Fast, ultrasensitive virus detection using a Young interferometer sensor

We report the application of an integrated optical Young interferometer sensor for ultrasensitive, real-time, direct detection of viruses. We have validated the sensor by detecting herpes simplex virus type 1 (HSV-1), but the principle is generally applicable. Detection of HSV-1 virus particles was performed by applying the virus sample onto a sensor surface coated with a specific antibody against HSV-1. The performance of the sensor was tested by monitoring virus samples at clinically relevant concentrations. We show that the Young interferometer sensor can specifically and sensitively detect HSV-1 at very low concentrations (850 particles/mL). We have further demonstrated that the sensor can specifically detect HSV-1 suspended in serum. Extrapolation of the results indicates that the sensitivity of the sensor approaches the detection of a single virus particle binding, yielding a sensor of unprecedented sensitivity with wide applications for viral diagnostics.     

Transport mode preferences,risk perception and worry in a Norwegian urban population

The main aim of the present study was to compare risk perception among Norwegians (n = 512) living in the region of Oslo. This study was part of an ERANET 13 project entitled PETRIS, Perception of transport risk in France and Norway. The data collection was carried out in January 2011. The response rate was 51 percent. The results showed that respondents, divided in two groups according to their transport mode preferences, assessed differently risk perception in public and private transportation. Respondents who preferred collective transportation assessed the probability of experiencing criminality in collective transport modes as higher than those who preferred private modes. They were also more worried of experiencing accidents, criminality, and terror attacks in collective transportation. The relationship between transport mode preferences and use, risk perception and worry are discussed.     

Steering molecular organization and host-guest interactions using two-dimensional nanoporous coordination systems

Metal-organic coordination networks (MOCNs) have attracted wide interest because they provide a novel route towards porous materials that may find applications in molecular recognition, catalysis, gas storage and separation. The so-called rational design principle-synthesis of materials with predictable structures and properties-has been explored using appropriate organic molecular linkers connecting to metal nodes to control pore size and functionality of open coordination networks. Here we demonstrate the fabrication of surface-supported MOCNs comprising tailored pore sizes and chemical functionality by the modular assembly of polytopic organic carboxylate linker molecules and iron atoms on a Cu(100) surface under ultra-high-vacuum conditions. These arrays provide versatile templates for the handling and organization of functional species at the nanoscale, as is demonstrated by their use to accommodate C(60) guest molecules. Temperature-controlled studies reveal, at the single-molecule level, how pore size and chemical functionality determine the host-guest interactions.     

Simulating the spread of opinions in online social networks when targeting opinion leaders

An increasing number of people are joining online social networks. By interacting with each other, network members influence one another’s opinion. These influencing effects can be utilized by marketing. A wave of influence can be triggered by addressing only a few opinion leaders in the network. Targeting the right opinion leaders is a big challenge. This paper presents a new approach which simulates the spread of opinions when influencing certain opinion leaders. In contrast to other approaches, the influencing effects are not assumed but revealed by real data. The principles of opinion formation are detected by ant mining algorithms before they are applied to simulate the spread of opinions. The approach is applied to an online gaming community and provides valuable insights for marketing.     

Refined Epistemic Entrenchment

Epistemic entrenchment, as presented by Gärdenfors and Makinson (1988) and Gärdenfors (1988), is a formalisation of the intuition that, when forced to choose between two beliefs, an agent will giveup the less entrenched one. While their formalisation satisfactorilycaptures the intuitive notion of the entrenchment of beliefs in a number ofaspects, the requirement that all wffs be comparable has drawn criticismfrom various quarters. We define a set of refined versions of theirentrenchment orderings that are not subject to the same criticism, andinvestigate the relationship between the refined entrenched orderings,the entrenchment orderings of Gärdenfors and Makinson, and AGM theorycontraction (Alchourrón et al., 1985). To conclude, we compare refinedentrenchment with two related approaches to epistemic entrenchment.     

Understanding unforeseen production downtimes in manufacturing processes using log data-driven causal reasoning

Journal of Intelligent Manufacturing - In discrete manufacturing, the knowledge about causal relationships makes it possible to avoid unforeseen production downtimes by identifying their root...     

Algorithm selection and instance space analysis for curriculum-based course timetabling

Journal of Scheduling - We propose an algorithm selection approach and an instance space analysis for the well-known curriculum-based course timetabling problem (CB-CTT), which is an important...     

Decimal shifting for an exact floating point representation

A floating point representation which permits exact conversion of decimal numbers is discussed. This requires the exponent to represent a power of ten, and thus decimal shifts of the binary mantissa are needed. A specialized design is analyzed for the problem of division by ten, which is needed for decimal shifting.     

IEEE 802.21: Media independence beyond handover

The IEEE 802.21 standard facilitates media independent handovers by providing higher layer mobility management functions with common service primitives for all technologies. Right after the base specification was published, several voices rose up in the working group advocating to broaden the scope of IEEE 802.21 beyond handovers. This paper aims at updating the reader with the main challenges and functionalities required to create a Media Independence Service Layer, through the analysis of scenarios which are being discussed within the working group: 1) Wireless Coexistence, and 2) Heterogeneous Wireless Multihop Backhaul Networks.