Flow characteristics around a row of circular and wavy cylinders

The near-wake and flow interference around a row of five circular cylinders, staggered wavy cylinders and nonstaggered wavy cylinders are investigated experimentally by using PIV and LIF techniques. The effects and characteristics of employing wavy cylinders instead of circular cylinders are discussed. The cylinders were arranged atT/d=1.5 withRe ranging from 125 to 40000. Results showed the staggered wavy cylinders give rise to a more stable flow pattern with less fluctuation and longer wake vortex closure length.     

The mutK gene of Vibrio cholerae: a new gene involved in DNA mismatch repair

A new gene, mutK, of Vibrio cholerae, encoding a 19-kDa protein which is involved in repairing mismatches in DNA via a presumably methyl-independent pathway, has been identified. The product of the mutK gene cloned in either high- or low-copy-number vectors can reduce the spontaneous mutation frequency of Escherichia coli mutS, mutL, mutU, and dam mutants. The spontaneous mutation frequency of a chromosomal mutK knockout mutant was almost identical to that of wild-type V. cholerae cells, indicating that when the methyl-directed mismatch repair is blocked, the repair potential of MutK becomes apparent. The complete nucleotide sequence of the mutK gene has been determined, and the deduced amino acid sequence showed three open reading frames (ORFs), of which the ORF3 represents the mutK gene product. The mutK gene product has no significant homology with any of the proteins deposited in the EMBL data bank. ORF2, located upstream of mutK, encodes a 14-kDa protein which has more than 70% homology with a hypothetical protein found only downstream of the E. coli vsr gene. ORF1, located farther upstream of mutK, has more than 80% homology with a major cold shock protein found in several bacteria. Downstream of mutK, a partial ORF having 60% homology with an RNA methyltransferase has been identified. The mutK gene has recently been positioned in the ordered cloned DNA map of the genome of the V. cholerae strain from which the gene was isolated (10).     

Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors

The efficacy of therapeutics for brain tumors is seriously hampered by multiple barriers to drug delivery, including severe destabilizing effects in the blood circulation, the blood–brain barrier/blood–brain tumor barrier (BBB/BBTB), and limited tumor uptake. Here, a sequential targeting in crosslinking (STICK) nanodelivery strategy is presented to circumvent these important physiological barriers to improve drug delivery to brain tumors. STICK nanoparticles (STICK-NPs) can sequentially target BBB/BBTB and brain tumor cells with surface maltobionic acid (MA) and 4-carboxyphenylboronic acid (CBA), respectively, and simultaneously enhance nanoparticle stability with pH-responsive crosslinkages formed by MA and CBA in situ. STICK-NPs exhibit prolonged circulation time (17-fold higher area under curve) than the free agent, allowing increased opportunities to transpass the BBB/BBTB via glucose-transporter-mediated transcytosis by MA. The tumor acidic environment then triggers the transformation of the STICK-NPs into smaller nanoparticles and reveals a secondary CBA targeting moiety for deep tumor penetration and enhanced uptake in tumor cells. STICK-NPs significantly inhibit tumor growth and prolong the survival time with limited toxicity in mice with aggressive and chemoresistant diffuse intrinsic pontine glioma. This formulation tackles multiple physiological barriers on-demand with a simple and smart STICK design. Therefore, these features allow STICK-NPs to unleash the potential of brain tumor therapeutics to improve their treatment efficacy.     

On consistent reading of entire databases

Many applications need to read an entire database in a consistent way. This global-reading of an entire database formulated as a global-read transaction (GRT) is not a trivial issue since it will cause a high degree of interference to other concurrent transactions. Conventional concurrency control protocols are obviously inadequate in handling the long-lived GRT. Previous studies proposed additional tests, namely, the color test and the shade test, to handle conflicts between the GRT and update transactions. However, we discovered that both algorithms can bring about nonserializable schedules of transactions. We propose an enhanced algorithm directly built on the two algorithms to guarantee the serializability of transactions.     

Stabilization of discrete-time Markovian jump linear systems via time-delayed controllers

This paper is concerned with the stabilization problem for a class of discrete-time Markovian jump linear systems with time-delays both in the system state and in the mode signal. The delay in the system state may be time-varying. The delay in the mode signal is manifested as a constant mismatch of the modes between the controller and the system. We first show that the resulting closed-loop system is a time-varying delayed Markovian jump linear system with extended state space. Then a sufficient condition is proposed for the design of a controller such that the closed-loop system is stochastically stable. Finally, numerical simulation is used to illustrate the developed theory.     

