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991.
R Lehtinen H Siev?nen J Viik V Turjanmaa K Niemel? J Malmivuo 《Canadian Metallurgical Quarterly》1996,78(9):1002-1006
In this comparative cross-sectional study, we evaluated whether a novel computerized diagnostic variable, ST-segment depression/heart rate ST/HR analysis during both the exercise and postexercise recovery phases of the exercise electrocardiography (ECG) test, can detect coronary artery disease more accurately than methods using either exercise or recovery phase alone. The study population comprised 347 clinical patients referred for a routine bicycle exercise ECG test at Tampere University Hospital, Finland. Of these, 127 had angiographically proven coronary artery disease, whereas 13 had no coronary artery disease according to angiography, 18 had no perfusion defect according to technetium-99m sestamibi single-photon emission computed tomography, and 189 were clinically normal with respect to cardiac diseases. For each patient, the maximum values of the ST/HR hysteresis, ST/HR index, end-exercise ST depression, and recovery ST depression were determined from the Mason-Likar modification of the standard 12-lead exercise electrocardiogram [aVL, aVR, and V1 excluded]. The diagnostic performance of these continuous diagnostic variables was compared by means of receiver-operating characteristic analysis. The area under the receiver-operating characteristic curve of the ST/HR hysteresis was 89%, which was significantly larger than that of the end-exercise ST depression (76%, p < or = 0.0001), recovery ST depression (84%, p = 0.0063), or ST/HR index (83%, p = 0.0023), indicating superior diagnostic performance of the ST/HR hysteresis independent of the partition value selection. In conclusion, computerized analysis of the HR-adjusted ST depression pattern during the exercise phase, integrated with the HR-adjusted ST depression pattern during the recovery phase after exercise, can significantly improve the diagnostic performance and clinical utility of the exercise ECG test for the detection of coronary artery disease. 相似文献
992.
E Asakura T Hanamura A Umemura K Yada T Yamauchi T Tanabe 《Canadian Metallurgical Quarterly》1996,195(3):300-313
M-CSF is a macrophage-lineage-specific growth factor that causes proliferation and differentiation of progenitor cells in the bone marrow. To investigate the effects of M-CSF on more matured cells, human monocytes were cultured in the presence or absence of M-CSF for 6 days. Addition of M-CSF at more than 10(2) U/ml resulted in higher viability and caused morphological differentiation to large macrophage-like cells. LPS-induced mediator production was also compared between M-CSF-treated and control cell. Monocytes were incubated with or without M-CSF for 3 days, and were stimulated with 1 microgram/ml of LPS for 2 days. IL-1 beta was not detected in the both culture supernatants, and PGE2 production was not influenced by M-CSF. However, amounts of G-CSF, GM-CSF, IL-6, and TNF-alpha produced in response to 1 microgram/ml of LPS were 1.5 to 2 times greater from monocytes treated with 10(4) U/ml of M-CSF than from control cells. The priming effect of M-CSF on LPS-induced cytokine production was found to require 3-day preincubation, and reached a maximum at the concentration of 10(4) U/ml. M-CSF-treated cells responded to a 10 times lower concentration of LPS than control cells in terms of cytokine production. M-CSF was also shown by flowcytometric analysis to influence the expression of CD14, a receptor for LPS, which might render monocytes more sensitive to LPS. 相似文献
993.
Male rats were tested for their sexual preference behavior at either 37, 70, 90, or 150 days of age on three different occasions; while still sexually naive, after sexual experience with a receptive female, and while sexually aroused by having initiated copulation. These tests resulted in the following findings: a) 37-day-old sexually naive males showed a preference for other males and failed to show a preference for either sex after exposure to females; b) 70- and 90-day-old males showed a statistically significant preference for the female after acquiring sexual experience; c) 150-day-old animals showed a female-oriented preference only after being sexually aroused with two intromissions preceding the preference test, and d) none of the age groups tested showed a female-oriented preference without previous exposure to females. It was then concluded that a) female-oriented behavior requires sexual experience and b) the effects of experience varies with age. 相似文献
994.
Significant amounts of bismuth can be removed from magnesium-lead alloys by crystallization of the intermetallic compounds
Mg0. 6573Pb0. 3427 and Mg0.662Pb0.338in the Mg2Pb, magnesium plumbide phase field of the Pb-Mg-Bi system. The results of the previous studies have been used to develop a
process for debismuthizing lead using controlled conditions for the crystallization of magnesium plumbide from alloys containing
0.03 to 0.06 wt Pct bismuth and magnesium whose concentration is determined by the relationship wt Pct Mg = 2.9 + 20 x wt
Pct Bi. A flow diagram showing the sequence of operations is presented together with a material balance, which was established
from data obtained from individual experiments simulating the previously mentioned unit operations, with a final product containing
less than 0.0010 wt Pct Bi. The process also includes the recycling of magnesium recovered by vacuum distillation. Additional
procedures are included to extend the process to treat alloys containing up to 1.5 wt pct bismuth. 相似文献
995.
