A new method for identifying and validating features from 2D sectional views

Feature identification is one of the key steps for 3D solids reconstruction from 2D vector engineering drawings using the volume-based method. In this paper, we propose a novel method to identify and validate features from sectional views. First, features are classified as explicit features (EPFs) and implicit features (IPFs), which are then identified in an order of priority using heuristic hints. We show that the problem of constructing EPFs can be formulated as a 0-1 integer linear program (ILP), and the IPFs are generated based on the understanding of semantic information of omitted projections in sectional views. Then, the Loop-Relation Graph (LRG) is introduced as a multi-connected-subgraph representation for describing the relations between loops and features. According to the LRG, a reasoning technique based on confidence is implemented to interactively validate features. This method can recover features without complete projections, and the level of understanding sectional views is improved. Full sections, partial sections, offset sections as well as revolved sections can be handled by our method. Several examples are provided to demonstrate the practicability of our approach.     

A mass spectrometric strategy for profiling glycoproteinoses, Pompe disease, and sialic acid storage diseases

Glycoproteinoses, Pompe disease, and sialic acid storage diseases are characterized by a massive accumulation of unprocessed oligosaccharides and/or glycoconjugates in urine. The identification of these glycocompounds is essential for a proper diagnosis. In this study, we investigated the potential of MALDI‐TOF‐MS to identify glycocompounds present in urine from patients with different inborn errors of glycan metabolism. Urinary glycocompounds were permethylated, and analyzed using GC‐MS and MALDI‐TOF‐MS. In order to confirm tentative assignments, a second aliquot of urine was purified on a C18 Sep‐Pak cartridge and glycocompounds were desalted on a column of nonporous graphitized carbon. The glycocompounds were then sequentially on‐plate digested using an array of exoglycosidases. A range of disease‐specific oligosaccharides as well as glycopeptides was identified for all oligosacchariduria models. In addition, free sialic acid accumulated in urine from a patient suffering from French‐type sialuria, has been detected by a GC‐MS approach, which could be applied to other sialic acid storage diseases. This procedure is simple, and can be performed in few simple steps in less than 24 h. This current method can be applied for newborn screening for other inherited metabolic diseases as well as for assessing treatments in clinical trials.     

Investigation of Functional Hemispheric Asymmetry of Language in Tinnitus Sufferers.

The authors tested functional hemispheric asymmetry through word dichotic listening and lateralized lexical decision tasks in tinnitus patients and controls stimulated by a continuous tinnitus-like noise to test the influence of a tinnitus-like external stimulation. A classic right-ear advantage was shown in the auditory task for all but right-ear tinnitus patients, who performed as equally badly when the stimuli were presented to the right and left ears. Concerning the visual task, all participants demonstrated the expected right visual field advantage for word stimuli. Moreover, those who submitted to external stimulation demonstrated normal asymmetric patterns. These data suggest a specific effect of tinnitus on central processing and provide evidence for a functional reorganization induced by this auditory phantom perception. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Addition of Synthetic Biomaterials to Deproteinized Bovine Bone Mineral (DBBM) for Bone Augmentation—A Preclinical In Vivo Study

(1) Aim: To investigate the effect of synthetic bone substitutes, α-tricalcium phosphate (α-TCP) or bi-layered biphasic calcium-phosphate (BBCP) combined with deproteinized bovine bone mineral (DBBM), on bone formation. (2) Methods: Thirty critical size defects were randomly treated with the following five different treatment modalities: (1) negative control (NC, empty), (2) DBBM, (3) α-TCP + DBBM (1:1), (4) BBCP 3%HA/97%α-TCP + DBBM (1:1), and (5) BBCP 6%HA/94%α-TCP + DBBM (1:1). The samples, at four weeks post-surgery, were investigated by micro-CT and histological analysis. (3) Results: A similar level of new bone formation was demonstrated in the DBBM with α-TCP bone substitute groups when compared to the negative control by histomorphometry. DBBM alone showed significantly lower new bone area than the negative control (p = 0.0252). In contrast to DBBM, the micro-CT analysis revealed resorption of the α-TCP + DBBM, BBCP 3%HA/97%α-TCP + DBBM and BBCP 6%HA/94%α-TCP + DBBM, as evidenced by a decrease of material density (p = 0.0083, p = 0.0050 and p = 0.0191, respectively), without changing their volume. (4) Conclusions: New bone formation was evident in all defects augmented with biomaterials, proving the osteoconductive properties of the tested material combinations. There was little impact of the HA coating degree on α-TCP in bone augmentation potential and material resorption for four weeks when mixed with DBBM.     

Distribution-free composite Shewhart-GWMA Mann-Whitney charts for monitoring the process location

The Mann-Whitney (MW) statistic is one of the most recommended two-sample statistical tests when the assumption of normality fails to hold due to its robustness and fascinating properties especially when small sample sizes are involved. In order to improve the sensitivity of the generally weighted moving average (GWMA) monitoring scheme toward the detection of large shifts, in this paper, a new distribution-free phase II composite Shewhart-GWMA (CSG) scheme is proposed using the MW U statistic. The performance of the proposed scheme is investigated using the average run-length (ARL) and average extra quadratic loss (AEQL) values through extensive simulations. The performance of this newly proposed monitoring scheme is found to be superior when compared to numerous memory-type MW schemes (some existing and others introduced in this paper) in many situations. An illustrative example is given to demonstrate the implementation of the CSG MW U scheme using real-life data.     

