Effect of 5-hydroxytryptamine on the peripheral chemoreceptors in the rat

5-Hydroxytryptamine (5-HT), in the doses of 2-5 mug/kg injected into the carotid body area, produced a significant increase in the respiratory rate and carotid sinus nerve activity. Selective ablation of the ipsilateral carotid sinus nerve abolished the respiratory stimulation produced by the drug. On the other hand, the same doses of 5-HT injected into the ascending aorta did not produce stimulation of respiration when the carotid sinus nerves were sectioned. The activity of the aortic nerves did not increase after injecting the drug into the ascending aorta or at the root of the right subclavian artery. These results indicate that 5-HT stimulates the chemoreceptors in the carotid body of the rat. The lack of responses to the injections of the drug in the aortic or subclavian region was due to the absence of chemoreceptors in these regions of the rat.     

A Carrier-Based Unipolar PWM Current Controller That Minimizes the PWM-Cycle Average Current-Error Using Internal Feedback of the PWM Signals

A carrier-based unipolar pulsewidth modulation (PWM) current controller is described using a one-phase PWM rectifier bridge as a test circuit. The controller PWM signal generator uses a sawtooth carrier signal to obtain both synchronized PWM waveforms and a constant switching frequency. A current-error signal and an amplitude modulation depth signal are used to create the input reference signal to the PWM signal generator. The amplitude modulation depth signal is obtained from the PWM-cycle average of the PWM signal generator output signals. This internal feedback is illustrated using a second-order low pass Butterworth filter. With an appropriately designed low-pass filter, the current-error signal is forced to be centered on zero over a PWM cycle. The maximum peak-peak magnitude of the current-error signal is used as a design guideline for deciding an appropriate gain constant in the controller current feedback loop. The low pass filter design is examined to determine a suitable gain and 20-dB attenuation frequency to minimize the current-error signal. The steady-state and transient operation of the proposed current controller is compared with a proportional-integral controller and an average current-error controller. SPICE simulations and experimental results are used to demonstrate the characteristics of the controller.