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排序方式: 共有2523条查询结果,搜索用时 859 毫秒
51.
52.
Yady J. Manrique Arron M. Sparkes Julie A.Y. Cichero Jason R. Stokes Lisa M. Nissen 《Drug development and industrial pharmacy》2016,42(9):1537-1544
Acetaminophen (paracetamol) is available in a wide range of oral formulations designed to meet the needs of the population across the age-spectrum, but for people with impaired swallowing, i.e. dysphagia, both solid and liquid medications can be difficult to swallow without modification. The effect of a commercial polysaccharide thickener, designed to be added to fluids to promote safe swallowing by dysphagic patients, on rheology and acetaminophen dissolution was tested using crushed immediate-release tablets in water, effervescent tablets in water, elixir and suspension. The inclusion of the thickener, comprised of xanthan gum and maltodextrin, had a considerable impact on dissolution; acetaminophen release from modified medications reached 12–50% in 30?min, which did not reflect the pharmacopeia specification for immediate release preparations. Flow curves reflect the high zero-shear viscosity and the apparent yield stress of the thickened products. The weak gel nature, in combination with high G' values compared to G'' (viscoelasticity) and high apparent yield stress, impact drug release. The restriction on drug release from these formulations is not influenced by the theoretical state of the drug (dissolved or dispersed), and the approach typically used in clinical practice (mixing crushed tablets into pre-prepared thickened fluid) cannot be improved by altering the order of incorporation or mixing method. 相似文献
53.
Waser J Ribičić H Fuchs R Hirsch C Schindler B Blöschl G Gröller ME 《IEEE transactions on visualization and computer graphics》2011,17(12):1872-1881
Flood disasters are the most common natural risk and tremendous efforts are spent to improve their simulation and management. However, simulation-based investigation of actions that can be taken in case of flood emergencies is rarely done. This is in part due to the lack of a comprehensive framework which integrates and facilitates these efforts. In this paper, we tackle several problems which are related to steering a flood simulation. One issue is related to uncertainty. We need to account for uncertain knowledge about the environment, such as levee-breach locations. Furthermore, the steering process has to reveal how these uncertainties in the boundary conditions affect the confidence in the simulation outcome. Another important problem is that the simulation setup is often hidden in a black-box. We expose system internals and show that simulation steering can be comprehensible at the same time. This is important because the domain expert needs to be able to modify the simulation setup in order to include local knowledge and experience. In the proposed solution, users steer parameter studies through the World Lines interface to account for input uncertainties. The transport of steering information to the underlying data-flow components is handled by a novel meta-flow. The meta-flow is an extension to a standard data-flow network, comprising additional nodes and ropes to abstract parameter control. The meta-flow has a visual representation to inform the user about which control operations happen. Finally, we present the idea to use the data-flow diagram itself for visualizing steering information and simulation results. We discuss a case-study in collaboration with a domain expert who proposes different actions to protect a virtual city from imminent flooding. The key to choosing the best response strategy is the ability to compare different regions of the parameter space while retaining an understanding of what is happening inside the data-flow system. 相似文献
54.
Michael J. Hirsch Panos M. Pardalos Mauricio G. C. Resende 《International Transactions in Operational Research》2011,18(4):493-511
The field of computer vision has experienced rapid growth over the past 50 years. Many computer vision problems have been solved using theory and ideas from algebraic projective geometry. In this paper, we look at a previously unsolved problem from object recognition, namely object recognition when the correspondences between the object and image data are not known a priori. We formulate this problem as a mixed‐integer non‐linear optimization problem in terms of the unknown projection relating the object and image, as well as the unknown assignments of object points and lines to those in the image. The global optimum of this problem recovers the relationship between the object points and lines with those in the image. When certain assumptions are enforced on the allowable projections mapping the object into the image, a proof is provided which permits one to solve the optimization problem via a simple decomposition. We illustrate this decomposition approach on some example scenarios. 相似文献
55.
Context
Information system development (ISD) has been plagued with high failure rates. This is partially due to the activities being a combination of both a technical and social processes involving stakeholders with conflicting interests.Objective
Existing software risk management theories and frameworks offer limited suggestions for actions that can be taken to reduce the chance of failure of ISD projects. Our objective is to examine the connections among some of the more important user related risks in order to shed light on how specific strategies enhance the chance of project success.Method
We conducted a sample of information systems project managers to test a multivariate model to explain the impact of pursuing a partnership with users on the conflicts that arise between users and developers, role ambiguity, and subsequent impact on project performance.Results
The proposed model was supported, suggesting that user-developer conflict and role ambiguity have a negative impact on performance estimation difficulty, which negatively affects project performance.Conclusion
Pursuit of project partnering yields a number of significant relationships in the model indicating an organization can implement practices that reduce risks associated with role ambiguity and conflict in system development projects. 相似文献56.
57.
Marc Baboulin Alfredo Buttari Jack Dongarra Jakub Kurzak Julie Langou Julien Langou Piotr Luszczek Stanimire Tomov 《Computer Physics Communications》2009,180(12):2526-2533
On modern architectures, the performance of 32-bit operations is often at least twice as fast as the performance of 64-bit operations. By using a combination of 32-bit and 64-bit floating point arithmetic, the performance of many dense and sparse linear algebra algorithms can be significantly enhanced while maintaining the 64-bit accuracy of the resulting solution. The approach presented here can apply not only to conventional processors but also to other technologies such as Field Programmable Gate Arrays (FPGA), Graphical Processing Units (GPU), and the STI Cell BE processor. Results on modern processor architectures and the STI Cell BE are presented.
