印刷企业积极进取的力量

Julie：在过去的几周里，美国和世界金融市场经历了非常困难的时期。世界上一些大型的银行机构和投资公司纷纷破产或由政府接管。在未来的几周里，世界各地可能会有更多的金融公司带来更多的坏消息。许多金融专家们对世界经济充满沮丧和悲观的情绪。     

Full field measurement at the micro-scale using micro-interferometry

This paper presents micro-interferometry as a measurement technique to extract temperature profiles and/or mass transfer gradients rapidly and locally in micro-devices. Interferometry quantifies the phase change between two or more coherent light beams induced by temperature and/or mass concentration. Previous work has shown that temporal noise is a limiting factor in microscale applications. This paper examines phase stepping and heterodyne phase retrieval techniques with both CCD and CMOS cameras. CMOS cameras are examined owing to the high speed at which images can be acquired which is particularly relevant to heterodyne methods. It is found that heterodyne retrieval is five times better than phase stepping being limited to 0.01 rad or λ/628. This is twice the theoretical limit of λ/1,000. The technique is demonstrated for mixing in a T-junction with a 500 μm square channel and compared favourably to a theoretical prediction from the literature. Further issues regarding application to temperature measurements are discussed.     

A fast VQ codebook generation algorithm using codeword displacement

In this paper, we present a fast codebook generation algorithm called CGAUCD (Codebook Generation Algorithm Using Codeword Displacement) by making use of the codeword displacement between successive partition processes. By implementing a fast search algorithm named MFAUPI (Modified Fast Algorithm Using Projection and Inequality) for VQ encoding in the partition step of CGAUCD, the codebook generation time can be further reduced significantly. Using MFAUPI, the computing time of CGAUCD can be reduced by a factor of 4.7–7.6. Compared to Generalized Lloyd Algorithm (GLA), our proposed method can reduce the codebook generation time by a factor of 35.9–121.2. Compared to the best codebook generation algorithm to our knowledge, our approach can further reduce the corresponding computing time by 26.0–32.8%. It is noted that our proposed algorithm can generate the same codebook as that produced by the GLA. The superiority of our method is more remarkable when a larger codebook is generated.     

Empathy in preschool children: The development of the Southampton Test of Empathy for Preschoolers (STEP).

In this study, we investigated a new instrument: the Southampton Test of Empathy for Preschoolers (STEP). The test incorporated 8 video vignettes of children in emotional scenarios, assessing a child's ability to understand (STEP-UND) and share (STEP-SHA) in the emotional experience of a story protagonist. Each vignette included 4 emotions (angry, happy, fearful, sad) that reflected emotion judgments based on the protagonist's facial expression, situation, verbal cues, and desire. The STEP was administered to 39 preschool children, and internal reliability, concurrent validity, and construct validity were addressed. The results showed good internal consistency. They also highlighted moderate concurrent validity with parent-rated empathy, a measure of facial indices, and construct validity with teacher-rated prosocial behavior. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Life tasks, self-concept ideals, and cognitive strategies in a life transition.

This paper reports on data from a longitudinal study in which normative life tasks and individuals' personal versions of those tasks are investigated in the context of students making the transition from home and high school to college life. Analyses focus both on common patterns of life-task appraisal in interpersonal and achievement domains and on differences in the self-concepts and cognitive strategies that individual students bring to bear as they confront these normative pressures (Cantor & Kihlstrom, 1987). In particular, we investigate the impact of students' actual-ideal self-discrepancies (Higgins, Klein, & Strauman, 1985) on subjective stress and satisfaction in achievement and interpersonal life-task domains and suggest that self-concept discrepancy negatively affects adjustment in the achievement domain and positively affects social outcomes. Students using a defensive-pessimism strategy motivated themselves by confronting their anxieties in advance of stressful tasks, whereas those using an optimistic strategy assumed the best until proved otherwise—protecting self-esteem after the fact in the event of disappointment (Norem & Cantor, 1986a, 1986b). This analysis, thus, begins at the level of normative "readings" of life tasks in a shared transition period and gradually moves toward consideration of how individuals navigate those tasks in personally meaningful ways. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Do boys with attention-deficit/hyperactivity disorder have positive illusory self-concepts?

