A family of non-conforming elements and the analysis of Nitsche’s method for a singularly perturbed fourth order problem

In this paper we address several issues arising from a singularly perturbed fourth order problem with small parameter ε. First, we introduce a new family of non-conforming elements. We then prove that the corresponding finite element method is robust with respect to the parameter ε and uniformly convergent to order h ^1/2. In addition, we analyze the effect of treating the Neumann boundary condition weakly by Nitsche’s method. We show that such treatment is superior when the parameter ε is smaller than the mesh size h and obtain sharper error estimates. Such error analysis is not restricted to the proposed elements and can easily be carried out to other elements as long as the Neumann boundary condition is imposed weakly. Finally, we discuss the local error estimates and the pollution effect of the boundary layers in the interior of the domain.     

Narrow-FSK optical packet labeling scheme for optical ethernet networks

In this work, an intensity modulation/frequency-shift keying (IM/FSK) orthogonal modulation scheme is achieved by direct modulation of a distributed feedback laser source using its adiabatic chirp characteristics. Optical frequencies for "1" and "0" bits are separated only 0.7 GHz, obtaining a narrow-FSK modulation and, accordingly, a low residual intensity modulation. Ethernet frames at 1.25 Gb/s (GbE) are transmitted with a label inserted using coded mark inversion codification at a 155-Mb/s rate. Error rates for the Ethernet payload and for the label have been measured for different payload extinction ratios, showing the viability of this scheme for distances up to 25 km.     

High extinction ratio and high-temperature 2.5-Gb/s floor-free 1.3-/spl mu/m transmission with a directly modulated quantum dot laser

For the first time with a directly modulated InAs-GaAs quantum-dot laser, high extinction ratio (up to 17 dB) and 25/spl deg/C-85/spl deg/C single-mode-fiber data floor-free transmissions are achieved at 2.5 Gb/s. Moreover, an interferometric technique showed a nearly constant Henry factor /spl sim/2 until a bias current six times the threshold current.     

Evolution of fretting fatigue damage and relaxation of residual stress in shot-peened Ti-6Al-4V

The evolution of fretting fatigue damage was investigated in shot-peened Ti-6Al-4V samples, by measuring the changes in the surface residual stress, using the X-ray diffraction technique. The surface residual stress was found to relax as the number of fretting fatigue cycles increased. The relaxation behavior of the residual stress with the increasing number of fretting fatigue cycles was observed to occur in three stages. In the first 20 pct of the fretting fatigue life, a drastic relaxation was observed. In the second part (between 20 and 70 pct), a gradually increasing behavior was observed. During the last 20 to 30 pct of the fretting fatigue life, a dramatic relaxation of the residual stress was found to occur. A complete relaxation of the residual stress occurred in the fracture region. A scanning electron microscope observation of the microstructure of the damaged region was used to examine the mechanisms leading to the relaxation of the residual stress. The development of delaminations at the early stages of the accumulation of the fretting fatigue damage was observed to be the main cause of the initial relaxation. The generation of microcracks from the voids left behind by the delaminations is responsible for the additional relaxation of the residual stress. The coalescence of the microcracks generated from different delaminated regions produced yet more relaxation of residual stress and, ultimately, the final fracture of the specimen.     

On solving large strain hyperelastic problems with the natural element method

In this paper, an extension of the natural element method (NEM) is presented to solve finite deformation problems. Since NEM is a meshless method, its implementation does not require an explicit connectivity definition. Consequently, it is quite adequate to simulate large strain problems with important mesh distortions, reducing the need for remeshing and projection of results (extremely important in three‐dimensional problems). NEM has important advantages over other meshless methods, such as the interpolant character of its shape functions and the ability of exactly reproducing essential boundary conditions along convex boundaries. The α‐NEM extension generalizes this behaviour to non‐convex boundaries. A total Lagrangian formulation has been employed to solve different problems with large strains, considering hyperelastic behaviour. Several examples are presented in two and three dimensions, comparing the results with the ones of the finite element method. NEM performs better showing its important capabilities in this kind of applications. Copyright © 2004 John Wiley & Sons, Ltd.     

Nonlinear blind source separation using kernels

We derive a new method for solving nonlinear blind source separation (BSS) problems by exploiting second-order statistics in a kernel induced feature space. This paper extends a new and efficient closed-form linear algorithm to the nonlinear domain using the kernel trick originally applied in support vector machines (SVMs). This technique could likewise be applied to other linear covariance-based source separation algorithms. Experiments on realistic nonlinear mixtures of speech signals, gas multisensor data, and visual disparity data illustrate the applicability of our approach.     

Innovative methodology to improve the quality of electronic engineering formation through teaching industrial computer engineering

An innovative educational methodology adapted to the requirements of a new era with new societal and industrial challenges for electronic engineers is proposed in this paper. This active methodology, known as the Educational Innovation Project (EIP), is being studied in the Electronic Engineering (EE) degree of the Higher Technical School of Design Engineering at the Polytechnic University of Valencia, Valencia, Spain. The main objective of the EIP methodology is to improve the process of teaching and learning in order to increase student success. To accomplish this objective, the EIP method addresses various issues. From an organizational viewpoint, different structural aspects of the EE degree have been adapted, such as balancing and integrating lectures and laboratory sessions, advancing into interdisciplinary studies coordinated among all the subjects of the course, and strengthening the work in teams to tackle real engineer problems. The industrial computer engineering (ICE) subject is taken as a reference to show how these aspects have been applied. Regarding the faculty, lecturers participate in an open and permanent process of further training; attitudes toward cooperation and exchanges of experience among them are promoted; and research and reflection on new methodologies is encouraged. One of the challenges of the implementation of the EIP project is the development of multidisciplinary projects by team workers. The knowledge acquired from all the subjects is put into practice through the development of a common project to undertake real engineering problems.     

Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations

Mitophagy is the selective degradation of mitochondria by autophagy. It promotes the turnover of mitochondria and prevents the accumulation of dysfunctional mitochondria, which can lead to cellular degeneration. Mitophagy is known to be altered in several pathological conditions, especially in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). We recently demonstrated an increase in autophagy flux in lymphoblasts from ALS patients bearing a mutation in SOD1. Thus, the identification of mitophagy inhibitors may be a therapeutic option to recover mitochondrial homeostasis. Here, using a phenotypic mitophagy assay, we identified a new mitophagy inhibitor, the small molecule named IGS2.7 from the MBC library. Interestingly, the treatment of different cellular and in vivo models of ALS with mutations on SOD1 and TARDBP with this inhibitor restores autophagy to control levels. These results point mitophagy inhibitors, especially IGS2.7, to a new therapeutic approach for familial ALS patients.     

Unraveling Membrane Perturbations Caused by the Bacterial Riboregulator Hfq

Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, usually via its interaction with small regulatory RNAs. Previously, we showed that the Hfq C-terminal region forms an amyloid-like structure and that these fibrils interact with membranes. The immediate consequence of this interaction is a disruption of the membrane, but the effect on Hfq structure was unknown. To investigate details of the mechanism of interaction, the present work uses different in vitro biophysical approaches. We show that the Hfq C-terminal region influences membrane integrity and, conversely, that the membrane specifically affects the amyloid assembly. The reported effect of this bacterial master regulator on membrane integrity is discussed in light of the possible consequence on small regulatory RNA-based regulation.