A buffered-bandwidth approach for supporting real-time video streaming over cellular networks

In this paper, we study the admission and bandwidth allocation problems in real-time video streaming in a cellular network. Admission control in a cellular network is a complex issue due to the mobility of the clients, and the additional workload imposed by incoming clients could exceed the network capacity of a cell and seriously degrade the quality of services provided to the resident clients. To minimize the number of forced terminations of real-time video playback, we incorporate the notion of buffered bandwidth in the admission test for handoff client. Using this approach, we can balance the video workload among adjacent cells to minimize the impact of overloading as the result of handoff operations. We also examine techniques to maintain fairness in services especially under overload situations even though the requested videos from various types of clients could generate very different workload. Simulation experiments confirm the effectiveness of our approach compared to widely used schemes.     

Micro‐Layer and Lattice Structure Effects on Impedance of Titanium Oxide Phthalocyanine

In this study, the authors employ synchrotron techniques to characterize multi‐scale microstructure in elucidating how the modified crystal lattices at angstrom level and molecular stacking at micrometer scale of titanium oxide phthalocyanine (TiOPc) thin film tuning the impedance. The a and c lattice lengths of the TiOPc reveal a positive correlation with the impedance because of the π‐π stacking distances of TiOPc molecules arrangements. Our results suggest a promising dip coating method to tailor the charge storage capability of TiOPc through controlling the crystal lattice sizes of TiOPc.

     

Forensic implications and medical-legal dilemmas of maternal versus fetal rights

The purpose of this paper is to review the issue of fetal rights from primarily a legal perspective, with consideration of morals and professional ethics. The practice of medicine is fraught with numerous bioethical dilemmas. These dilemmas often leave the physician wondering if he has made the correct decision. A physician's morals and professional ethics may influence his or her decision in resolving bioethical dilemmas. The case example is a 34-year-old female with a 41-week intra-uterine pregnancy. The mother was refusing induction of labor. Without the labor induction, the fetus may die. Despite this risk, the mother desired to pursue a vaginal delivery. The AMA's ethics state that a competent, pregnant mother's wishes should prevail and the court should not be involved unless there are unusual circumstances. The mother in the case example was competent and informed consent was provided. Case law does not specifically address the dilemma of the case example. However, there is case law regarding court-ordered cesarean sections which reveals different opinions. The difference in court opinion encompasses the relative degree of weight given to the fetus's right to be born healthy and alive versus the mother's privacy rights. Some courts describe this "balancing test," whereas others state that the mother's privacy rights prevail unless there are exceptional circumstances, which will be extremely rare. The fetus has acquired rights in other areas of the law; for example, abolishment of the intra-family immunity doctrine and the definition of murder in most states. In considering the legal arena of fetal versus maternal rights, a decision tree is presented to assist physicians in assessing cases of a pregnant mother refusing medical treatment. There is no precise demarcation in assessing fetal and maternal rights. The greater the degree of fetal viability, the greater degree of fetal rights. Consideration must also be given to the relative degree of invasiveness to the mother for the proposed procedure; the more invasive, the greater degree of maternal rights. Each case must be evaluated on an individual basis and the decision tree can assist a clinician with this process.     

Improvement of CT-based treatment-planning models of abdominal targets using static exhale imaging

PURPOSE: CT-based models of the patient that do not account for the motion of ventilation may not accurately predict the shape and position of critical abdominal structures. Respiratory gating technology for imaging and treatment is not yet widely available. The purpose of the current study is to explore an intermediate step to improve the veracity of the patient model and reduce the treated volume by acquiring the CT data with the patients holding their breath at normal exhale. METHODS AND MATERIALS: The ventilatory time courses of diaphragm movement for 15 patients (with no special breathing instructions) were measured using digitized movies from the fluoroscope during simulation. A subsequent clinical protocol was developed for treatment based on exhale CT models. CT scans (typically 3.5-mm slice thickness) were acquired at normal exhale using a spiral scanner. The scan volume was divided into two to three segments, to allow the patient to breathe in between. Margins were placed about intrahepatic target volumes based on the ventilatory excursion inferior to the target, and on only the reproducibility of exhale position superior to the target. RESULTS: The average patient's diaphragm remained within 25% of the range of ventilatory excursion from the average exhale position for 42% of the typical breathing cycle, and within 25% of the range from the average inhale position for 15% of the cycle. The reproducibility of exhale position over multiple breathing cycles was 0.9 mm (2sigma), as opposed to 2.6 mm for inhale. Combining the variation of exhale position and the uncertainty in diaphragm position from CT slices led to typical margins of 10 mm superior to the target, and 19 mm inferior to the target, compared to margins of 19 mm in both directions under our prior protocol of margins based on free-breathing CT studies. For a typical intrahepatic target, these smaller volumes resulted in a 3.6% reduction in Veff for the liver. Analysis of portal films shows proper target coverage for patients treated based on exhale modeled plans. CONCLUSIONS: Modeling abdominal treatments at exhale, while not realizing all the gains of gated treatments, provides an immediate reduction in the volume of normal tissue treated, and improved reliability of patient data for NTCP modeling, when compared to current "free breathing" CT models of patients.