Imported measles. A potential control problem

From Dec 23, 1978, through Jan 31, 1979, an outbreak of five laboratory-confirmed cases and four clinical cases of measles occurred in a Vietnamese refugee population living in a single housing complex in Albuquerque, NM. The index cases were in two refugee siblings in whom measles was incubating on arrival in the United States. Despite spread through three subsequent generations of disease transmission within the Vietnamese population, there was no additional spread into the general Albuquerque population. Responsible factors included the age distribution of susceptible persons, the social isolation of the refugee population, and the physical structure of the housing complex. There is a need to identify the problem of imported measles in "ethnic islands" in need of vaccination.     

The psychological development of orphanage-reared infants: interventions with outcomes (Tehran)

This paper describes five successive interventions in the rearing of infants at an orphanage in Tehran, with their outcomes. The outcomes were assessed longitudinally. The first of the successive groups, here called "waves", numbered 15. These Ss constitute the controls. The only intervention consisted of examining the infants every other week during the first year and every fourth week thereafter with the ordinal, sensorimotor scales of Uzgiris and Hunt. The audio-visual intervention intended for the second wave of 10 infants was tape-recorded mother talk and music under the control of the infants and mobiles that the infants could activate. This plan was never adequately implemented because of inadequate supervision. The third wave of 10 infants got extra untutored human care. The fourth wave of 20 infants got the kind of audio-visual intervention originally intended for the second wave plus access to responsive inanimate materials. For the fifth wave, numbering 11, the infant-caretaker ratio was reduced to two or three to one and the caretakers were taught the Badger program supplemented with procedures to foster vocal imitation and semantic mastery of body parts, clothing, toys, and other objects and events regularly encountered. The results show that each successive wave, excepting the second, achieved the top steps of nearly all seven of the ordinal scales at mean ages younger than the preceding wave, and the fifth wave surpassed even home-reared American children from predominantly professional families in achieving the top steps on five of the seven scales. The findings show that infants need not advance along all branches simultaneously and that the kinds of experience encountered determine the branch along which advancement occurs. A number of theoretical implications are examined. Especially important is the idea that a dependable educational psychology for infancy and early childhood calls for much more knowledge than we now have of the kinds of experience that advance development along each of the various branches.     

Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells

Vascular endothelial growth factor (VEGF) is the pivotal angiogenic growth factor activating endothelial cells to migrate, proliferate, and form capillary tubes. For an ordered endothelial cell migration, tissue invasion, and degradation of the extracellular matrix, proteolytic machinery is indispensable. Such machinery, suitable for localized proteolysis, is provided by the prourokinase-urokinase-plasmin system. Prourokinase (pro-uPA), the initial component of this system, is, however, synthesized in its inactive precursor form and as such bound to its cellular receptor uPAR. Here we identify a mechanism via which VEGF(165) interacting with its receptor VEGFR-2 rapidly induces prourokinase activation that is dependent on a change in integrin affinity, activation of matrix metalloproteinase 2 (MMP-2), and pro-uPA being bound to its surface receptor uPAR. This VEGF-induced pro-uPA activation on endothelial cells is responsible for VEGF-dependent local fibrinolytic activity and might be one of the initial steps in the angiogenic process.     

Impact wear of a tool steel

Results from wear studies in repetitive impact sliding are described in this paper. The material pair studied consisted of steel CPM-10V (specimen) (where CPM denotes crucible particle metallurgy) and 17-4 precipitationhardened (PH) steel (counterface) with transverse sliding velocities of 4 and 8 m s^?1. By means of scanning electron microscopy, energy-dispersive analysis of X-rays and X-ray diffraction methods it is shown that the wear is due to a material transport of the counterface 17-4 PH steel to the CPM-10V surface. In the wear process, a change in microhardness of the counterface substrate is apparent, and X-ray diffraction of debris confirms the presence of transformed metal. These products include γ-Fe together with trace amounts of α-Fe₂O₃; however, virtually no carbide from the CPM-10V steel was detected.     