K Jaton-Ogay S Paris M Huerre M Quadroni R Falchetto G Togni JP Latgé M Monod 《Canadian Metallurgical Quarterly》1994,14(5):917-928
Aspergillus fumigatus secretes a serine alkaline protease (ALP) and a metalloprotease (MEP) when the fungus is cultivated in the presence of collagen as sole nitrogen and carbon source. The gene encoding ALP was isolated and characterized previously. We report here the cloning and the sequencing of the gene encoding MEP. Genomic and cDNA clones were isolated from A. fumigatus libraries using synthetic oligonucleotides as probes. Stretches of the deduced amino acid sequence were found to be in agreement with the N-terminal amino acid sequence of MEP and with internal peptide sequences. The amino acid sequence of the enzyme contains a putative active-site sequence HEYTH homologous to the active site of other bacterial and eukaryotic zinc metalloproteases. Sequence analysis reveals that MEP has a pre-proregion consisting of 245 amino acid residues preceding the 388 amino acid residues of the mature region (molecular mass of 42 kDa). An alp mep mutant, deficient in proteolytic activity at neutral pH in vitro, was constructed and tested for pathogenicity in a murine model. No difference in pathogenicity was observed between the wild-type strain and the alp mep double mutant, suggesting that ALP and MEP are not essential for the invasion of the lung tissues by A. fumigatus. 相似文献
996.
997.
Object and texture classification using higher order statistics 总被引:5,自引:0,他引:5
Tsatsanis M.K. Giannakis G.B. 《IEEE transactions on pattern analysis and machine intelligence》1992,14(7):733-750
The problem of the detection and classification of deterministic objects and random textures in a noisy scene is discussed. An energy detector is developed in the cumulant domain by exploiting the noise insensitivity of higher order statistics. An efficient implementation of this detector is described, using matched filtering. Its performance is analyzed using asymptotic distributions in a binary hypothesis-testing framework. The object and texture discriminant functions are minimum distance classifiers in the cumulant domain and can be efficiently implemented using a bank of matched filters. They are immune to additive Gaussian noise and insensitive to object shifts. Important extensions, which can handle object rotation and scaling, are also discussed. An alternative texture classifier is derived from a ML viewpoint and is statistically efficient at the expense of complexity. The application of these algorithms to the texture-modeling problem is indicated, and consistent parameter estimates are obtained 相似文献
998.
S. I. Glinchak Yu. A. Egorov R. R. Aliev E. D. Radchenko B. K. Nefedov N. A. Grigor'ev 《Chemistry and Technology of Fuels and Oils》1992,28(3):175-177
Translated from Khimiya i Tekhonologiy Topliv i Masel, No. 3, pp. 33–34, March, 1992. 相似文献
999.
1000.
RM Torres CL Law L Santos-Argumedo PA Kirkham K Grabstein RM Parkhouse EA Clark 《Canadian Metallurgical Quarterly》1992,149(8):2641-2649
The human B lymphocyte-specific Ag, CD22, is a cell adhesion molecule expressed on the surface during a narrow window of B cell development, coincident with surface IgD. A ligand for CD22 has recently been identified on human T cells as the low molecular mass isoform of the leukocyte common Ag, CD45RO. CD22 has been reported to function in the regulation of both T and B cell activation in vitro. In this study, we report the isolation and expression of a molecular cDNA clone encoding the murine homologue of CD22, mCD22. Within their predicted protein sequences, murine and human sequences overall have 62% identity, which includes 18 of 20 extracellular cysteines and six of six cytoplasmic tyrosines. BHK cells transfected with mCD22 cDNA specifically adhere to resting and activated T lymphocytes and in addition bound activated, but not resting, B cells. Five Th clones were analyzed for their ability to adhere to mCD22; two Th0 clones and one Th1 clone bound CD22+ BHK transfectants, but not all T cell clones bound CD22+ cells: another Th1 clone and a Th2 clone did not. mCD22+ BHK transfectants were also specifically bound by the B cell-specific mAb, NIM-R6, demonstrating that this mAb is specific for murine CD22. Human cell lines expressing the counter-receptors for human CD22 were also examined for adhesion to the murine CD22 homologue; the epitope responsible for B cell adhesion to CD22 is conserved, whereas the T cell epitope binding to CD22 is not. The cDNA and mAb to murine CD22 will be useful for defining the in vivo function of CD22. 相似文献