The use of WIMS and CITATION codes in fuel loading required for the conversion of HEU MNSR core to LEU

The Nigerian Research Reactor-1 (NIRR-1) falls in the category of Miniature Neutron Source Reactors (MNSR) using a fuel of 90% HEU. It is therefore desirable to convert it from this enrichment to LEU (less than 20%) in conformity with the new global trend of making research reactor fuel as unattractive as possible to groups that may be interested in using such highly enriched cores for non-peaceful purposes. In this work, we have developed a computational scheme based on WIMS and CITATION that would theoretically achieve this objective as easily as possible. The scheme systematically reduces the enrichment from 90% (or any other initial values) to less than 20% in steps of 5% or any desired percentage variation. Two fuel types (UAl₄ and UO₂) are considered in here, while maintaining the size and geometry of the core as well as the excess reactivity (between 3.5 and 4 mk). Our results show that the U-235 loading increases sharply as enrichment decreases. It has also been noticed that at 5% enrichment the fuel loading for both types is 2505 g. However, at 90% enrichment, the loading drops sharply to 998 g for UAl₄ fuel and 946 g for UO₂ fuel. Below the enrichment of 5%, the operation of NIRR-1 with both fuel types can be considered unrealistic as this requires structural adjustment which the work tries to maintain constant.     

A stochastic mathematical model of 4D tumour spheroids with real-time fluorescent cell cycle labelling

In vitro tumour spheroids have been used to study avascular tumour growth and drug design for over 50 years. Tumour spheroids exhibit heterogeneity within the growing population that is thought to be related to spatial and temporal differences in nutrient availability. The recent development of real-time fluorescent cell cycle imaging allows us to identify the position and cell cycle status of individual cells within the growing spheroid, giving rise to the notion of a four-dimensional (4D) tumour spheroid. We develop the first stochastic individual-based model (IBM) of a 4D tumour spheroid and show that IBM simulation data compares well with experimental data using a primary human melanoma cell line. The IBM provides quantitative information about nutrient availability within the spheroid, which is important because it is difficult to measure these data experimentally.     

Improving the effectiveness of drinking-driving enforcement through increased efficiency

After reviewing previous enforcement programs designed to reduce driving while impaired (DWI). it is proposed that DWI enforcement could be more effective if it is conducted more efficiently. A number of legislative changes which may improve efficiency are discussed including: per se laws, lower legal limits, random roadside checks, random breath testing, mandatory blood tests for injured drivers, administrative adjudication and short-term licence suspensions. Several operational changes are also addressed: police officer selection and training, use of visual detection cues, timing and location of enforcement. It is concluded that DWI enforcement could be more effective if highly publicized, periodic, night-time random breath testing blitzes were conducted in an unpredictable fashion as far as time and location.     

Catalytic reduction of oxygen and hydrogen peroxide by nanoporous gold

Nanoporous gold (NPG) made by dealloying silver/gold alloys is a mesoporous metal combining high surface area and high conductivity. Recently, NPG has been shown to exhibit some of the high catalytic activity previously associated only with supported gold nanoparticles. Here we describe how NPG acts as a catalyst for the oxygen reduction reaction in both gas phase (in fuel cells) and aqueous environments (using rotating disk electrochemistry). NPG was found to reduce oxygen via an effectively 4-four electron route comprised of a first reduction of oxygen to hydrogen peroxide, and then an unusually active further catalytic reduction of hydrogen peroxide to water.     

Magnetic flux pinning and flux jumps in polycrystalline MgB2

MgB₂ polycrystalline samples were fabricated under varying conditions of isostatic pressing in argon gas. The critical current densities (J_C) were determined through measurements of hysteresis loops, and the highest value of J_C at 10 K was 1.9 × 10⁴ A/cm² at 4.8 T. The depinning temperatures were measured at various magnetic fields using the vibrating reed technique. Flux jumps appeared below 7.4 K. The hysteresis loops were carefully examined to determine the temperature and magnetic field range where flux jumps appeared.     

Architecture Considerations for Multi-Format Programmable Video Processors

Many different video processor architectures exist. Its architecture gives a processor strength for a particular application. Hardwired logic yields the best performance/cost, but a programmable processor is important for applications that support multiple coding standards, proprietary functions, or future changes to application requirements. Programmable video processor architectures achieve best performance through the use of parallelism at the data (SIMD), instruction (VLIW), and multiprocessor level, and optimally sized ALU, multiplier, and load/store datapaths. Because low-cost memory architectures are not optimized for the random access patterns of video processing, the performance of video processors is often limited by memory bandwidth rather than processing resources. Careful data organization alleviates memory bandwidth limitations. When choosing a video processor it is important to consider many factors, particularly performance, cost, power consumption, programmability, and peripheral support.

Differentiation of group I and group II strains of Clostridium botulinum by focal plane array Fourier transform infrared spectroscopy

A method was developed for whole-organism fingerprinting of Clostridium botulinum isolates by focal plane array Fourier transform infrared (FPA-FTIR) spectroscopy. A database of 150,000 infrared spectra of 44 strains of C. botulinum was acquired using a FPA-FTIR imaging spectrometer equipped with a 16 x 16 array detector to evaluate the ability of FTIR spectroscopy to differentiate the 44 strains. The database contained strains from C. botulinum groups I and II producing botulinum neurotoxin of serotypes A, B, E, and F. All strains were grown on each of three agar media (brain heart infusion, McClung Toabe agar base, and universal) prior to spectral acquisition. Given the dependence of the infrared spectra of microorganisms on the composition of the growth medium, the spectra were initially separated into three subsets corresponding to the three growth media employed. However, the replicate spectra of all strains, regardless of growth medium, were properly clustered by hierarchical cluster analysis based on differences in their infrared spectral profiles in three narrow spectral regions (1,428 to 1,412, 1,296 to 1,284, and 1,112 to 1,100 cm(-1)). The dendrogram generated from the FTIR data revealed complete separation between group I and group II strains. The spectral differences between group I and group II strains allowed accurate classification of C. botulinum strains at the group level in two blind validation studies (n = 40). These results demonstrate that FPA-FTIR spectroscopy has the potential for rapid discrimination of group I and group II C. botulinum strains in less than 3 min per sample.     

Simultaneous excitation of propagating and localized surface plasmon resonance in nanoporous gold membranes

Materials multifunctionality for optical sensing of adsorbates has obvious advantages-in addition to the potential for greater sensitivity, the different length scales associated with a variety of optical phenomena allow a greater variety of adsorption characteristics to be examined. Here, we show that ultrathin (approximately 100 nm) nanoporous gold membranes possess features of both planar metal films that exhibit propagating SPR excitations and nanofeatured metals that exhibit localized SPR excitations. This is the first report of such multifunctionality in an optically active metal. We give illustrative examples of using this material to probe biorecognition reactions and to probe the structure evolution of a layer-by-layer deposition of charged dendrimers. Our results are consistent with the very different lengths of the tail of the evanescent field decays associated with each of these plasmon excitation modes.