全文获取类型
收费全文 | 6654篇 |
免费 | 10篇 |
专业分类
电工技术 | 3篇 |
化学工业 | 63篇 |
金属工艺 | 1篇 |
机械仪表 | 2篇 |
建筑科学 | 7篇 |
能源动力 | 1篇 |
轻工业 | 12篇 |
水利工程 | 4篇 |
石油天然气 | 1篇 |
无线电 | 16篇 |
一般工业技术 | 21篇 |
冶金工业 | 6502篇 |
原子能技术 | 1篇 |
自动化技术 | 30篇 |
出版年
2023年 | 3篇 |
2022年 | 5篇 |
2021年 | 10篇 |
2020年 | 2篇 |
2019年 | 8篇 |
2018年 | 3篇 |
2017年 | 4篇 |
2016年 | 7篇 |
2015年 | 5篇 |
2014年 | 9篇 |
2013年 | 14篇 |
2012年 | 4篇 |
2011年 | 9篇 |
2010年 | 4篇 |
2009年 | 6篇 |
2008年 | 3篇 |
2007年 | 4篇 |
2006年 | 8篇 |
2005年 | 6篇 |
2004年 | 5篇 |
2003年 | 12篇 |
2002年 | 1篇 |
2001年 | 4篇 |
2000年 | 3篇 |
1999年 | 161篇 |
1998年 | 1941篇 |
1997年 | 1135篇 |
1996年 | 762篇 |
1995年 | 387篇 |
1994年 | 347篇 |
1993年 | 389篇 |
1992年 | 49篇 |
1991年 | 102篇 |
1990年 | 106篇 |
1989年 | 90篇 |
1988年 | 102篇 |
1987年 | 89篇 |
1986年 | 77篇 |
1985年 | 59篇 |
1984年 | 2篇 |
1983年 | 13篇 |
1982年 | 32篇 |
1981年 | 48篇 |
1980年 | 58篇 |
1978年 | 26篇 |
1977年 | 182篇 |
1976年 | 351篇 |
1975年 | 10篇 |
1955年 | 4篇 |
1954年 | 3篇 |
排序方式: 共有6664条查询结果,搜索用时 0 毫秒
71.
Dr. Andrea Angeli Prof. Marta Ferraroni Prof. Antonella Capperucci Dr. Damiano Tanini Prof. Gabriele Costantino Prof. Claudiu T. Supuran 《ChemMedChem》2022,17(11):e202200085
A study on the activity of selenocarbamates as a novel chemotype acting as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors is reported. Undergoing CA-mediated hydrolysis, selenocarbamates release selenolates behaving as zinc binding groups and effectively inhibiting CAs. A series of selenocarbamates characterised by high molecular diversity and complexity have been studied against different human CA isoforms such as hCA I, II, IX and XII. Selenocarbamates behave as masked selenols with potential biological applications as prodrugs for CAs inhibition-based strategies. X-ray studies provided insights into the binding mode of this novel class of CA inhibitors. 相似文献
72.
The tackiness of model soft adhesive layers based on styrene‐isoprene‐styrene block copolymers and a tackifying resin were investigated with a flat‐ended cylindrical steel probe. The contact between the probe and the adhesive was maintained for 1 s at a nominal pressure of 1 MPa before being detached at a constant velocity. The effect of resin content, probe velocity during debonding and temperature were systematically investigated. Failure was initiated by two main mechanisms: an interfacial cavitation at low debonding rates, giving relatively low adhesion energies, and a bulk cavitation process at higher debonding rates, which gave much higher adhesion energies. In both cases failure occurred at the end by interfacial detachment of fibrils. The characteristic probe velocity where the transition between these two mechanisms took place was controlled primarily by the linear viscoelastic properties of the adhesives. However, the important quantitative parameters obtained from a tack test, i.e., the maximum debonding stress and the adhesion energy, could not be predicted by the linear viscoelastic properties of these adhesives alone. 相似文献
73.
Niccoletta Barbani Elisabetta Rosellini Marco Donati Paolo Costantino Caterina Cristallini Gianluca Ciardelli 《Polymer International》2017,66(6):900-907
The purpose of this work was the preparation and characterization of polymeric membranes for the selective recognition of saccharides using molecular imprinting technology associated with phase inversion. A system able to bind saccharides with high selectivity is particularly important in the pharmaceutical sector, since some of these compounds are constituents of molecules which can exert serious toxic effects even at very low concentrations. Two polymeric matrices were prepared using poly(ethylene‐co‐vinyl alcohol) copolymers, with an ethylene molar content of 32% and 44%, and were imprinted with two different saccharide molecules: maltose and 2‐keto‐3‐deoxy‐d ‐manno‐octulosonate (KDO). Matrices imprinted against maltose and KDO showed an easy template extraction, high binding capability and satisfactory selectivity, particularly for the matrix with an ethylene molar content of 44%. © 2017 Society of Chemical Industry 相似文献
74.
75.
