A relativistic extension of the complex scaling method using oscillator basis functions

We develop the complex scaling method within the relativistic framework by expanding the Dirac spinors in the complete set of eigensolutions of a harmonic oscillator potential, and present the theoretical formalism of describing the discrete bound and resonant states on the same footing. Based on a well established and frequently used model, we demonstrate the utility and applicability of the extended method and examine the stability of the results with respect to the variations of the parameters of the model. Satisfactory agreements are found for all the calculated results in comparison with some other calculations in references. Especially, the present calculation in the nonrelativistic limit gives a consistent result with that in the nonrelativistic calculation.     

Investigation of the Influence of Small Hole on the Fatigue Crack Growth Path

The goal of this paper is to investigate the fatigue crack growth (FCG) path in 7075-T6 aluminum alloy affected by small hole. The codes ANSYS and FRANC3D are jointly used to compute the stress intensity factors and predict the FCG path. The predicted results show that the fatigue crack turns its growth direction toward the hole. The different locations and sizes of single hole have different influences on the FCG paths, while two symmetrically distributed holes have no effects on the FCG path. The predicted FCG paths are validated by the related FCG test results.     

Schottky diode fabricated on a single crystalline diamond rod

The fabrication process of Al/diamond Schottky diodes on single crystalline diamond rods (SCDRs) was demonstrated. SCDRs of submicron diameters were obtained by etching a polished polycrystalline diamond film in oxygen plasma. The as-scratched SCDR was confirmed to be single crystalline diamond by electron diffraction measurements showing the same fuzzy spot pattern at different parts of an SCDR. Each SCDR was extracted from a grain in the polycrystalline film where the grain size served as a limit of the length of an SCDR. Al/Ti and Al metals were deposited to form ohmic and Schottky contacts, respectively. A hydrogen plasma treatment is an essential step prior to the formation of an Al/diamond Schottky contact in order to improve the device performance. The submicron scale Al/diamond Schottky diode exhibits a very high current density of 1.4 × 10(4) A cm(-2) at a forward bias (V(F)) voltage of - 3 V.     

Insular cortex and consummatory successive negative contrast in the rat.

Rats that are expecting a high value reward (e.g., 1.0 M sucrose) show an exaggerated underresponding when they are instead given a low value reward (e.g., 0.15% saccharin), an effect termed successive negative contrast (SNC). In the present experiment, insular cortex-lesioned (ICX) rats showed normal responsivity to sucrose and saccharin prior to the reward downshift. However, when switched from sucrose to saccharin during the postshift trials these rats displayed no evidence of SNC. Indeed, over the downshift trials these ICX rats consistently drank more saccharin than the ICX rats maintained on saccharin throughout the experiment. Potential interpretations are discussed including a lesion-induced impairment in the ability to accurately recognize the novelty of the postshift saccharin stimulus. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Fabrication of submicron scale vertically aligned diamond rods by mask-free oxygen plasma etching

A mask-free plasma etching process is described to fabricate 6 μm long submicron diamond rods (SDRs) in long conical shape. Polished polycrystalline diamond is etched in oxygen plasma ignited at a pressure of 10 mTorr by radio-frequency power of 100 W at 13.56 MHz. Each SDR is a bi-crystal, consisting of two diamond crystallites of micron size. The SDR is coated with a Fe₂O₃ layer, as characterized by Auger electron spectroscopy, X-ray photoemission microscopy, and transmission electron microscopy. We propose that a “self-forming” mask of Fe₂O₃ is generated during the etching process in which iron atoms sputtered from the substrate holder are deposited and oxidized on the diamond surface forming “micromask” that protects the underlying diamond and promotes the formation of SDRs.     

