Therapeutic strategies in acute myocardial infarction. Results of STIM 93 registry

A registry was set up by the national college of cardiologists practicing in general hospitals in February 1993. The data concerned mode of admission, demographic details, initial clinical and haemodynamic evaluation and hospital outcome. Special attention was given to the electrocardiographic changes before and, in patients receiving thrombolytic therapy, after treatment. An analysis of predictive factors for mortality was performed both in the group of patients "revascularised" and in the group treated conventionally. One thousand and twenty three cases from 327 centres were analysed. There were 1292 men and 531 women, with an average age of 67.9 years. The average time interval from onset of symptoms to hospital admission was 5 h 30 min, 56.8% of patients arriving within 6 hours. 36.4% of the population underwent thrombolysis or angioplasty, 75% of patients under 75 years of age admitted before the 5th hours underwent a procedure of myocardial revascularisation. The hospital mortality was 14%, 8.7% in those revascularised and 17% in patients treated conventionally. Factors predictive of mortality were age, female gender, Killip Classes III or IV, systolic blood pressure of less than 100 mmHg, heart rate of more than 100/min and contraindications of thrombolysis. The maximum ST depression, the sum of ST depression, the sum of ST elevation and depression, were also significant predictive factors of a fatal hospital outcome in the whole population group and in patients treated conventionally. In the reperfused group, only the initial sum of ST elevation and depression was predictive of mortality: 120 minutes after the beginning of thrombolysis, the sum of ST elevations and of elevations and depressions was predictive of twice the mortality when the values exceeded 0.6 mv and 1.4 mv respectively.     

Clinical, morphologic and immunophenotypic data based on 10 cases of canine muco-cutaneous epidermotropic T-lymphoma (analogous to Mycosis Funcgo?de). Important of an animal model of spontaneous pathology

Our serie of ten canine cutaneous epitheliotropic T-cell lymphomas (CTCL), is found in old dogs, belonging mainly to the Boxer breed. Site on the mucous membranes (especially buccal), the muco-cutaneous junctions, their clinical expression is polymorphous. Lesions, follow on one after another (erythema, plaques, nodules) and are diversely associated in a given animal, the borders between the different stages often being difficult to establish. Adenopathies noted at the time of the diagnosis or during the course of the condition are accompanied by an involvement of the blood and organs (analogous to Sézary's disease). The progression of the disease can be very rapid in the buccal forms, which are generally aggressive, and in cases of violent, uncontrollable pruritus, which may be disturbing for the owner (with requests for euthanasia). The neoplastic infiltrate is constituted of small lymphocytes with hyperchromatic, convoluted nuclei (incipient stages), then large cells with a "histiocytic" appearance for the nodules. Epitheliotropism, which is maximal for the infiltrated plaque stage, shows up either in the form of a flux of totally epitheliotropic isolated cells (Ketron-Goodman type) or in that of Pautrier abscess-like collections. THe veterinary literature is in agreement that the CTCL cell expresses CD3, but two recent studies are in contradiction as regards its membership of helper or cytotoxic/suppressor populations. For our 10 cases, all the cells of lymphocytic morphology were, without exception, CD3+ and CD45+, irrespective of their situation within the epithelium or the chorion. The CD3+ cells in the epithelium were systematically CD8+, CD4- (confirming P.F. Moore's observations), expressing CD5 in a variable way, and, mostly, the Ki-67 nuclear proliferation Ag. The CD3+ cells of the chorion were exclusively, or mainly, CD8+, and occasionally CD4+. They expressed CD5 in a variable way, and, for a minority, the Ki-67 nuclear proliferation Ag. On the pathogenic level, it may be suggested that a T clone, CD8+, undergoes the "homing" phenomenon within the epithelium, enters the cell cycle, then manifests a tropism towards the chorion, which it infiltrates. Despite some particularities, which may be clinical (serious mucous attacks), cytological (the "histiocytic" appearance of the nodule cells) or immunophenotypic (expression of CD8, similar to what is observed in man in a considerable number of Pagetoid reticulosis), CTCL constitutes an interesting model of spontaneous pathology, and could prove useful in: - identifying various etiological factors (given that the dog, as a close commensal of man, is subject to the same environmental factors).     

