全文获取类型
收费全文 | 6717篇 |
免费 | 76篇 |
国内免费 | 3篇 |
专业分类
电工技术 | 39篇 |
综合类 | 3篇 |
化学工业 | 398篇 |
金属工艺 | 53篇 |
机械仪表 | 47篇 |
建筑科学 | 89篇 |
矿业工程 | 7篇 |
能源动力 | 39篇 |
轻工业 | 326篇 |
水利工程 | 16篇 |
石油天然气 | 6篇 |
无线电 | 201篇 |
一般工业技术 | 367篇 |
冶金工业 | 4784篇 |
原子能技术 | 17篇 |
自动化技术 | 404篇 |
出版年
2022年 | 18篇 |
2021年 | 32篇 |
2020年 | 32篇 |
2019年 | 36篇 |
2018年 | 37篇 |
2017年 | 38篇 |
2016年 | 34篇 |
2015年 | 32篇 |
2014年 | 48篇 |
2013年 | 122篇 |
2012年 | 79篇 |
2011年 | 111篇 |
2010年 | 89篇 |
2009年 | 77篇 |
2008年 | 102篇 |
2007年 | 112篇 |
2006年 | 98篇 |
2005年 | 66篇 |
2004年 | 68篇 |
2003年 | 72篇 |
2002年 | 68篇 |
2001年 | 46篇 |
2000年 | 55篇 |
1999年 | 204篇 |
1998年 | 1442篇 |
1997年 | 812篇 |
1996年 | 520篇 |
1995年 | 285篇 |
1994年 | 246篇 |
1993年 | 316篇 |
1992年 | 61篇 |
1991年 | 76篇 |
1990年 | 75篇 |
1989年 | 97篇 |
1988年 | 89篇 |
1987年 | 77篇 |
1986年 | 62篇 |
1985年 | 74篇 |
1984年 | 26篇 |
1983年 | 38篇 |
1982年 | 56篇 |
1981年 | 51篇 |
1980年 | 56篇 |
1979年 | 27篇 |
1978年 | 30篇 |
1977年 | 120篇 |
1976年 | 241篇 |
1975年 | 32篇 |
1972年 | 12篇 |
1963年 | 13篇 |
排序方式: 共有6796条查询结果,搜索用时 31 毫秒
51.
52.
53.
RJ Bergeron WR Weimar Q Wu Y Feng JS McManis 《Canadian Metallurgical Quarterly》1996,39(26):5257-5266
A series of analogues and homologues of spermine were synthesized, and their impact on MK-801 binding to the N-methyl-D-aspartate (NMDA) receptor was evaluated. These tetraamines encompass both linear and cyclic compounds. The linear molecules include norspermine, N1, N11-diethylnorspermine, N1,N12-bis(2,2,2-trifluoroethyl)spermine, homospermine, and N1,N14-diethylhomospermine. The cyclic tetraamines consist of the piperidine analogues N1,N3-bis(4-piperidinyl)-1,3-diaminopropane, N1,N4-bis(4-piperidinyl)-1,4-diaminobutane, N1,N4-bis(4-piperidinylmethyl)-1,4-diaminobutane, and N1,N4-bis[2-(4-piperidinyl)ethyl]-1,4-diaminobutane and the pyridine analogues N1,N3-bis(4-pyridyl)-1,3-diaminopropane, N1,N4-bis(4-pyridyl)-1,4-diaminobutane, N1,N4-bis(4-pyridylmethyl)-1,4-diaminobutane, and N1,N4-bis[2-(4-pyridyl)-ethyl]-1,4-diaminobutane. This structure-activity set makes it possible to establish the importance of charge, intercharge distance, and terminal nitrogen substitution on polyamine-regulated MK-801 binding in the NMDA channel. Four families of tetraamines are included in this set: norspermines, spermines, homospermines, and tetraazaoctadecanes. Calculations employing a SYBYL modeling program revealed that the distance between terminal nitrogens ranges between 12.62 and 19.61 A. The tetraamines are constructed such that within families cyclics and acyclics have similar lengths but different nitrogen pKa's and thus different protonation, or charge, states at physiological pH. The pKa values for all nitrogens of each molecule and its protonation state at physiological pH are described. The modifications at the terminal nitrogens include introduction of ethyl and beta,beta,beta-trifluoroethyl groups and incorporation into piperidinyl or pyridyl systems. The studies clearly indicate that polyamine length, charge, and terminal nitrogen substitution have a significant effect on how the tetraamine regulates MK-801 binding to the NMDA receptor. Thus a structure-activity basis set on which future design of MK-801 agonists and antagonists can be based is now available. 相似文献
54.
