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RM Summers J Andrasko-Bourgeois IM Feuerstein SC Hill EC Jones MK Busse B Wise KE Bove BA Rishforth E Tucker TL Spray JM Hoeg 《Canadian Metallurgical Quarterly》1998,98(6):509-518
Hepatitis C chronically infects approximately 1.5% of Americans and is the most common clinical problem facing hepatologists. Since the virus was initially described in 1989, development of an effective therapy has been challenging. Although several different therapeutic agents have been used, no therapy has been shown to reliably eradicate the virus. Interferon-alpha, a cytokine with immunostimulatory and anti-viral properties, has become the therapy of choice for patients with chronic hepatitis C infection. Trials assessing the efficacy of interferon-alpha have characterized host and viral factors predictive of responses to treatment. A thorough understanding of these predictive factors is requisite to providing cost-effective therapeutic decisions for the patient with chronic hepatitis C infection. 相似文献
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From the corrosion fatigue test under intermit-tent wetting condition for offshore structural steelof A537 cl.l and data analysis,some results associ-ated with the role of pits in fatigue process havebeen discussed. 相似文献
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The transient current behaviour for Iron in 3.5%NaCl and 3.5%NaCl +1%NaNO2 solutions during corrosion fatigue (CF) process has been investigated at different given strain amplitudes and strain rates. The results show that elastic strain has little contribution to material dissolution. The elastic tension strain results in the decrease in the transient current, while the elastic compression strain increases the transient current. Compared to the elastic deformation, plastic deformation affects material dissolution evidently For iron in 3.5%NaCl solution, the strain amplitude plays a dominant role in the dissolution process accelerated by the plastic strain, while in 3.5%NaCl+1%NaNO2 solution, both the strain amplitude and strain rate play an important role in this process. In this paper, the effect of the elastic deformation on the material dissolution and the relation between the tension and compression current peak values under the plastic cycle deformation are discussed 相似文献
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WC Miller KE Eggert JP Wallace AK Lindeman C Jastremski 《Canadian Metallurgical Quarterly》1993,14(7):401-405
There is little evidence concerning the effectiveness of self-help materials for weight control. The purpose of this research was to evaluate a self-help weight-loss program. Obese (body fat > or = 25.0%, range = 25.0-48.6%, mean +/- SEM = 36.5 +/- 1.3%) men (n = 14) and women (n = 21) were given a workbook detailing a behavior modification approach to weight loss that emphasizes self-monitoring of diet and exercise behaviors, and then sent home for 6 months to learn how to lose weight on their own. A group of 9 controls (CONT) who did not get a workbook were used for comparison. ANOVA showed that the experimental group (EXP) lost 8.1 +/- 0.9 (mean +/- SEM) kg body weight, 6.4 +/- 0.8 kg fat, and 3.9 +/- 0.6% body fat; all significant over time (p < 0.001) and different from the CONT (p < 0.0001) who showed no change in these variables. The EXP also reduced their fat intake (% of joules) from 36.1 +/- 1.0% to 27.9 +/- 1.3% (p < 0.0001), increased their carbohydrate intake from 45.7 +/- 1.2% to 50.0 +/- 1.7% (p < 0.007) and their protein intake from 16.3 +/- 0.05% to 20.7 +/- 0.7% (0 < 0.03), all of which were significantly different (p < 0.03) than the CONT who did not change. Dietary fiber increased in the EXP from 19.8 +/- 1.4 to 27.3 +/- 2.2 g/d (p < 0.001) even with a significant reduction in energy intake (11.3 +/- 0.6 vs. 8.9 +/- 0.5 Mj/d; p < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献