液相色谱-质谱法分析鉴定红芽木的功能性成分及其生物活性研究

目的 分析红芽木的化学成分,并对其抗氧化、降糖及降脂功能活性进行研究。方法 采用液质-联用仪采集数据,对各色谱峰的质谱数据进行解析、结构推测和确认;采用自由基清除能力方法对红芽木样品抗氧化活性进行研究;考察红芽木对α-葡萄糖苷酶抑制活性及对胰岛素抵抗的影响;通过建立人肝癌高脂模型测试红芽木的降脂活性。结果 从红芽木中共鉴定了68个化合物,抗氧化结果显示红芽木清除DPPH及ABTS+自由基的IC50分别为0.21±0.05 mg/mL、0.14±0.03 mg/mL;红芽木对α-葡萄糖苷酶抑制活性的IC50分别为63.52±3.12 μg/mL;降糖试验结果显示可以改善HepG2细胞的胰岛素抵抗;降脂试验结果显示红芽木提取物具有一定的降脂作用。结论 红芽木化学成分丰富,并具有较好的抗氧化、降糖及降脂活性。     

Systems Approach to Pathogenic Mechanism of Type 2 Diabetes and Drug Discovery Design Based on Deep Learning and Drug Design Specifications

In this study, we proposed a systems biology approach to investigate the pathogenic mechanism for identifying significant biomarkers as drug targets and a systematic drug discovery strategy to design a potential multiple-molecule targeting drug for type 2 diabetes (T2D) treatment. We first integrated databases to construct the genome-wide genetic and epigenetic networks (GWGENs), which consist of protein–protein interaction networks (PPINs) and gene regulatory networks (GRNs) for T2D and non-T2D (health), respectively. Second, the relevant “real GWGENs” are identified by system identification and system order detection methods performed on the T2D and non-T2D RNA-seq data. To simplify network analysis, principal network projection (PNP) was thereby exploited to extract core GWGENs from real GWGENs. Then, with the help of KEGG pathway annotation, core signaling pathways were constructed to identify significant biomarkers. Furthermore, in order to discover potential drugs for the selected pathogenic biomarkers (i.e., drug targets) from the core signaling pathways, not only did we train a deep neural network (DNN)-based drug–target interaction (DTI) model to predict candidate drug’s binding with the identified biomarkers but also considered a set of design specifications, including drug regulation ability, toxicity, sensitivity, and side effects to sieve out promising drugs suitable for T2D.     

Evaluating residual compressive strength of concrete at elevated temperatures using ultrasonic pulse velocity

In this paper, the ultrasonic pulse velocity (UPV) is used to quantitatively evaluate the residual compressive strength of concrete subjected to elevated temperatures. A series of tests were performed to examine the relationship between the residual UPV and strength of concrete with different mixture proportions at elevated temperatures. Cylindrical specimens were made of concrete with water–cement ratios of 0.58 and 0.68, and heated in an electric furnace at temperatures ranging from 400 to 600 °C. After exposing to the elevated temperature, the concrete specimens were cooled down in the ambient air and tested on different days. For each test, the pulse velocity and compressive strength were measured. Experimental results show that change in mixture proportion of concrete does not have a significant effect on the residual strength and UPV ratios of concrete subjected to elevated temperatures. This important finding considerably enhances the feasibility of using UPV for quantitative evaluation of the residual strength of fire-damaged concrete structures. The relationship between the residual strength ratio and the residual UPV ratio was developed and a general equation was proposed for residual strength prediction. Finally, this paper verifies the suitability of the proposed equation for predicting the residual strength ratios of different concrete specimens with the measured residual UPV ratios.     

乳清中酪蛋白糖巨肽的制备及纯化研究

研究了凝乳酶对酪蛋白的最佳酶解条件,确定了其最佳酶解参数为：酶解温度50℃,pH6.5,酶和底物比3%,酶解时间90 min.酶解后通过12%TCA沉淀法得到纯度为85.25%的酪蛋白糖巨肽.     

直投式酸奶发酵剂增菌培养基的优化

在基础培养基的基础上确定了嗜热链球菌（S.t）和保加利亚乳杆菌（L.b）的增菌配方分别为：S.t（平菇浸汁14 mL、胡萝卜汁10 mL,玉米浆0.6 mL,Vc 0.2 g）和L.b（啤酒10 mL,番茄汁10 mL,胡萝卜汁15 mL,平菇浸汁16 mL）;同时测定了其最佳培养时间.