editorial

Fouling of heat exchangers is a chronic problem in processing industries. In addition to the appropriate selection of operating conditions and exchanger geometry, there are numerous chemical and mechanical methods to mitigate fouling and to remove deposits from the heat transfer surfaces. However, all methods to reduce fouling require some understanding of the mechanisms of the deposition process and of the structure and adhesion of deposits on the heat transfer surfaces. Almost exactly 50 years ago, D. Q. Kern and his co-author, R. E. Seaton, published a paper attempting to describe the growth of fouling deposits in terms of an unsteady-state heat and mass balance for the heat transfer surface. More or less at the same time, the TEMA fouling resistances were published based on operational and anecdotal evidence of fouling for a range of heat exchanger applications. These two approaches have since formed the basis for most heat transfer fouling models and heat exchanger designs. Increased costs of energy, raw materials, and production downtime have contributed to the growing interest in heat transfer fouling. More recently, environmental legislation has put additional pressure on fouling-related CO₂ emissions and disposal of cleaning chemicals. Despite these efforts, fouling of heat exchangers is still far from been understood in its whole complexity. The present paper documents the 2009 D. Q. Kern Award Lecture in which some selected aspects of fouling research to date have been presented and areas have been identified where significant research and development activities are still required.     

Short communication: Postruminal infusion of conjugated linoleic acids negatively impacts milk synthesis in Holstein cows

In view of the potential of rumen-protected conjugated linoleic acid (CLA) as a means to increase the CLA content of bovine milk, a study was undertaken to evaluate the effect of synthetic CLA on milk production and composition. Four Holstein cows received abomasal infusion of: 1) control, no lipid infusion, 2) 150 g/d of synthetic CLA, 31.7% cis-9, trans-11; 30.4% trans-10, cis-12, 3) 150 g/d of safflower oil, and 4) 150 g/d of tallow. Infusion was carried out for 20 to 22 h/d for 11-d periods in a 4 x 4 Latin square design. The milk fat concentration of cis-9, trans-11 and trans-10, cis-12 isomers of CLA was significantly increased with infusion of CLA. However, CLA infusion had other unexpected effects on milk production and composition. Milk yield dropped significantly during the period of CLA infusion. Furthermore, as well as the typical depression in milk fat reported with trans-10 isomers of CLA, other negative effects specific to CLA infusion were observed including a drop in lactose concentration and yield, a drop in protein yield, and an elevated somatic cell count. The important difference between synthetically produced CLA and CLA produced naturally in the cow is the much higher proportion of trans-10 isomers of CLA in the former. The results of this study suggest that the extent of enrichment possible for trans-10 isomers of CLA, and hence the usefulness of synthetic CLA for this purpose, may be limited because of unacceptable effects on milk yield and composition.     

Review of high level fault modeling approaches for mixed-signal systems

In the modern analogue design, Transistor Level Fault Simulation (TLFS) plays the important part since every fault in the whole circuit has to be simulated at that level. Unfortunately, it is a very CPU intensive task even though it maintains the high accuracy. Therefore, High Level Fault Modeling (HLFM) and High Level Fault Simulation (HLFS) are required in order to alleviate the efforts of simulation. In this paper, different HLFM approaches are reviewed at the device level during last two decades. We clarify their domains of application and evaluate their strengths and current limitations. We also analyze causes of faults and introduce various test approaches.     

Editorial

Editorial Introduction

Editorial     

Characterization of film-coated aerosol canisters using electrochemical impedance spectroscopy

Drug adhesion to the walls of an aerosol canister can be prevented/reduced by coating the canister with a hydrophobic polymer (e.g., a fluoropolymer). In this study, three batches of fluoropolymer-coated canisters were investigated by electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). The EIS technique showed that only one of the batches presented as a monolithic, non-porous film. The other two batches were either partially porous or highly porous. Scanning electron micrographs showed evidence of cracks, within the films, but could not alone establish the porous nature of these defects. For the non-porous and partly porous films it was possible to use the EIS data to determine the approximate film thickness. Estimates of 2-4 µm were obtained for the mean film thickness. These values compared favorably with micrometer estimates obtained following acid dissolution of the aluminum canister. It remains to be seen whether the properties of the films (i.e., the porosity and film thickness, determined by EIS) translate to differences in drug adhesion. Nevertheless, the EIS technique was shown to be a powerful, non-destructive method that lends itself to the rapid analysis of batch-to-batch variation in film-coated canisters.     

Scar formation and ligament healing

OBJECTIVE: To compare the efficacy of IUI husband in natural versus FSH stimulated cycles. DESIGN: Prospective, controlled study. MATERIALS AND METHODS: IUI were performed in 57 infertile couples with natural cycles, and in 16 under FSH and GnRH stimulation (Short protocol). In stimulated patients also hCG and hydrogesteron were given. Indication in both groups was idiopathic infertility. Duration of infertility and the age were comparable. Semen preparation and ovarian monitoring were the same in 2 groups. RESULTS: Three pregnancies in 57 natural IUI cycles (5.3%) and 5 out of 16 cycles in stimulated women (31.2% per cycle-with one triple pregnancy). CONCLUSION: In couples with idiopathic infertility FSH stimulation significantly increases rate of pregnancy and multiple gestation.     

Tools to engineer new technologies into applications

How will consumers, engineers, and businesses benefit from the latest computer technology? Technologists envision graphical, multimedia interfaces to the information highway, but technology like graphical user interfaces, multimedia, and groupware does not appear in applications by magic. Whether the target application is an information system, a consumer product, or a real-time embedded system, developers must expand their engineering environments to incorporate tools for new technologies. To win the race to market, suppliers must pursue various approaches to improve their engineering process. The authors explore these key aspects of development support for new applications: technology-specific tools, reuse, computer-aided software engineering, testing, and integrated development environments