An Internet-based negotiation server for e-commerce

This paper describes the design and implementation of a replicable, Internet-based negotiation server for conducting bargaining-type negotiations between enterprises involved in e-commerce and e-business. Enterprises can be buyers and sellers of products/services or participants of a complex supply chain engaged in purchasing, planning, and scheduling. Multiple copies of our server can be installed to complement the services of Web servers. Each enterprise can install or select a trusted negotiation server to represent his/her interests. Web-based GUI tools are used during the build-time registration process to specify the requirements, constraints, and rules that represent negotiation policies and strategies, preference scoring of different data conditions, and aggregation methods for deriving a global cost-benefit score for the item(s) under negotiation. The registration information is used by the negotiation servers to automatically conduct bargaining type negotiations on behalf of their clients. In this paper, we present the architecture of our implementation as well as a framework for automated negotiations, and describe a number of communication primitives which are used in the underlying negotiation protocol. A constraint satisfaction processor (CSP) is used to evaluate a negotiation proposal or counterproposal against the registered requirements and constraints of a client company. In case of a constraint violation, an event is posted to trigger the execution of negotiation strategic rules, which either automatically relax the violated constraint, ask for human intervention, invoke an application, or perform other remedial operations. An Event-Trigger-Rule (ETR) server is used to manage events, triggers, and rules. Negotiation strategic rules can be added or modified at run-time. A cost-benefit analysis component is used to perform quantitative analysis of alternatives. The use of negotiation servers to conduct automated negotiation has been demonstrated in the context of an integrated supply chain scenario. Received: 30 October 2000 / Accepted: 12 January 2001 Published online: 2 August 2001     

Boundary detection in multidimensions

The development of image processing algorithms for time-varying imagery and computerized tomography data calls for generalization of the concepts of adjacency, connectivity, boundary, etc., to three and four-dimensional discrete spaces. This paper defines these basic concepts in unified terminology and presents algorithms for a boundary detection task in multidimensional space. The performance of these algorithms is discussed with respect to theoretical maximum complexity, and is illustrated with simulated computerized tomography data.     

Galectin 1—A Key Player between Tissue Repair and Fibrosis

Galectins are ten family members of carbohydrate-binding proteins with a high affinity for β galactose-containing oligosaccharides. Galectin-1 (Gal-1) is the first protein discovered in the family, expressed in many sites under normal and pathological conditions. In the first part of the review article, we described recent advances in the Gal-1 modulatory role on wound healing, by focusing on the different phases triggered by Gal-1, such as inflammation, proliferation, tissue repair and re-epithelialization. On the contrary, Gal-1 persistent over-expression enhances angiogenesis and extracellular matrix (ECM) production via PI3K/Akt pathway activation and leads to keloid tissue. Therefore, the targeted Gal-1 modulation should be considered a method of choice to treat wound healing and avoid keloid formation. In the second part of the review article, we discuss studies clarifying the role of Gal-1 in the pathogenesis of proliferative diabetic retinopathy, liver, renal, pancreatic and pulmonary fibrosis. This evidence suggests that Gal-1 may become a biomarker for the diagnosis and prognosis of tissue fibrosis and a promising molecular target for the development of new and original therapeutic tools to treat fibrosis in different chronic diseases.     

Linearized microring-loaded Mach-Zehnder modulator with RF gain

A linearized modulator based on the Mach-Zehnder interferometer (MZI) loaded with a second-order allpass microring resonator is proposed and analyzed. The device is shown to exhibit much smaller intermodulation distortion than standard Mach-Zehnder modulators, thus greatly enhancing the device dynamic range. Gain effect associated with the microring resonance results in a modulator transfer function with high slope efficiency and large RF gain. Moreover, combined with the use of a highly electrooptic polymer, the high slope efficiency allows for the possibility of realizing modulators with subvolt drive voltage. The detrimental effect of loss in the microring resonators on device performance is also investigated and a design approach to mitigate its effect is presented. The proposed modulator can be linearized to any arbitrary nth order by loading the MZI with a higher order allpass microring resonator.     

