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71.
Effects were studied of vincamin and tanakan in 68 patients with stage I, II and III discirculatory encephalopathy (as per WHO classification 1981). In 52% of the patients atherosclerosis of brain vessels was associated with arterial hypertension (group I), in 48 per cent venous discirculatory encephalopathy was diagnosable against the background of arterial hypertension (group IIA-20%) and arterial hypotension (group IIB-26%). Both tanakan and vincamin were found to be effective in group I patients; however, in stage III condition their effectiveness was no better than 42 and 15% respectively, which fact might be due to organic changes in the vascular wall. Tanakan appeared to be more beneficial in group II patients since venous dystonia is considered to be the main pathogenetic link in this context, and tanakan is known to improve the venous outflow from the cranial cavity. Almost in one-third of group IIB patients vincamin worsened general health status, especially so in stage III discirculatory encephalopathy, which fact may be related to peculiar effect of the drug on the arterial link of brain blood supply. 相似文献
72.
Eric Gabriel 《International Journal of Project Management》1985,3(4):231-232
The role of the project manager has traditionally concentrated upon the execution of a project, from conception to completion. The commissioning and operation have been a secondary priority, for good reasons which are discussed in this paper. Nowhere has this been more true than in building construction, despite the fact that a building is a place where there is maximum interaction with people of all types. Some 10% of people worldwide are disabled, which prevents them from using buildings and facilities designed for able-bodied people. All this is changing rapidly. No longer should buildings be designed to be accessible only to the majority, nor should special arrangements be provided as an ‘extra’ for disabled people. Design philosophy is being impelled to provide for all building users. Great impetus was provided by the 1981 International Year of Disabled Persons, designated by the United Nations. In the UK, The Prince of Wales' Advisory Group on Disability and the Access Committee for England are influential and active organizations that are exerting a powerful influence for change. New building regulations are introducing a statutory imperative. The attention of project managers is drawn to what is happening in this area, and it is suggested that in their unique position they can influence the bridging of the gap between designers and building operators, to ensure that buildings can be used by all, and that nothing is overlooked at any stage. Legislation alone cannot solve the problem, and a change in attitude is necessary. 相似文献
73.
74.
KL Miller 《Canadian Metallurgical Quarterly》1994,6(4):785-803
Endocrine disorders in critically ill infants and children can be the manifestation of an existing but previously unrecognized condition, or hormonal derangements precipitated by deleterious effects on endocrine function of a critical illness or its prescribed therapy. To achieve successful resolution of these crises, a general understanding of various endocrine dysfunctions, clinical symptomatology, diagnosis, and medical and nursing management is essential. 相似文献
75.
76.
P. B. Malafaya A. J. Pedro A. Peterbauer C. Gabriel H. Redl R. L. Reis 《Journal of materials science. Materials in medicine》2006,17(7):675-675
In the XML file of the original article, H. Redl’s affiliation is incorrect. It is listed correctly in both the paper and
PDF versions of the article, and can be found below:
The online version of the original article can be found at 相似文献
77.
Protein phosphorylation plays a central role in many biological and biomedical phenomena. In this review, while a brief overview of the occurrence and function of protein phosphorylation is given, the primary focus is on studies related to the detection and analysis of phosphorylation both in vivo and in vitro. We focus on phosphorylation of serine, threonine and tyrosine, the most commonly phosphorylated amino acids in eukaryotes. Technologies such as radiolabelling, antibody recognition, chromatographic methods (HPLC, TLC), electrophoresis, Edman sequencing and mass spectrometry are reviewed. We consider the speed, simplicity and sensitivity of tools for detection and identification of protein phosphorylation, as well as quantitation and site characterisation. The limitations of currently available methods are summarised. 相似文献
78.
We describe methods for the production of fluorescence in situ hybridization (FISH) probes and the utilization of these probes for the detection of complementary DNA sequences with accuracy and sensitivity for application in both basic research and clinical diagnosis. Due to the frequent use of FISH in many laboratories, it is important to apply the most convenient and reproducible approach. This review describes some of the most recent techniques, and includes versatile, effective and simple methods of probe production and fluorescence in situ hybridization. We also describe methods for the production of region-specific and chromosome-specific DNA probes and hybridization techniques for the visualization of these probes. 相似文献
79.
KL Nicholson M Munson RB Miller TJ Filip R Fairman FM Hughson 《Canadian Metallurgical Quarterly》1998,5(9):793-802
The fusion of intracellular transport vesicles with their target membranes requires the assembly of SNARE proteins anchored in the apposed membranes. Here we use recombinant cytoplasmic domains of the yeast SNAREs involved in Golgi to plasma membrane trafficking to examine this assembly process in vitro. Binary complexes form between the target membrane SNAREs Sso1p and Sec9p; these binary complexes can subsequently bind to the vesicle SNARE Snc2p to form ternary complexes. Binary and ternary complex assembly are accompanied by large increases in alpha-helical structure, indicating that folding and complex formation are linked. Surprisingly, we find that binary complex formation is extremely slow, with a second-order rate constant of approximately 3 M(-1) s(-1). An N-terminal regulatory domain of Sso1p accounts for slow assembly, since in its absence complexes assemble 2,000-fold more rapidly. Once binary complexes form, ternary complex formation is rapid and is not affected by the presence of the regulatory domain. Our results imply that proteins that accelerate SNARE assembly in vivo act by relieving inhibition by this regulatory domain. 相似文献
80.
KL Hanson 《Canadian Metallurgical Quarterly》1998,35(3):294-302
The gutless hydrothermal tubeworm Riftia pachyptila Jones relies mainly on its chemoautotrophic bacterial symbionts to supply nutrients in the form of secreted organic compounds resulting from fixation and incorporation of CO2. In this study, symbionts were purified, tested for viability, and incubated in the presence of labeled CO2. We demonstrated that purified symbionts can be used as a viable alternative to experiments with bacterial cultures. Several organic acids, sugars, and amino acids were labeled, but their fraction of the total label stayed generally constant during the incubation times used. However, increasing fractions of succinate and, to a lesser degree, glutamate were excreted into the incubation medium, indicating that these are probably the main carbon-containing compounds transferred from the symbionts to the host. Glutamate could also account for the transport of nitrogen from the symbionts to the host. 相似文献