The antifibrinolytic drug trans-4-(aminomethyl)cyclohexanecarboxylate (tranexamic anions) was intercalated by anion exchange into Mg/Al layered double hydroxide (LDH). The hybrid, of formula [Zn0.65Al0.35(OH)2]Trx0.24(CO3)0.055 × 1.5H2O, was characterized by chemical and thermal analyses and X-ray powder diffraction.Different amounts of the hybrid material were incorporated into poly(ε-caprolactone) by high energy ball milling technique and processed as films. The composite materials were analyzed by X-ray diffractometry, thermogravimetry and FT-IR spectroscopy to clarify the filler-polymer structural organization. An investigation of the mechanical properties of the composite showed an improvement of mechanical parameters, in particular the elastic modulus, when compared to of the pristine polymer. Thus, the inorganic component, even in small quantities, beside acting as a reservoir of active molecular anions, can improve the physical properties.A new method for the quantitative determination of tranexamic anions by infrared spectroscopic analysis was proposed and the release process of the tranexamic anions from the composite into a physiological solution was monitored. The release consisted of two stages: a first stage, very rapid as a burst, in which a small fraction of intercalated drug was released and of a second stage over longer time, much slower than the first.The composites are very promising in the preparation of new hybrid polymeric materials to be used for the molecular delivery of drugs in topical applications, as suture threads or medicate scaffolds. 相似文献
76.
77.
C Reavill JP Hatcher VA Lewis GJ Sanger J Hagan 《Canadian Metallurgical Quarterly》1998,357(2-3):115-120
5-HT4 receptors are concentrated in areas of the brain which are rich in dopamine neuronal markers, which may suggest that they influence motor and reward processes. We tested this hypothesis by examining the effects of a 5-HT4 receptor antagonist, 8-amino-7-chloro-(N-butyl-4-piperidyl)methylbenzo-1,4-dioxan-5-car boxylate hydrochloride (SB-204070-A) on amphetamine- and nicotine-induced locomotor stimulation in intact rats. In rats with unilateral 6-hydroxydopamine-induced lesions of the ascending nigrostriatal dopaminergic projection, SB-204070-A was tested for its effects on amphetamine-induced rotation. SB-204070-A was also tested for its effects on rewarded behaviour maintained by intracranial self-stimulation. SB-204070-A did not alter behaviour under any of these conditions, suggesting a lack of involvement of the 5-HT4 receptor in motor and reward processes. 相似文献
78.
RB Cohen JP Dormans ME Guttenberg JV Hunter 《Canadian Metallurgical Quarterly》1997,(343):249-52, 256-9
79.
G Maya-Nu?ez JC Zenteno A Ulloa-Aguirre S Kofman-Alfaro JP Mendez 《Canadian Metallurgical Quarterly》1998,83(5):1650-1653
Kallmann's syndrome (KS) is defined by the association of hypogonadotropic hypogonadism and anosmia or hyposmia. Segregation analysis in familial cases has demonstrated diverse inheritance patterns, suggesting the existence of several genes regulating GnRH secretion. Genetic defects have been demonstrated in the KAL gene, located on the Xp22.3 region, explaining the X-linked form of the disease. We report molecular findings regarding the KAL gene in 12 unrelated males with X-linked KS. PCR of the 14 exons of the KAL gene was performed on genomic DNA. PCR products of all exons were purified and sequenced. Genetic defects in the KAL gene were found in 7 patients. One exhibits a deletion from exon 3 to exon 5. Six individuals present a previously unidentified missense mutation in exon 11, consisting of a G to A substitution at codon 514 (GAA to AAA). In the remaining 5 individuals, no mutations were observed. We also found three different polymorphic changes. The first one, in exon 2, had not been reported previously. The other two were located at exons 11 and 12. The deletion described, comprises only part (exon 5) of the coding region of the first fibronectin type III-like repeat of the KAL protein. The rest of the deletion comprises part of the conserved cysteine-rich N-terminal region that corresponds to the whey acidic protein motif. The same missense mutation was found in 6 of the 12 patients, indicating the possibility that it derived from a common ancestor or suggesting the presence of a hot spot in this region of the gene. 相似文献
80.
The spindle checkpoint ensures proper chromosome segregation by delaying anaphase until all chromosomes are correctly attached to the mitotic spindle. We investigated the role of the fission yeast bub1 gene in spindle checkpoint function and in unperturbed mitoses. We find that bub1(+) is essential for the fission yeast spindle checkpoint response to spindle damage and to defects in centromere function. Activation of the checkpoint results in the recruitment of Bub1 to centromeres and a delay in the completion of mitosis. We show that Bub1 also has a crucial role in normal, unperturbed mitoses. Loss of bub1 function causes chromosomes to lag on the anaphase spindle and an increased frequency of chromosome loss. Such genomic instability is even more dramatic in Deltabub1 diploids, leading to massive chromosome missegregation events and loss of the diploid state, demonstrating that bub1(+ )function is essential to maintain correct ploidy through mitosis. As in larger eukaryotes, Bub1 is recruited to kinetochores during the early stages of mitosis. However, unlike its vertebrate counterpart, a pool of Bub1 remains centromere-associated at metaphase and even until telophase. We discuss the possibility of a role for the Bub1 kinase after the metaphase-anaphase transition. 相似文献