Synthesis of Imidazole‐Based AIEgens with Wide Color Tunability and Exploration of their Biological Applications

Research on aggregation‐induced emission (AIE) has become increasingly popular recently and various AIE luminogens (AIEgens) have been developed based on tetraphenylethene, hexaphenylsilole, distyrylanthracene, tetraphenylpyrazine, etc. However, facile tuning of the AIEgen emissions in a wide range remains challenging. Herein, a novel series of AIEgens is reported, based on imidazole‐cored molecular rotors, with facile synthesis and emission colors covering the whole visible spectrum. Moreover, these imidazole derivatives exhibit biological functions unique among the AIEgens, including mitochondria‐specific imaging and antifungal activity. Benefiting from the easy preparation and the tunable emission, the imidazole derivatives are expected to not only diversify the family of AIEgens but also enrich their biological applications.     

Reconstruction from Sparsely Sampled Data by ART with Interpolated Rays

After a brief discussion of the algebraic reconstruction techniques (ART), we introduce the attenuation problem in positron emission tomography (PET). We anticipate that a generalization of ART, the so-called cyclic subgradient projection (CSP) method, may be useful for solving this problem. This, however, has not been successfully realized, due to the fact that data collected by our proposed stationary PET detector ring are too sparsely sampled. That this is, in fact, a major problem is demonstrated by showing that ordinary ART produces reconstructions with unacceptably strong artifacts even on perfect (no attenuation) data collected according to the PET geometry. We demonstrate that the source of this artifact is the sparse sampling, and we propose the use of interpolated rays to overcome the problem. This approach is successful, as is illustrated by showing reconstructions from sparsely sampled data by ART with interpolated rays.     

Accelerating Machine-Learning Algorithms on FPGAs using Pattern-Based Decomposition

Machine-learning algorithms are employed in a wide variety of applications to extract useful information from data sets, and many are known to suffer from super-linear increases in computational time with increasing data size and number of signals being processed (data dimension). Certain principal machine-learning algorithms are commonly found embedded in larger detection, estimation, or classification operations. Three such principal algorithms are the Parzen window-based, non-parametric estimation of Probability Density Functions (PDFs), K-means clustering and correlation. Because they form an integral part of numerous machine-learning applications, fast and efficient execution of these algorithms is extremely desirable. FPGA-based reconfigurable computing (RC) has been successfully used to accelerate computationally intensive problems in a wide variety of scientific domains to achieve speedup over traditional software implementations. However, this potential benefit is quite often not fully realized because creating efficient FPGA designs is generally carried out in a laborious, case-specific manner requiring a great amount of redundant time and effort. In this paper, an approach using pattern-based decomposition for algorithm acceleration on FPGAs is proposed that offers significant increases in productivity via design reusability. Using this approach, we design, analyze, and implement a multi-dimensional PDF estimation algorithm using Gaussian kernels on FPGAs. First, the algorithm’s amenability to a hardware paradigm and expected speedups are predicted. After implementation, actual speedup and performance metrics are compared to the predictions, showing speedup on the order of 20× over a 3.2 GHz processor. Multi-core architectures are developed to further improve performance by scaling the design. Portability of the hardware design across multiple FPGA platforms is also analyzed. After implementing the PDF algorithm, the value of pattern-based decomposition to support reuse is demonstrated by rapid development of the K-means and correlation algorithms.     

Electronically tunable floating inductance simulator

In this letter, a new floating inductance simulator circuit is presented. The proposed structure consists of only one grounded capacitor without any external resistors and two different active elements. The active elements are dual-output current-controlled current conveyor (DO-CCCII) and operational transconductance amplifier (OTA). The proposed inductance simulator can be tuned electronically by changing the biasing current of the DO-CCCIIs or by changing the current of the OTA. Moreover, the circuit does not require any conditions of component matching. It has a good sensitivity performance with respect to tracking errors. As an application, the proposed inductance simulator is used to construct a fourth-order resistively terminated LC band-pass filter. The theoretical analysis is verified by the SPICE simulation results.