Radiopharmacology of inhaled 133Xe in skeletal sites containing deposits of Gaucher cells

Gaucher's disease is a lysosomal storage disease in which cells of the reticuloendothelial system accumulate the lipid glucocerebroside. It is characterized by slowly progressive visceral and osseous involvement. One of the latter manifestations includes lipid infiltration of bone marrow. We monitored the rate of inhaled 133Xe uptake and wash-out over diseased and normal metaphyseal and epiphyseal areas of the knee. Twenty-two patients (15 adults, 7 children) with various degrees of previously diagnosed Gaucher's disease were positioned supine under a gamma-camera interfaced to a computer system. All patients rebreathed 133Xe gas from a closed system for 10 min followed by 14 min of wash-out. Digitized images of the lung, liver, spleen, bony sites and soft tissue were obtained at 1 min intervals during the wash-in and wash-out phases. Counts for each ROI were normalized per 100 pixels and plotted as a function (time). Maximum uptake was also calculated by relating the counts/ROI/100 pixels to the 10 min integrated lung count during equilibrium (the administered "dose"). There was essentially no 133Xe uptake in liver and spleen involved with Gaucher's disease. Monophasic uptake and biphasic wash-out curves were observed in the limited investigative population. Skeletal Gaucher deposits released the 133Xe at a greater rate relative to soft tissue.     

Effects of hypothalamic temperature changes on the sweat rate in Macaca mulatta

The concept of cardiac reconditioning centers for the prevention and rehabilitation of coronary patients has been tremendously successful in Germany over the past 20 years. At least 40 such centers are located throughout the country. Physicians, nurses, and physical therapists work closely together in the various facets of the rehabilitation process. The financial backing for these facilities is primarily through governmental and regional insurance companies, whose officials are apparently convinced that in the long run supporting preventive measures is financially sound. Objective data supporting their convictions come from studies such as that of Brusis, who showed that such as that of 1,500 employees was diminished by nearly 70 percent during a two-year period after cardiac reconditioning, as compared to a similar time period before the rehabilitation experience. Subjective benefits, which are extremely difficult to quantitate in meaningful terms, were nonetheless expressed by nearly all the patients with whom I conversed. Perhaps they have experienced the same feelings that Mark Twain did when he observed that "all frets and worries and chafings sank to sleep in the presence of the benignant serenity of the Alps; the Great Spirit of the Mountains breathed his own peace upon their hurt minds and sore hearts and healed them."     

A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development

Effects of etoposide (VP-16) and cytosine arabinoside (Ara-C) on the cell cycle of HL-60 and THP-1 cells were studied by flow cytometry using the bromodeoxyuridine (BrdU)/DNA assay technique to investigate the efficacy of VP-16 for monocytic leukemia cells. VP-16 inhibited the proliferation of THP-1 cells more strongly than that of HL-60 cells at any concentrations used at 24 and 48 hr. VP-16 arrested HL-60 and THP-1 cells in the G2/M phase and reduced them in the G0/G1 and early S phase at higher concentrations. There was no significant difference in the percentage of G2/M phase cells at the same concentration between both cells. However, reduction in the G0/G1 and early S phase cells was more marked in THP-1 than HL-60 cells significantly. On the other hand, Ara-C perturbed the cell cycle of HL-60 cells more than that of THP-1 cells at 24 and 48 hr. These results suggest that the effects of VP-16 on the cell cycle may be more intense in THP-1 than HL-60 cells, and support the efficacy of VP-16 for treating monocytic leukemia in vivo.     

The eye of Eila Hopper Ross

In 1936, when Eila Hopper Ross (nee Hopper) was putting the final stroke of paint on her six-foot oil canvas of a life model at the Ontario College of Art, she had not dreamed that in the year to follow she would embark upon a life's career of anatomical study and attention to intricate detail in her own work as a medical illustrator. Though she had early aspirations herself of going into medicine--having been raised in a medical environment with her father, Dr. David Alexander Hopper, regularly receiving pharmaceutical literature with impressive illustrations--Hopper Ross was not aware of medical illustration as a profession. It was Maria Wishart, then director of the Medical Art Service Unit at the University of Toronto, who saw Hopper Ross' final exhibition at the Ontario College of Art and recommended she consider a career in medical art. As a result, Hopper Ross studied for two years (1937-1939) in the Department of Art as Applied to Medicine at Johns Hopkins University in Baltimore, Maryland under the direction of Professor Max Br?del.     

Contextual neglect, self-evaluation, and the frog-pond effect.

Social comparisons entail not only information about one’s standing in a social group (intragroup or local comparison) but also information about the standing of the group in comparison to other groups (intergroup or general comparison). In Studies 1–3, the authors explored the relative impact of intergroup and intragroup comparisons on self-evaluations and affect. While intragroup comparison feedback consistently impacted self-evaluations and affect, intergroup comparison information exerted a significant impact only when intragroup comparison information was unavailable. The authors refer to this general tendency as contextual neglect. Studies 4 and 5 showed that contextual neglect is due primarily to the fact that low-level, local comparison information displaces or supersedes the effect of higher level, general comparison data and that people clearly recognize the superior diagnosticity of higher level comparisons while continuing to rely on small, haphazard sample data to evaluate their ability. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Photoelectric properties of MISM phthalocyanine structure

Langmuir-Blodgett films have been prepared from copper tetra-4-t-butylphthalocyanine. A voltage dependence of capacitance can be attributed to the presence of a Schottky depletion layer. The barrier potential was determined as l·4eV, and the carrier concentration about 10²⁴m^?3