Generally weighted moving average monitoring schemes: Overview and perspectives

An overview of monitoring schemes from a class called generally weighted moving average (GWMA) is provided. A GWMA scheme is an extended version of the exponentially weighted moving average (EWMA) scheme with an additional adjustment parameter that introduces more flexibility in the GWMA model as it adjusts the kurtosis of the weighting function so that the GWMA scheme can be designed such that it has an advantage over the corresponding EWMA scheme in the detection of certain shift values efficiently. The parametric and distribution-free GWMA schemes to monitor various quality characteristics and its existing enhanced versions (ie, double GWMA, composite Shewhart-GWMA, mixed GWMA-CUSUM, and mixed CUSUM-GWMA) have better performance than their corresponding EWMA counterparts in many situations; hence, all such existing research works discussing GWMA-related schemes (ie, 66 publications in total) are documented and categorized in such a manner that it is easy to identify research gaps. Finally, a number of possible future research ideas are provided.     

Distribution-free double-sampling precedence monitoring scheme to detect unknown shifts in the location parameter

In most applications, parametric monitoring schemes are used to monitor the majority of industrial and nonindustrial processes in order to improve the quality of the outputs or services. However, parametric monitoring schemes are known to underperform when the normality assumption is not met or when there is not enough information about the symmetry or asymmetry nature of the process underlying distribution. Hence, in this paper, a new nonparametric Phase II Shewhart-type double-sampling (DS) monitoring scheme based on the precedence statistic is proposed in order to efficiently monitor quality processes when the underlying process distribution departs from normality. The performance is investigated using the average run length (ARL), standard deviation of the run length (SDRL), expected ARL (EARL) and expected average number of observations to signal (EANOS), and the average sample sizes (ASS) metrics. The latter metrics are computed using Monte Carlo simulation and exact formulae. In general, it is shown that the new DS precedence scheme outperforms the existing basic Shewhart precedence scheme with and without supplementary runs rules in many situations. A real-life illustrative example based on a filling process of milk bottles is provided to demonstrate the application and implementation of the new DS precedence monitoring scheme.     

Robust shape normalization of 3D articulated volumetric models

3D shape normalization is a common task in various computer graphics and pattern recognition applications. It aims to normalize different objects into a canonical coordinate frame with respect to rigid transformations containing translation, rotation and scaling in order to guarantee a unique representation. However, the conventional normalization approaches do not perform well when dealing with 3D articulated objects.To address this issue, we introduce a new method for normalizing a 3D articulated object in the volumetric form. We use techniques from robust statistics to guide the classical normalization computation. The key idea is to estimate the initial normalization by using implicit shape representation, which produces a novel articulation insensitive weight function to reduce the influence of articulated deformation. We also propose and prove the articulation insensitivity of implicit shape representation. The final solution is found by means of iteratively reweighted least squares. Our method is robust to articulated deformation without any explicit shape decomposition. The experimental results and some applications are presented for demonstrating the effectiveness of our method.     

A flexible-arm as manipulator position and force detection unit

This paper presents a self-sensory robot arm to two basic sensing problems in control of flexible manipulators: detection of the position and orientation variations due to structural deformation and detection of the contact force of end-effector when manipulator interacts with its environment. Taking advantage of structural flexibility, a flexible robot arm with strain gauges distributed on it acts as a sensing unit. The position and orientation of flexible arm are expressed as a function of curvature of the arm. An interpolation technique gives this continuous curvature function from a finite set of measurements made with strain gauges. A relation between strain measurements and endpoint force of flexible arm is developed and the contact force of end-effector is then determined using a force propagation algorithm. The proposed technique and algorithm were implemented and evaluated in a laboratorial flexible arm. Experimental validations using a vision system and two force sensors have shown that the self-sensory flexible arm can provide accurate endpoint position and force in both static and dynamic loading situations.     

Immunohistochemical Evaluation of Periodontal Regeneration Using a Porous Collagen Scaffold

(1) Aim: To immunohistochemically evaluate the effect of a volume-stable collagen scaffold (VCMX) on periodontal regeneration. (2) Methods: In eight beagle dogs, acute two-wall intrabony defects were treated with open flap debridement either with VCMX (test) or without (control). After 12 weeks, eight defects out of four animals were processed for paraffin histology and immunohistochemistry. (3) Results: All defects (four test + four control) revealed periodontal regeneration with cementum and bone formation. VCMX remnants were integrated in bone, periodontal ligament (PDL), and cementum. No differences in immunohistochemical labeling patterns were observed between test and control sites. New bone and cementum were labeled for bone sialoprotein, while the regenerated PDL was labeled for periostin and collagen type 1. Cytokeratin-positive epithelial cell rests of Malassez were detected in 50% of the defects. The regenerated PDL demonstrated a larger blood vessel area at the test (14.48% ± 3.52%) than at control sites (8.04% ± 1.85%, p = 0.0007). The number of blood vessels was higher in the regenerated PDL (test + control) compared to the pristine one (p = 0.012). The cell proliferative index was not statistically significantly different in pristine and regenerated PDL. (4) Conclusions: The data suggest a positive effect of VCMX on angiogenesis and an equally high cell turnover in the regenerated and pristine PDL. This VCMX supported periodontal regeneration in intrabony defects.