Long-term prognosis for women with chronic pelvic pain without laparoscopically demonstrable cause

With the object of assessing the long-term prognosis and the frequencies of recurrence and remission in women chronic low abdominal pain without laparoscopically visible cause, questionnaire were sent in 1985 and 1991 to 55 women who had been submitted to laparoscopy in 1982-1984 for this reason. These women had been told that there was no demonstrable explanation of the pain experienced and were then discharged. 65% and 55% respectively had experienced and unfavourable course with considerable and continued symptoms. Only 22% stated in both investigations that they had experienced a favourable course and that they were, by and large, free from pain. 36% changed from an unfavourable to a favourable course or the reverse. The assessment made by the women was confirmed by a series of subordinate questions and this demonstrated a marked difference between the favourable and unfavourable courses of the condition. It is concluded that laparoscopy with exclusion of significant pathology is not, in itself, satisfactory as treatment of this patient group and that no improvement occurs in the course of time. The condition varies greatly with many recurrences and remissions and, for this reason, uncontrolled reports of the therapeutic effects are of no significance. When compared with the literature, it is suggested that this patient group should be referred early in the course of the condition to a therapist with specialist psychological/sexological insight and/or to a physiotherapist with interest in this patient group.     

Performance of Alamouti transmit diversity over time-varying Rayleigh-fading channels

We analyze the impact of a time-varying Rayleigh-fading channel on the performance of an Alamouti transmit-diversity scheme. We propose several optimal and suboptimal detection strategies for mitigating the effects of a time-varying channel, and derive expressions for their bit-error probability as a function of the channel correlation coefficient /spl rho/. We find that the maximum-likelihood detector that optimally compensates for the time-varying channel is very tolerant to time-varying fading, attaining full diversity order even for the extreme case of /spl rho/=0. In contrast, although lower in complexity, the suboptimal schemes suffer a diversity penalty and are thus suitable only for slowly fading channels.     

Re-examination of residual arousal as an explanation of aftereffects: Frustration tolerance versus response speed.

Three experiments, with 98 undergraduates, investigated the effects of increasing task difficulty and noise intensity on postnoise persistence on the Feather tolerance for frustration puzzles. In Exp I, greater persistence occurred both after exposure to moderate noise levels (55 db [A]) and an easy perceptual-motor task and after high noise levels (90 db [A]) and a more difficult task. The same pattern of persistence was obtained in Exp II, with more attempts to solve the Feather puzzles occurring after moderate noise and an easy cognitive task and after loud noise and a more difficult cognitive task. In Exp III, a modified Feather task was presented with instructions to determine solvability. A similar U-shaped relationship was obtained, with longer correct response times to unsolvable puzzles following low noise and high noise. Such aftereffect patterns are more easily explained as the result of residual arousal than of frustration tolerance. (21 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Book review

Published in 1989, 585 pages, $180; Available from the American Institute of Chemical Engineers, 345 East 47th St., Publication Sales Department, New York, NY 10017.     

Phenomena-based thermal-hydraulic modeling requirements for systems analysis of a Modular High Temperature Gas-Cooled Reactor

The Modular High Temperature Gas-Cooled Reactor (MHTGR) is a candidate design for new production and commercial power nuclear reactors. The MHTGR has inherent safety features including: (1) passive shutdown and decay heat removal, (2) reduced requirements for operator intervention, thereby reducing sensitivity to operator error, and (3) long time intervals for corrective action. In support of the Department of Energy's (DOE) initial development of the design, the authors have completed an evaluation of the thermal-hydraulic phenomena that will dominate the plant response during representative normal, off-normal and accident conditions. Phenomena having significance to the plant behavior have been identified, and ranked with respect to their relative importance in satisfying operational, investment and/or safety criteria. The resulting information provides the basis for evaluating the applicability of existing computer codes, and defines the requirements for the development of new codes, for thermal-hydraulic systems analysis. The phenomena-based requirements also support the quality assurance related verification and validation of these codes. This paper briefly describes the methodology employed, and gives illustrative examples of the resulting requirements. References are cited for reports that document the full body of requirements and provide additional information for the methodology.     