One hundred ninety-five boys with attention-deficit/hyperactivity disorder (ADHD) were compared with 73 comparison boys (M=9.83 years, SD=1.30) on self-perceptions relative to a teacher-rated criterion. Emphasis was placed on ADHD subgroup comparisons according to level of aggression, academic achievement, and depression compared with control boys. Consistent with the authors' prediction, ADHD boys overestimated relative to teacher report, more than did controls, in the scholastic competence, social acceptance, and behavioral conduct domains. Examination of discrepancy scores (child rating--teacher rating) by comorbidity subgroups suggested that aggressive and low-achieving ADHD boys tended to overestimate their competence the most in the domains in which they were the most impaired. Results are discussed in terms of prior literature on "positive illusions" in ADHD children. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

胶印的数字化变革在继续

全美印艺展（GRAPH EXPO）于10月26～29日在美国芝加哥成功举办。虽然面临着经济不景气，但本次展会则超出了预期，无论是参展商，还是参观者，都满意而归。本期邀请Andy和Julie与您一起感受2008年全美印艺展的气息。     

Supplementary WMS-III tables for determining primary subtest strengths and weaknesses.

It is common practice to evaluate the age-adjusted subtest scores from the Wechsler intelligence scales to determine strengths and weaknesses within a profile. The Wechsler Memory Scale-III (WMS-III; D. Wechsler, 1997a) represents a significant improvement over its predecessors and, for the first time, provides age-adjusted subtest scores for interpretation, just as the Wechsler intelligence scales have done for 60 years. It is reasonable to assume that examiners will evaluate the WMS-III subtest profiles for strengths and weaknesses. However, the WMS-III Administration and Scoring Manual and the WAIS-III—WMS-III Technical Manual (The Psychological Corporation, 1997) provide no assistance for accomplishing this goal. Data from the WMS-III standardization sample, as described in the WAIS-III-WMS-III Technical Manual, were used to develop tables for determining both confidence levels and infrequency of differences between individual subtest scores and the means of 5 subtest combinations that may be clinically relevant for individual cases. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Behavioral correlates of maternal depressive symptomatology in conduct-disorder children: II. Systemic effects involving fathers and siblings.

This study tested a systemic hypothesis of the relation between maternal depressive symptomatology and the behavior of conduct-disordered children (n?=?47) toward their mothers, fathers, and siblings. Maternal symptomatology interacted with the children's behavior toward all family members. Children whose mothers were distressed tended to be more compliant and less aversive toward them than toward their fathers, and the opposite applied to children whose mothers were not distressed. Comparable results were obtained in comparisons of child interactions with mothers and siblings, although in the latter case the children's behaviors differed in absolute magnitude as a function of their interaction partner. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A Novel Triple-Action Inhibitor Targeting B-Cell Receptor Signaling and BRD4 Demonstrates Preclinical Activity in Chronic Lymphocytic Leukemia

B-cell chronic lymphocytic leukemia (CLL) results from intrinsic genetic defects and complex microenvironment stimuli that fuel CLL cell growth through an array of survival signaling pathways. Novel small-molecule agents targeting the B-cell receptor pathway and anti-apoptotic proteins alone or in combination have revolutionized the management of CLL, yet combination therapy carries significant toxicity and CLL remains incurable due to residual disease and relapse. Single-molecule inhibitors that can target multiple disease-driving factors are thus an attractive approach to combat both drug resistance and combination-therapy-related toxicities. We demonstrate that SRX3305, a novel small-molecule BTK/PI3K/BRD4 inhibitor that targets three distinctive facets of CLL biology, attenuates CLL cell proliferation and promotes apoptosis in a dose-dependent fashion. SRX3305 also inhibits the activation-induced proliferation of primary CLL cells in vitro and effectively blocks microenvironment-mediated survival signals, including stromal cell contact. Furthermore, SRX3305 blocks CLL cell migration toward CXCL-12 and CXCL-13, which are major chemokines involved in CLL cell homing and retention in microenvironment niches. Importantly, SRX3305 maintains its anti-tumor effects in ibrutinib-resistant CLL cells. Collectively, this study establishes the preclinical efficacy of SRX3305 in CLL, providing significant rationale for its development as a therapeutic agent for CLL and related disorders.