非水基凝胶注模成形高速钢粉末的研究

采用自主开发的非水基凝胶注模工艺,对高速钢粉末进行了凝胶注模的研究。所开发的非水基凝胶注模体系能够为金属粉末的成形开辟一种新型的方法。     

基于网络化制造的个性化定制系统的实现

在研究个性化产品定制生产模式的基础上,提出了一种针对单件小批量生产模式下大型机械产品的个性化定制系统的框架,并分析该系统的工作流程.提出了一种新的网络化制造平台下个性化产品定制系统中客户满意度的数学模型,开发了面向客户的个性化产品定制原型系统,可以让客户提出对产品的个性化需求,与设计人员共同定制出满足客户个性化需要的产品,为企业有效地满足客户多品种、小批量、多批次、短周期和高质量的消费需求提供一种新的途径.     

变幅单/多轴混合加载下GH4169光滑件的弹塑性有限元分析

对承受变幅单轴和变幅非比例多轴加载的镍基合金GH4169光滑薄壁管进行了有限元分析。使用ANSYS有限元分析软件进行有限元建模,采用Von Mises屈服准则和多线性随动强化准则来描述变幅弹塑性特性。结合三角波加载,在柱坐标系下对试样一端加载轴向位移和周向位移来实现拉扭应变加载。通过对光滑薄壁管件的有限元分析结果与试验结果进行比较,说明此方法对变幅单多轴加载弹塑性分析的正确性和实用性。     

基于Pro/E环境的加工特征信息获取研究

简要介绍了Pro/Enginger软件规范化建模的思想;依据特征提取对象的几何层次等级和对模型数据结构树的访问深度,深入研究了Pro/E环境下几何特征信息提取及识别的方法;对模具零件的加工特征进行了系统分类,得到模具零件加工特征的预定义特征库;提出了采用特征映射和人机交互定义实现模具零件由设计特征到加工特征的转换方法,并通过使用Pro/Toolkit在Pro/E模具设计环境下实现了零件加工特征信息提取。     

自行车蛇形弹簧减震器的设计与实验

作者针对传统自行车减震装置结构复杂的缺点,研制了一种新型自行车蛇形弹簧减震装置。首先采用理论计算设计了弹簧的外形尺寸,然后对不同尺寸的弹簧进行力学性能和减震性能测试。实验结果表明,蛇形弹簧是一种结构简单、适用性强、减震性能良好的自行车减震装置。     

氢氧化铝阻燃剂的表面改性及其在软质聚氯乙烯中的应用

采用不同的表面改性剂对氢氧化铝进行湿法表面改性处理,研究了氢氧化铝阻燃剂对软质聚氯乙烯(PVC)体系的阻燃性能和机械力学性能的影响,同时考察了阻燃协效剂对软质PVC体系的阻燃性能和机械力学性能的影响。结果表明:最佳的表面改性剂为硬脂酸钠,氢氧化铝阻燃剂的添加量为60g/g时体系的综合性能较好。加入阻燃协效剂后,体系的阻燃性能有大幅度的提高。     

汶川地震灾区城市供水的水质风险和应急处理技术与工艺

对汶川大地震后震区饮用水水源存在的次生污染风险进行分析,其中微生物浓度升高是首要风险,同时还存在大量使用消杀剂引起的杀虫剂污染和水源臭味增强的风险。针对这些风险,开展了一系列应急处理技术的验证性试验,提出了保障性应急处理工艺、强化吸附应急处理工艺和强化氧化应急处理工艺三种方案,以应对可能出现的震后次生水源污染,确保城市饮用水水质安全。     

A Novel L-Phenylalanine Dipeptide Inhibits the Growth and Metastasis of Prostate Cancer Cells via Targeting DUSP1 and TNFSF9

Prostate cancer (PCa) is a common malignant cancer of the urinary system. Drug therapy, chemotherapy, and radical prostatectomy are the primary treatment methods, but drug resistance and postoperative recurrence often occur. Therefore, seeking novel anti-tumor compounds with high efficiency and low toxicity from natural products can produce a new tumor treatment method. Matijin-Su [N-(N-benzoyl-L-phenylalanyl)-O-acetyl-L-phenylalanol, MTS] is a phenylalanine dipeptide monomer compound that is isolated from the Chinese ethnic medicine Matijin (Dichondra repens Forst.). Its derivatives exhibit various pharmacological activities, especially anti-tumor. Among them, the novel MTS derivative HXL131 has a significant inhibitory effect against prostate tumor growth and metastasis. This study is designed to investigate the effects of HXL131 on the growth and metastasis of human PCa cell lines PC3 and its molecular mechanism through in vitro experiments combined with proteomics, molecular docking, and gene silencing. The in vitro results showed that HXL131 concentration dependently inhibited PC3 cell proliferation, induced apoptosis, arrested cell cycle at the G2/M phase, and inhibited cell migration capacity. A proteomic analysis and a Western blot showed that HXL131 up-regulated the expression of proliferation, apoptosis, cell cycle, and migration-related proteins CYR61, TIMP1, SOD2, IL6, SERPINE2, DUSP1, TNFSF9, OSMR, TNFRSF10D, and TNFRSF12A. Molecular docking, a cellular thermal shift assay (CETSA), and gene silencing showed that HXL131 had a strong binding affinity with DUSP1 and TNFSF9, which are important target genes for inhibiting the growth and metastasis of PC3 cells. This study demonstrates that HXL131 exhibited excellent anti-prostate cancer activity and inhibited the growth and metastasis of prostate cancer cells by regulating the expression of DUSP1 and TNFSF9.     

The Role of Circular RNAs in the Physiology and Pathology of the Mammalian Ovary

Circular RNAs (circRNAs) are an abundant class of endogenous non-coding RNAs (ncRNAs) generated from exonic, intronic, or untranslated regions of protein-coding genes or intergenic regions. The diverse, stable, and specific expression patterns of circRNAs and their possible functions through cis/trans regulation and protein-coding mechanisms make circRNA a research hotspot in various biological and pathological processes. It also shows practical value as biomarkers, diagnostic indicators, and therapeutic targets. This review summarized the characteristics, classification, biogenesis and elimination, detection and confirmation, and functions of circRNAs. We focused on research advances circRNAs in the mammalian ovary under conditions including ovarian cancer, polycystic ovarian syndrome (PCOS), and maternal aging, as well as during reproductive status, including ovarian follicle development and atresia. The roles of circRNAs in high reproductive traits in domestic animals were also summarized. Finally, we outlined some obstructive factors and prospects to work with circRNA, aiming to provide insights into the functional research interests of circRNAs in the reproduction and gynecology areas.