A cytosolic activity distinct from crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells

The leucine-rich nuclear export signal (NES) is used by a variety of proteins to facilitate their delivery from the nucleus to the cytoplasm. One of the best-studied examples, protein kinase inhibitor (PKI), binds to the catalytic subunit of protein kinase A in the nucleus and mediates its rapid export to the cytoplasm. We developed a permeabilized cell assay that reconstitutes nuclear export mediated by PKI, and we used it to characterize the cytosolic factors required for this process. The two-step assay involves an import phase and an export phase, and quantitation is achieved by digital fluorescence microscopy. During the import phase, a fluorescent derivative of streptavidin is imported into the nuclei of digitonin-permeabilized HeLa cells. During the export phase, biotinylated PKI diffuses into the nucleus, binds to fluorescent streptavidin, and mediates export of the complex to the cytoplasm. Nuclear export of the PKI complex is cytosol dependent and can be stimulated by addition of the purified NES receptor, Crm1. HeLa cell cytosol treated with N-ethylmaleimide (NEM) or phenyl-Sepharose to inactivate or deplete Crm1, respectively, is still fully active in the PKI export assay. Significantly, the export activity can be depleted from cytosol by preadsorption with a protein conjugate that contains a functional NES. These data indicate that cytosol contains an export activity that is distinct from Crm1 and is likely to correspond to an NES receptor.     

Factors facilitating or impeding older adults’ creative contributions in the collaborative design of a novel DTV-based application

This article describes some of the challenges of supporting older adults’ creative input to the design of an (as yet) undefined digital television application. Focusing on commonly used brainstorming and paper prototyping techniques, constructive insights are gathered from users with limited experience of interactive technology. Encouraging older participants to move beyond what they are familiar with, the research reports on how fragmented conceptual knowledge of familiar technologies can either facilitate or impede the creative development of new ideas. This includes bias or contradictory ideas that can emerge in the elicitation process. As reported, other factors, such as the self-perception of inadequate drawing skills, demonstrate further barriers for some older adults to articulate their visions and aspirations for suitably designed technology.     

都市校园方庭

创建于1919年的The New School是一座都市中的大学,现有的8个学院分布在纽约曼哈顿各处,与城市血脉相连、融为一体。2008年建成的Sheila C.Johnson设计中     

Shallow water acoustic networks

Underwater acoustic networks are generally formed by acoustically connected ocean bottom sensor nodes, autonomous underwater vehicles (AUVs), and surface stations that serve as gateways and provide radio communication links to on-shore stations. The quality of service of such networks is limited by the low bandwidth of acoustic transmission channels, high latency resulting from the slow propagation of sound, and elevated noise levels in some environments. The long-term goal in the design of underwater acoustic networks is to provide for a self-configuring network of distributed nodes with network links that automatically adapt to the environment through selection of the optimum system parameters. This article considers several aspects in the design of shallow water acoustic networks that maximize throughput and reliability while minimizing power consumption     

PAM decomposition of M-ary multi-h CPM

It is known that any multilevel continuous phase-modulated (CPM) signal with a single modulation index can be exactly represented by a sum of pulse-amplitude modulated (PAM) waveforms. In this paper, we show how multi-h CPM signals can also be represented in this manner. The decomposition is presented in general terms as a function of the alphabet size, modulation indexes, and phase pulse of the CPM scheme. The number of pulses required to exactly construct the signal is shown to increase over that previously given for single-h schemes; this increase is in proportion to the number of modulation indexes. We propose an approximation which significantly reduces the number of signal pulses and which minimizes the mean-squared error for an arbitrary set of modulation indexes. We show that this approximation can have two objectives: 1) to reduce the number of pulses in the same manner as has been proposed for single-h schemes; and/or 2) to reduce the number of multi-h pulses; we also show the conditions where this latter objective is most practical. We compare this minimum mean-squared error approximation with another method which was recently proposed for CPM. We also give numerical results on detection performance which demonstrate the practicality of the proposed approximation.     

Organizational Media Affordances: Operationalization and Associations with Media Use

The concept of affordances has been increasingly applied to the study of information and communication technologies (ICTs) in organizational contexts. However, almost no research operationalizes affordances, limiting comparisons and programmatic research. This article briefly reviews conceptualizations and possibilities of affordances in general and for media, then introduces the concept of organizational media affordances as organizational resources. Analysis of survey data from a large Nordic media organization identified six reliable and valid organizational media affordances: pervasiveness, editability, self-presentation, searchability, visibility, and awareness. Eight media scales based on frequency of use of 10 media within each of three organization levels were differentially associated with these affordances. The conceptualization, measurement approach, and results from this study provide the foundation for considerable future organizational communication and ICT research.