thermal conductivity

Herein a method is described to prepare photocurable thermally-conductive shape memory epoxy/ graphene composites. By photopolymerizing the epoxy resin diglycidyl ether of bisphenol A with an allyl-functionalized ditertiary amine as the curing agent, jointly with a multifunctional thiol, a crosslinked polyether-polythioether co-network was obtained. The presence of a soft domain like the flexible polythioethers enable the co-network to display shape memory properties. By varying the polyether to polythioether ratio it was possible to modulate the shape memory characteristics of the composite. The effect of the concentration of graphene nanoplatelets (GNP) in the composite was also investigated. Shape memory performances revealed excellent values of shape recovery and shape fixity with maximums of 98 and 99% respectively. The temporary- shaped composites with higher concentration of polythioethers and GNP regained their permanent shapes in 2–3 s when heated above the programming temperature. The thermal conductivity in the composites reached 0.39 W/m°K for the composite with 15% w/w of GNP. The presence of the polythioethers in the co-network enhanced the toughness of the composite as revealed by the impact resistance analysis.     

Influence of thin coatings deposited by a dynamic ion mixing technique on the fatigue life of TITANIUM ALLOYS

The technique of dynamic ion mixing involving a physical vapour deposition method and a simultaneous ion implantation has been used in order to improve the fatigue resistance of two titanium alloys. This process allows the deposition of adherent NiTi and SiC amorphous coatings of the order of 1 m thick. Both treated substrates have been tested at room temperature in the low cycle fatigue range, revealing significant fatigue life improvement. NiTi and SiC films modify the surface deformation mechanisms of fatigued materials and largely suppress or delay crack initiation. These effects depend, however, on the nature of the film, the microstructure of the substrate and the stress amplitude applied during the fatigue tests. To explain the fatigue results, the mechanical properties of these thin films have been characterized by different techniques: scratch-tests, micro-Vickers indentations, Young's modulus measurements by a resonant frequency method and fracture stress determination by in situ tensile tests. The results have shown that their mechanical properties are very different to those of the corresponding classically deposited solid materials and are influenced by the film thickness. The results are discussed according to the mechanical properties of the coatings and the substrate deformation and damage modes associated with their microstructure.     

Albumin exchange and polymorphonuclear vascular transit in hyperoxic pulmonary oedema in awake rats

Vascular inflammatory response to hyperoxia (FIO2 greater than 0.98) was studied in awake jugular and carotid catheterized rats. Simultaneous i.v. injection of 125I albumin (125I A), 99mTc polymorphonuclear cells (99mTc PMN) and 51Cr red blood cells (51Cr RBC) allowed to study both the macromolecule exchange through vascular endothelium and the leukocyte uptake by several organs (liver, lungs, spleen) with respect to radiolabelled red blood cells, as an intravascular reference. Rats were exposed to O2 for 24, 38 and 45 h. They were anesthetized and killed by exanguination 15 to 120 min following the tracer injection. After 45 h exposure, the plasmatic 125I A half-life decreased significantly (158 +/- 42 min for the control; 106 +/- 34 min for the exposed animals). The ratio 125I A/51Cr RBC varied significantly in the lung. The iodinated albumin exchange through lung vascular endothelium was altered at the 24th h, with a significant difference reached by the 45th h. At the same time, the pulmonary decreasing curve of 99mTc/51Cr RBC ratio versus time was not not modified. In our experimental conditions, there was no detectable variation in the lung uptake and vascular transit of PMN cells. The discussion of the results must be related with the technics used in the present work when the albumin exchange increased.     

Assessment of the EEG complexity during activations from sleep

The present study quantitatively analyzes the EEG characteristics during activations (Act) that occur during NREM sleep, and constitute elements of sleep microstructure (i.e. the Cyclic Alternating Pattern). The fractal dimension (FD) and the sample entropy (SampEn) measures were used to study the different sleep stages and the Act that build up the sleep structure. Polysomnographic recordings from 10 good sleepers were analyzed. The complexity indexes of the Act were compared with the non-activation (NAct) periods during non-REM sleep. In addition, complexity measures among the different Act subtypes (A1, A2 and A3) were analyzed. A3 presented a quite similar complexity independently of the sleep stage, while A1 and A2 showed higher complexity in light sleep than during deep sleep. The current results suggest that Act present a hierarchic complexity between subtypes A3 (higher), A2 (intermediate) and A1 (lower) in all sleep stages.     

Fatigue life assessment of nodular cast iron containing casting defects

The fatigue behaviour of a nodular cast iron containing casting defects has been investigated in the high-cycle fatigue regime. In this paper, we propose a fatigue life assessment model for flawed materials based on a fracture mechanics approach which takes into account the position and size of the defect, short crack behaviour and the notch effect introduced by the defect. The fatigue behaviour of smooth samples, and long and short crack behaviour have been experimentally determined in order to identify the relevant mechanical parameters; these being introduced into the model. An experimental study has been made both in air and in vacuum in order to account for the position of the defect, noting that internal defects are supposed to be under vacuum conditions. Experimental results, which are based on a two-crack front-marking technique specially developed for this study, show that the propagation of natural cracks is controlled by the effective stress intensity factor in air as well as in vacuum. The K calculation for a short crack in the stress field of a notch is analysed using numerical elastic–plastic results. Comparison between experimental results and the computation of fatigue life for fatigue lives less than 10⁶ cycles shows that the fatigue behaviour of nodular cast iron is controlled by a propagation process. The model proposed is thus relevant for fatigue lives less than 10⁶ cycles so that the defect can be considered as a crack and the initiation stage neglected. Closer to the fatigue limit, this study shows that the initiation stage should be considered in the assessment of fatigue life of nodular cast iron, because a single macroscopic propagation assessment is not enough to describe the whole fatigue life. The defect cannot be considered as a pre-existent crack in the high-cycle fatigue range (>10⁶ cycles), and the initiation stage that contains microcrack propagation around the defect should be evaluated when assessing the high-cycle fatigue life of nodular cast iron.     

Representations by Contact and Intersection of Segments

A necessary and sufficient condition is given for a connected bipartite graph to be the incidence graph of a contact family of segments and points. We deduce that any four-connected three-colorable plane graph is the contact graph of a family of segments and that any four-colored planar graph without an induced C₄ using four colors is the intersection graph of a family of straight line segments.     

Estimating residual variance in random forest regression

Random forest, a data-mining technique which uses multiple classification or regression trees, is a popular algorithm used for prediction. Inference and goodness-of-fit assessment, however, may require an estimator of variability; in many applications the residual variance is of primary interest. This paper proposes two estimators of residual variance for random forest regression that take advantage of byproducts of the algorithm. The first estimator is based on the residual sum of squares from a random forest fit and uses a bootstrap bias correction. The second estimator is a difference-based estimator that uses proximity measures as weights. The estimators are evaluated through Monte Carlo simulations. Applications of the methods to the problem of assessing the relative variability of males and females on cognitive and achievement tests are discussed, and the methods are applied to estimate the residual variance in test scores for male and female students on the mathematics portion of the 2007 Arizona Instrument to Measure Standards.