Cardiovascular and biochemical evidence of stress during major surgery associated with different techniques of anaesthesia

The relative merits of a potent narcotic and a spinal analgesic to affect the stress response to a standard operation have been assessed. Forty-five fit patients scheduled for abdominal hysterectomy were allocated at random to three groups, referred to as standard (i.v. anaesthesia alone), spinal (spinal plus i.v. anaesthesia) and fentanyl (fentanyl plus i.v. anaesthesia) groups. In the doses used, fentanyl produced the most effective attenuation of the cardiovascular, hormonal and metabolic responses to stress, but had the disadvantage of prolonged respiratory depression. Spinal anaesthesia gave only a modified blockade of the response to stress and did not obtund the response to intubation.     

Information from social networking sites: Context collapse and ambiguity in the hiring process

Forming impressions of job candidates is a challenging process, one characterized by ambiguity brought about by the uncertainty associated with making decisions and judgments. To reduce ambiguity, hiring professionals have established policies and procedures to facilitate the sourcing and use of information about a candidate. However, recently, a public source of information is increasingly being used—information from social networking sites (SNSs). While conventional wisdom says more information is better and can help make decisions less ambiguous, this relationship may not be as straightforward as expected when facing assessments of candidates. This paper examines two such aspects, information‐task quality and context collapse, and their collective impact on ambiguity when making an assessment of a job candidate. Using data from an online survey‐based experiment, the findings suggest information from SNSs can be useful, yet can create ambiguity for decision makers because of context collapse made possible by SNS technologies.     

Effects of temperature on a.c. magnetostriction in grain-oriented silicon-iron

The a.c. magnetostriction of conventional grain-oriented 3 1/4% silicon-iron and more highly oriented silicon-iron has been measured from room temperature up to the Curie point using high temperature strain gauges. Curves of magnetostriction plotted against flux density showed that a definite change in the magnetization process occurred at about 300° C extending to 400° C for both types of material. This was considered to be due to the onset of magnetic annealing, considerably modified by the effect of the coating on the materials. From the experimental results the magnetostriction constant ₁₀₀ has been calculated using a predicted domain structure and was found to agree well with single crystal values apart from within the 300 to 400° C region.     

The behaviour of uranium oxides in low partial pressures of O2 studied using X-ray photoelectron spectroscopy

Non-stoichiometry, induced by exposure to oxygen and vacuum has been investigated for the uranium oxides UO₂, U₄O₉ and U₃O₈ using X-ray photoelectron spectroscopy. Each stoichiometric uranium oxide is shown to display a unique X-ray photoelectron spectrum which can be altered quite dramatically by changes in stoichiometry and explained by a defect cluster model.     

Conditions for copackaging rous sarcoma virus and murine leukemia virus Gag proteins during retroviral budding

Rous sarcoma virus (RSV) and murine leukemia virus (MLV) are examples of distantly related retroviruses that normally do not encounter one another in nature. Their Gag proteins direct particle assembly at the plasma membrane but possess very little sequence similarity. As expected, coexpression of these two Gag proteins did not result in particles that contain both. However, when the N-terminal membrane-binding domain of each molecule was replaced with that of the Src oncoprotein, which is also targeted to the cytoplasmic face of the plasma membrane, efficient copackaging was observed in genetic complementation and coimmunoprecipitation assays. We hypothesize that the RSV and MLV Gag proteins normally use distinct locations on the plasma membrane for particle assembly but otherwise have assembly domains that are sufficiently similar in function (but not sequence) to allow heterologous interactions when these proteins are redirected to a common membrane location.     

Fossils, molecules and embryos: new perspectives on the Cambrian explosion

The Cambrian explosion is named for the geologically sudden appearance of numerous metazoan body plans (many of living phyla) between about 530 and 520 million years ago, only 1.7% of the duration of the fossil record of animals. Earlier indications of metazoans are found in the Neoproterozic; minute trails suggesting bilaterian activity date from about 600 million years ago. Larger and more elaborate fossil burrows appear near 543 million years ago, the beginning of the Cambrian Period. Evidence of metazoan activity in both trace and body fossils then increased during the 13 million years leading to the explosion. All living phyla may have originated by the end of the explosion. Molecular divergences among lineages leading to phyla record speciation events that have been earlier than the origins of the new body plans, which can arise many tens of millions of years after an initial branching. Various attempts to date those branchings by using molecular clocks have disagreed widely. While the timing of the evolution of the developmental systems of living metazoan body plans is still uncertain, the distribution of Hox and other developmental control genes among metazoans indicates that an extensive patterning system was in place prior to the Cambrian. However, it is likely that much genomic repatterning occurred during the Early Cambrian, involving both key control genes and regulators within their downstream cascades, as novel body plans evolved.     

Digital terrain modelling and industrial surface metrology — converging crafts

Quantitative characterisation of surface form, increasingly from digital 3-D height data, is cross-disciplinary and can be applied at any scale. Thus, separation of industrial-surface metrology from its Earth-science counterpart, (digital) terrain modelling, is artificial. Their growing convergence presents an opportunity to develop in surface morphometry a unified approach to surface representation. This paper introduces terrain modelling and compares it with metrology, noting their differences and similarities. Examples of potential redundancy among parameters illustrate one of the many issues common to both disciplines.