55.
Examines, in the context of cancer illness, S. E. Taylor and J. D. Brown's (see record 1988-16903-001) claim that mental health is to a degree predicated on illusory beliefs about the self, one's control, and the future. The Heroic Model (HM), a stance toward cancer characterized by belief that positive thoughts and feelings, a fighting spirit, and an optimistic outlook will promote cancer remission, is presented as paradigmatic of Taylor and Brown's thesis. Strong and weak formulations of the HM (the former affirming a direct influence of mental states over physical processes, and the latter affirming indirect effects only) are examined with respect to their potential adaptive value as true or false beliefs, with different consequences for well-being. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
56.
JS Lee S Scala Y Matsumoto B Dickstein R Robey Z Zhan G Altenberg SE Bates 《Canadian Metallurgical Quarterly》1997,65(4):513-526
MCF-7 human breast cancer cells selected in Adriamycin in the presence of verapamil developed a multidrug resistant phenotype, which was characterized by as much as 100,000-fold resistance to mitoxantrone, 667-fold resistance to daunorubicin, and 600-fold resistance to doxorubicin. Immunoblot and PCR analyses demonstrated no increase in MDR-1 or MRP expression in resistant cells, relative to parental cells. This phenotype is similar to one previously described in mitoxantrone-selected cells. The cells, designated MCF-7 AdVp, displayed a slower growth rate without alteration in topoisomerase II alpha level or activity. Increased efflux and reduced accumulation of daunomycin and rhodamine were observed when compared to parental cells. Depletion of ATP resulted in complete abrogation of efflux of both daunomycin and rhodamine. No apparent alterations in subcellular daunorubicin distribution were observed by confocal microscopy. No differences were noted in intracellular pH. Molecular cloning studies using DNA differential display identified increased expression of the alpha subunit of the amiloride-sensitive sodium channel in resistant cells. Quantitative PCR studies demonstrated an eightfold overexpression of the alpha subunit of the Na+ channel in the resistant subline. This channel may be linked to the mechanism of drug resistance in the AdVp cells. The results presented here support the hypothesis that a novel energy-dependent protein is responsible for the efflux in the AdVp cells. Further identification awaits molecular cloning studies. 相似文献
57.
58.
We have investigated the effects of the neutral endopeptidase inhibitor, SCH 42354, on the vasoreactivity of atrial natriuretic peptide (ANP) in rat isolated pulmonary resistance vessels (PRV) and isolated perfused lungs (IPL). PRV (n = 37) were mounted onto the jaws of a myograph and precontracted with PGF2alpha (100 mu M). Concentration-responses to ANP (0.17 to 340 nM) were determined before and after the addition of SCH 42354 (10, 30 and 100 nM). Each concentration of SCH 42354 caused a significant increase in potency (- log EC50) of ANP in isolated PRV. Lungs from normoxic rats (n = 13) were isolated and perfused with whole blood. An increase in pulmonary artery pressure was achieved by ventilating with an hypoxic gas mixture and concentration-responses obtained by incremental additions of ANP (40 nM to 12 mu M), before and after the addition of SCH 42354 (100 nM). SCH 42354 significantly increased the potency (- log EC50) of ANP in the rat IPL. ANP is partly metabolized by NEP. That an inhibitor of NEP increased the potency of ANP in isolated pulmonary vessels, and in isolated perfused whole lungs, suggested that SCH 42354 may be having a local action within the pulmonary vasculature. 相似文献
59.
60.