Program summary
Program title: ITER-REFCatalogue identifier: AECO_v1_0Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AECO_v1_0.htmlProgram obtainable from: CPC Program Library, Queen's University, Belfast, N. IrelandLicensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.htmlNo. of lines in distributed program, including test data, etc.: 7211No. of bytes in distributed program, including test data, etc.: 41 862Distribution format: tar.gzProgramming language: FORTRAN 77Computer: desktop, serverOperating system: Unix/LinuxRAM: 512 MbytesClassification: 4.8External routines: BLAS (optional)Nature of problem: On modern architectures, the performance of 32-bit operations is often at least twice as fast as the performance of 64-bit operations. By using a combination of 32-bit and 64-bit floating point arithmetic, the performance of many dense and sparse linear algebra algorithms can be significantly enhanced while maintaining the 64-bit accuracy of the resulting solution.Solution method: Mixed precision algorithms stem from the observation that, in many cases, a single precision solution of a problem can be refined to the point where double precision accuracy is achieved. A common approach to the solution of linear systems, either dense or sparse, is to perform the LU factorization of the coefficient matrix using Gaussian elimination. First, the coefficient matrix A is factored into the product of a lower triangular matrix L and an upper triangular matrix U. Partial row pivoting is in general used to improve numerical stability resulting in a factorization PA=LU, where P is a permutation matrix. The solution for the system is achieved by first solving Ly=Pb (forward substitution) and then solving Ux=y (backward substitution). Due to round-off errors, the computed solution, x, carries a numerical error magnified by the condition number of the coefficient matrix A. In order to improve the computed solution, an iterative process can be applied, which produces a correction to the computed solution at each iteration, which then yields the method that is commonly known as the iterative refinement algorithm. Provided that the system is not too ill-conditioned, the algorithm produces a solution correct to the working precision.Running time: seconds/minutes 相似文献58.
This paper reports on a method for the investigation of mechanical stress on MEMS sensor and actuator structures due to packaging
processes. A silicon test chip is developed and manufactured to validate the simulation results. Finite element analysis (FEA)
is used to optimize the geometric parameters and to find a stress sensitive sensor geometry. A diaphragm structure is used
as mechanical amplifier for bulk induced stresses during the packaging process. Piezo resistive solid state resistors are
doped into the surface of the chip to measure the stress in the diaphragms and at the contact pads being most significant
locations for analysis. A high precision ohmmeter was used to measure the resistance prior and past the packaging process.
The captured data allows for computation of the resulting stress loads in magnitude. Therefore, a stress evaluation of different
packaging technologies is conducted and the impact of the packaging process on reliability can be estimated immediately. 相似文献
59.
Liz de Rome Elizabeth A. Taylor Rodney J. Croft Julie Brown Michael Fitzharris 《Ergonomics》2016,59(4):504-513
Motorcycle protective clothing can be uncomfortably hot during summer, and this experiment was designed to evaluate the physiological significance of that burden. Twelve males participated in four, 90-min trials (cycling 30 W) across three environments (25, 30, 35 °C [all 40% relative humidity]). Clothing was modified between full and minimal injury protection. Both ensembles were tested at 25 °C, with only the more protective ensemble investigated at 30 and 35 °C. At 35 °C, auditory canal temperature rose at 0.02 °C min?1 (SD 0.005), deviating from all other trials (p < 0.05). The thresholds for moderate (>38.5 °C) and profound hyperthermia (>40.0 °C) were predicted to occur within 105 min (SD 20.6) and 180 min (SD 33.0), respectively. Profound hyperthermia might eventuate in ~10 h at 30 °C, but should not occur at 25 °C. These outcomes demonstrate a need to enhance the heat dissipation capabilities of motorcycle clothing designed for summer use in hot climates, but without compromising impact protection.
Practitioner’s Summary:
Motorcycle protective clothing can be uncomfortably hot during summer. This experiment was designed to evaluate the physiological significance of this burden across climatic states. In the heat, moderate (>38.5 °C) and profound hyperthermia (>40.0 °C) were predicted to occur within 105 and 180 min, respectively. 相似文献
60.
In early or preparatory design stages, an architect or designer sketches out rough ideas, not only about the object or structure being considered, but its relation to its spatial context. This is an iterative process, where the sketches are not only the primary means for testing and refining ideas, but also for communicating among a design team and to clients. Hence, sketching is the preferred media for artists and designers during the early stages of design, albeit with a major drawback: sketches are 2D and effects such as view perturbations or object movement are not supported, thereby inhibiting the design process. We present an interactive system that allows for the creation of a 3D abstraction of a designed space, built primarily by sketching in 2D within the context of an anchoring design or photograph. The system is progressive in the sense that the interpretations are refined as the user continues sketching. As a key technical enabler, we reformulate the sketch interpretation process as a selection optimization from a set of context‐generated canvas planes in order to retrieve a regular arrangement of planes. We demonstrate our system (available at http:/geometry.cs.ucl.ac.uk/projects/2016/smartcanvas/ ) with a wide range of sketches and design studies. 相似文献