Personal reminiscences of a psychologist married couple on changing perspectives in 20 years of professional psychology.

The authors describe their perspectives as a psychologist married couple and discuss some of the major trends that have affected their work in the last years, including the women's movement and new developments in the field of psychology. They note both positive and negative changes from the last 2 decades. Whereas there are many more new and exciting opportunities for psychologists today, there are also more pressures, more stringent training and credentialing requirements, more competition, and less mobility. Also discussed are some advantages to being married to another psychologist, including understanding each other's roles, combining social and professional lives, and expanding professional networks. They look to the future of psychology with optimism and hope that by examining and changing some of the restrictions on psychologists today, the field of professional psychology can be made more rewarding for future psychologists. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia

In this study we have examined (1) the integrated function of the mitochondrial respiratory chain by polarographic measurements and (2) the activities of the respiratory chain complexes I, II-III, and IV as well as the ATP synthase (complex V) in free mitochondria and synaptosomes isolated from gerbil brain, after a 30-min period of graded cerebral ischaemia. These data have been correlated with cerebral blood flow (CBF) values as measured by the hydrogen clearance technique. Integrated functioning of the mitochondrial respiratory chain, using both NAD-linked and FAD-linked substrates, was initially affected at CBF values of approximately 35 ml 100 g-1 min-1, and declined further as the CBF was reduced. The individual mitochondrial respiratory chain complexes, however, showed differences in sensitivity to graded cerebral ischaemia. Complex I activities decreased sharply at blood flows below approximately 30 ml 100 g-1 min-1 (mitochondria and synaptosomes) and complex II-III activities decreased at blood flows below 20 ml 100 g-1 min-1 (mitochondria) and 35-30 ml 100 g-1 min-1 (synaptosomes). Activities declined further as CBF was reduced below these levels. Complex V activity was significantly affected only when the blood flow was reduced below 15-10 ml 100 g-1 min-1 (mitochondria and synaptosomes). In contrast, complex IV activity was unaffected by graded cerebral ischaemia, even at very low CBF levels.     

Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2

Recent studies have shown that long-term in vivo exposure of dogs to neutral sulfur(IV)/sulfite aerosols induces mild inflammatory reactions, whereas the combination of neutral sulfite with acidic sulfur(VI)/sulfate aerosols evokes less pronounced effects. To understand underlying mechanisms, we studied in vitro the role of lipid mediators in the responses of alveolar macrophages (AMs) to sulfur-related compounds under neutral (pH 7) or moderate acidic (pH 6) conditions. Canine AMs incubated with sulfite at pH 7 released threefold higher amounts of platelet-activating factor than control (P < 0.005). Generation of arachidonic acid, leukotriene B4, 5-hydroxy-eicosatetraenoic acid, prostaglandin E2, thromboxane B2 and 12-hydroxyheptadecatrienoic acid increased twofold (P < 0.0005). However, these metabolites remained unchanged following incubation of AMs with sulfite at pH 6 or with sulfate at pH 7 or pH 6. Mediator release by sulfite-treated AMs at pH 7 stimulated respiratory burst activity of neutrophils. Inhibition of MAPK pathway by PD 98059, of cytosolic (cPLA2) and secretory phospholipases A2 by AACOCF3 and thioetheramide-PC, respectively, reduced sulfite-induced eicosanoid formation in AMs. Sulfite activated cPLA2 activity twofold at pH 7. This mechanism of sulfite-stimulated responses in phospholipid metabolism predicts that chronic exposure to sulfur(IV)/sulfite is associated with a considerable health risk.     

Does Privacy Have a Future after 9/11?

A few years ago, Sun Microsystems CEO Scott McNealy created uproar by declaring: ‘You have zero privacy. Get over it.’ ( Sprenger, 1999 ) The question, at least for Americans, is did the 11 September terrorist attacks – and the response to them – prove him right? Is privacy really dead?